The histone variant macroH2A1.1 is recruited to DSBs through a mechanism involving PARP1
Open accessAbstract
The repair of DNA double‐strand breaks (DSBs) requires remodeling of the local chromatin architecture to allow the repair machinery to access sites of damage. Here, we report that the histone variant macroH2A1.1 is recruited to DSBs. Cells lacking macroH2A1 have defective recruitment of 53BP1, defective activation of chk2 kinase and increased radiosensitivity. Importantly, macroH2A1.1 is not incorporated into nucleosomes at DSBs, but instead associates with the chromatin through a mechanism which requires PARP1 activity. These results reveal an unusual mechanism involving a direct association of macroH2A1.1 with PARylated chromatin which is critical for retaining 53BP1 at sites of damage.
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- Authors
- Xu, C., Xu, Y., Gursoy-Yuzugullu, O., & Price, B. D.
- Affiliations
- Harvard University (US)
- Corresponding author
- Xu, Chang
- Price, Brendan D.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2012-09-29
- Volume
- 586
- Issue
- 21
- Pages
- 3920-3925
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- PMC
- PMC3491562
- OpenAlex
- W2130300210
- Cited by
- 71
- References
- 26
- Citations by year
- 2026: 2 · 2024: 5 · 2023: 2 · 2022: 5 · 2021: 7 · 2020: 6 · 2019: 8 · 2018: 4 · 2017: 8 · 2016: 6 · 2015: 6 · 2014: 7 · 2013: 4 · 2012: 1
- FWCI
- 2.31
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (R01CA064585, R01CA093602, CA64585, CA93602)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
- Keywords
- macroH2A1.1, histone variants, DNA double-strand breaks, PARP1, poly(ADP-ribosyl)ation, 53BP1, radiosensitivity, chromatin remodeling, DNA repair
- MeSH terms
- Poly (ADP-Ribose) Polymerase-1, Tumor Suppressor p53-Binding Protein 1, Chromatin, DNA Repair, Histones, Humans, Nucleosomes, Plasmids, Poly(ADP-ribose) Polymerases, Radiation Tolerance, Radiation, Ionizing, Transfection, Signal Transduction, Protein Serine-Threonine Kinases, Protein Transport, Chromatin Assembly and Disassembly, Cell Line, Tumor, Intracellular Signaling Peptides and Proteins, DNA Breaks, Double-Stranded, Checkpoint Kinase 2
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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