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Long non-coding RNA PAARH promotes hepatocellular carcinoma progression and angiogenesis via upregulating HOTTIP and activating HIF-1α/VEGF signaling

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ETV4 overexpression promotes progression of non–small cell lung cancer by upregulating PXN and MMP1 transcriptionally

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Circulating LncRNAs Serve as Diagnostic Markers for Hepatocellular Carcinoma

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The circular RNA circZFR phosphorylates Rb promoting cervical cancer progression by regulating the SSBP1/CDK2/cyclin E1 complex

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Alternative Splicing in Hepatocellular Carcinoma

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Long non‐coding RNA H19 suppresses retinoblastoma progression via counteracting miR‐17‐92 cluster

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Splicing factors: Insights into their regulatory network in alternative splicing in cancer

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The ligation between ERMAP, galectin-9 and dectin-2 promotes Kupffer cell phagocytosis and antitumor immunity

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LncRNA SBF2-AS1 affects the radiosensitivity of non-small cell lung cancer via modulating microRNA-302a/MBNL3 axis

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Astragaloside IV inhibits cell migration and viability of hepatocellular carcinoma cells via suppressing long noncoding RNA ATB

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LncRNA CDKN2B-AS1 stabilized by IGF2BP3 drives the malignancy of renal clear cell carcinoma through epigenetically activating NUF2 transcription

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NEAT1 paraspeckle promotes human hepatocellular carcinoma progression by strengthening IL-6/STAT3 signaling

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SF3B4 is regulated by microRNA-133b and promotes cell proliferation and metastasis in hepatocellular carcinoma

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Dysregulated Long Non-coding RNAs in Parkinson’s Disease Contribute to the Apoptosis of Human Neuroblastoma Cells

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Hepatitis B Virus–Upregulated LNC‐HUR1 Promotes Cell Proliferation and Tumorigenesis by Blocking p53 Activity

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Upregulation of Superenhancer‐Driven LncRNA FASRL by USF1 Promotes De Novo Fatty Acid Biosynthesis to Exacerbate Hepatocellular Carcinoma

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PPM1G promotes the progression of hepatocellular carcinoma via phosphorylation regulation of alternative splicing protein SRSF3

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Long noncoding RNA AVAN promotes antiviral innate immunity by interacting with TRIM25 and enhancing the transcription of FOXO3a

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LINC00261 suppresses human colon cancer progression via sponging miR‐324‐3p and inactivating the Wnt/β‐catenin pathway

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Baicalein inhibits breast cancer growth via activating a novel isoform of the long noncoding RNA PAX8‐AS1‐N

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Functional long non-coding RNAs in hepatocellular carcinoma

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The Long Intergenic Noncoding RNA 00707 Promotes Lung Adenocarcinoma Cell Proliferation and Migration by Regulating Cdc42

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Long noncoding RNA TTN-AS1 facilitates tumorigenesis and metastasis by maintaining TTN expression in skin cutaneous melanoma

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Role of long non-coding RNAs in cancer: From subcellular localization to nanoparticle-mediated targeted regulation

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Long non-coding RNA SBF2-AS1 promotes hepatocellular carcinoma progression through regulation of miR-140-5p-TGFBR1 pathway

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The natural compound neobractatin inhibits tumor metastasis by upregulating the RNA-binding-protein MBNL2

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Long Noncoding RNA PCED1B-AS1 Promotes the Warburg Effect and Tumorigenesis by Upregulating HIF-1α in Glioblastoma

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Multiple Roles of Exosomal Long Noncoding RNAs in Cancers

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Long noncoding RNA LINC01578 drives colon cancer metastasis through a positive feedback loop with the NF‐κB/YY1 axis

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Long noncoding RNA PXN-AS1-L promotes non-small cell lung cancer progression via regulating PXN

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LINC01128 expedites cervical cancer progression by regulating miR-383-5p/SFN axis

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ITGB1-DT Facilitates Lung Adenocarcinoma Progression via Forming a Positive Feedback Loop With ITGB1/Wnt/β-Catenin/MYC

Chang, R., Xiao, X., Fu, Y. S., Zhang, C., Zhu, X., & Gao, Y. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.631259 · Cited by 42 · see citing works

HCC-Related lncRNAs: Roles and Mechanisms

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Long noncoding RNA PXN‐AS1‐L promotes the malignancy of nasopharyngeal carcinoma cells via upregulation of SAPCD2

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ITGB1 Drives Hepatocellular Carcinoma Progression by Modulating Cell Cycle Process Through PXN/YWHAZ/AKT Pathways

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Long noncoding RNA HEGBC promotes tumorigenesis and metastasis of gallbladder cancer via forming a positive feedback loop with IL-11/STAT3 signaling pathway

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Transcriptome Sequencing Reveals the Differentially Expressed lncRNAs and mRNAs Involved in Cryoinjuries in Frozen-Thawed Giant Panda (Ailuropoda melanoleuca) Sperm

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Sodium new houttuyfonate suppresses metastasis in NSCLC cells through the Linc00668/miR-147a/slug axis

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Long non‐coding RNA LINC01535 promotes cervical cancer progression via targeting the miR‐214/EZH2 feedback loop

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Targeting long non-coding RNAs in cancer therapy using CRISPR-Cas9 technology: A novel paradigm for precision oncology

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Prediction of Overall Survival in Gastric Cancer Using a Nine-lncRNA

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Long noncoding RNA CNALPTC1 promotes cell proliferation and migration of papillary thyroid cancer via sponging miR-30 family.

Chen, C., Zhou, L., Wang, H., Chen, J., Li, W., Liu, W., Shen, M., Liu, H., & Fu, X. (2018) · PubMed Central · Cited by 38 · see citing works

Alternative splicing of lncRNAs in human diseases.

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ALKBH5 SUMOylation-mediated FBXW7 m6A modification regulates alveolar cells senescence during 1-nitropyrene-induced pulmonary fibrosis

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Alternative RNA Splicing in Fatty Liver Disease

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LRRC75A antisense lncRNA1 knockout attenuates inflammatory responses of bovine mammary epithelial cells

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Long non-coding RNA DANCR promotes cervical cancer growth via activation of the Wnt/β-catenin signaling pathway

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The patterns of antisense long non-coding RNAs regulating corresponding sense genes in human cancers

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Genomic amplification of long noncoding RNA HOTAIRM1 drives anaplastic thyroid cancer progression via repressing miR-144 biogenesis

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Paxillin actions in the nucleus

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Long noncoding RNA GIHCG functions as an oncogene and serves as a serum diagnostic biomarker for cervical cancer

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Multidimensional crosstalk between RNA-binding proteins and noncoding RNAs in cancer biology.

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The interplay between non-coding RNAs and alternative splicing: from regulatory mechanism to therapeutic implications in cancer

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Long Non-coding RNA SNHG12 Functions as a Competing Endogenous RNA to Regulate MDM4 Expression by Sponging miR-129-5p in Clear Cell Renal Cell Carcinoma

Wu, Z., Chen, D., Wang, K., Cao, C., & Xu, X. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.01260 · Cited by 32 · see citing works

LINC00667/miR-449b-5p/YY1 axis promotes cell proliferation and migration in colorectal cancer

Yu, J., Wang, F., Zhang, J., Li, J., Chen, X., & Han, G. (2020) · Cancer Cell International · doi:10.1186/s12935-020-01377-7 · Cited by 33 · see citing works

Lipid metabolism–related lncRNA SLC25A21‐AS1 promotes the progression of oesophageal squamous cell carcinoma by regulating the NPM1/c‐Myc axis and SLC25A21 expression

Liu, Y., Li, C., Fang, L., Wang, L., Liu, H., Tian, H., Zheng, Y., Fan, T. T., & He, J. (2022) · Clinical and Translational Medicine · doi:10.1002/ctm2.944 · Cited by 32 · see citing works

Distinct regulatory functions and biological roles of lncRNA splice variants

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Identification of The Aberrantly Expressed LncRNAs in Hepatocellular Carcinoma: A Bioinformatics Analysis Based on RNA-sequencing

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RNA splicing analysis in genomic medicine.

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Mechanism of long noncoding RNAs as transcriptional regulators in cancer

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Upregulation of lncRNA DARS‐AS1 accelerates tumor malignancy in cervical cancer by activating cGMP‐PKG pathway

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The Landscape of lncRNAs in Hepatocellular Carcinoma: A Translational Perspective

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Noncoding RNAs as sensors of tumor microenvironmental stress

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Alternative splicing related genetic variants contribute to bladder cancer risk

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Comprehensive analysis of differentially expressed long non‑coding RNAs in non‑small cell lung cancer

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Genome-Wide Identification and Characterization of Potato Long Non-coding RNAs Associated With Phytophthora infestans Resistance

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KLHDC7B-DT aggravates pancreatic ductal adenocarcinoma development via inducing cross-talk between cancer cells and macrophages

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FUT8-AS1 Inhibits the Malignancy of Melanoma Through Promoting miR-145-5p Biogenesis and Suppressing NRAS/MAPK Signaling

Chen, X., Liu, S., Han, D., Han, D., Sun, W., Zhao, X.-C., Liang, J., & Yu, L. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2020.586085 · Cited by 29 · see citing works

Function of the Long Noncoding RNAs in Hepatocellular Carcinoma: Classification, Molecular Mechanisms, and Significant Therapeutic Potentials

Khan, A., & Zhang, X. (2022) · Bioengineering · doi:10.3390/bioengineering9080406 · Cited by 28 · see citing works

Long non-coding RNA HOMER3-AS1 drives hepatocellular carcinoma progression via modulating the behaviors of both tumor cells and macrophages

Pu, J., Li, W., Wang, A., Zhang, Y., Qin, Z., Xu, Z., Wang, J., Lu, Y., Tang, Q., & Wei, H. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04309-z · Cited by 28 · see citing works

Long non-coding RNA BRE-AS1 represses non-small cell lung cancer cell growth and survival via up-regulating NR4A3

Zhang, M., Wu, J., Zhong, W., Zhao, Z., & Liu, Z. (2018) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2018.09.013 · Cited by 28 · see citing works

LINC01089 Inhibits Tumorigenesis and Epithelial–Mesenchymal Transition of Non-small Cell Lung Cancer via the miR-27a/SFRP1/Wnt/β-catenin Axis

Li, X., Lv, F., Fang, L., Du, M., Liang, Y., Ju, S., Liu, Z., Zhou, B., Wang, B., & Gao, Y. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.532581 · Cited by 27 · see citing works

Genome-wide identification and functional characterization of natural antisense transcripts in Salvia miltiorrhiza

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Noncoding RNA-chromatin association: Functions and mechanisms

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USP39 promotes hepatocellular carcinogenesis through regulating alternative splicing in cooperation with SRSF6/HNRNPC

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RBM39 promotes hepatocarcinogenesis by regulating RFX1’s alternative splicing and subsequent activation of integrin signaling pathway

Zhang, B., Zhou, Y., Xu, X., Xu, G., Wu, Z., Wu, Q., Zeng, Q., Yang, J., Lv, T., & Yang, J. (2025) · Oncogene · doi:10.1038/s41388-025-03327-x · Cited by 8 · see citing works

HnRNPR-mediated UPF3B mRNA splicing drives hepatocellular carcinoma metastasis

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Splicing Regulator p54nrb/Non–POU Domain–Containing Octamer‐Binding Protein Enhances Carcinogenesis Through Oncogenic Isoform Switch of MYC Box–Dependent Interacting Protein 1 in Hepatocellular Carcinoma

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Paradoxical overexpression of MBNL2 in hepatocellular carcinoma inhibits tumor growth and invasion

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