Caspase 8 inhibits programmed necrosis by processing CYLD

O’Donnell, Marie Anne, Perez-Jimenez, Eva, Oberst, Andrew, Ng, Aylwin, Massoumi, Ramin, Xavier, Ramnik, Green, Douglas R., Ting, Adrian T.·2011·Nature Cell Biology

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  94. BindingDB Entry 50020902: Scaffold hopping derived novel benzoxazepinone receptor-interacting protein kinase 1 (RIP1) inhibitors as anti-necroptosis agents: Anti-inflammatory effect in systemic inflammatory response syndrome (SIRS) and epilepsy.
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  95. BindingDB Entry 50008478: Small-Molecule Inhibitors of Necroptosis: Current Status and Perspectives.
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