The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
LncRNA NBR2 engages a metabolic checkpoint by regulating AMPK under energy stress
Open accessAbstract
Long non-coding RNAs (lncRNAs) have emerged as critical regulators in various cellular processes. However, the potential involvement of lncRNAs in kinase signalling remains largely unknown. AMP-activated protein kinase (AMPK) acts as a critical sensor of cellular energy status. Here we show that the lncRNA NBR2 (neighbour of BRCA1 gene 2) is induced by the LKB1–AMPK pathway under energy stress. On energy stress, NBR2 in turn interacts with AMPK and promotes AMPK kinase activity, thus forming a feed-forward loop to potentiate AMPK activation during energy stress. Depletion of NBR2 attenuates energy-stress-induced AMPK activation, resulting in unchecked cell cycling, altered apoptosis/autophagy response, and increased tumour development in vivo. NBR2 is downregulated and its low expression correlates with poor clinical outcomes in some human cancers. Together, the results of our study uncover a mechanism coupling lncRNAs with metabolic stress response, and provides a broad framework to understand further the regulation of kinase signalling by lncRNAs.
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Cites
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AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint
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Self-citationPanwar, V., Singh, A., Bhatt, M., Tonk, R. K., Azizov, S., Raza, A. S., Sengupta, S., Kumar, D., & Garg, M. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01608-z · Cited by 967
A Peptide Encoded by a Putative lncRNA HOXB-AS3 Suppresses Colon Cancer Growth
Huang, J.-Z., Chen, M., Chen, D., Gao, X.-C., Zhu, S., Huang, H., Hu, M., Zhu, H., & Yan, G.-R. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.09.015 · Cited by 709
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Zhang, Y., Swanda, R. V., Nie, L., Liu, X., Wang, C., Lee, H., Lei, G., Mao, C., Koppula, P., Cheng, W., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-21841-w · Cited by 698
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Metadata
- Authors
- Liu, X., Xiao, Z.-D., Han, L., Zhang, J., Lee, S.-W., Wang, W., Lee, H., Zhuang, L., Chen, J., Lin, H.-K., Wang, J., Liang, H., & Gan, B.
- Venue
- Nature Cell Biology
- Published
- 2016-03-21
- Volume
- 18
- Issue
- 4
- Pages
- 431-442
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- OpenAlex
- W2306562666
- Cited by
- 288
- References
- 13
- FWCI
- 13.71
- Type
- journal article
- Language
- en
- Open access
- green
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- Liu, X., Xiao, Z.-D., Han, L., Zhang, J., Lee, S.-W., Wang, W., Lee, H., Zhuang, L., Chen, J., Lin, H.-K., Wang, J., Liang, H., & Gan, B. (2016). LncRNA NBR2 engages a metabolic checkpoint by regulating AMPK under energy stress. Nature Cell Biology. https://doi.org/10.1038/ncb3328
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