The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
A regulated PNUTS mRNA to lncRNA splice switch mediates EMT and tumour progression
Open accessAbstract
The contribution of lncRNAs to tumour progression and the regulatory mechanisms driving their expression are areas of intense investigation. Here, we characterize the binding of heterogeneous nuclear ribonucleoprotein E1 (hnRNP E1) to a nucleic acid structural element located in exon 12 of PNUTS (also known as PPP1R10) pre-RNA that regulates its alternative splicing. HnRNP E1 release from this structural element, following its silencing, nucleocytoplasmic translocation or in response to TGFβ, allows alternative splicing and generates a non-coding isoform of PNUTS. Functionally the lncRNA-PNUTS serves as a competitive sponge for miR-205 during epithelial–mesenchymal transition (EMT). In mesenchymal breast tumour cells and in breast tumour samples, the expression of lncRNA-PNUTS is elevated and correlates with levels of ZEB mRNAs. Thus, PNUTS is a bifunctional RNA encoding both PNUTS mRNA and lncRNA-PNUTS, each eliciting distinct biological functions. While PNUTS mRNA is ubiquitously expressed, lncRNA-PNUTS appears to be tightly regulated dependent on the status of hnRNP E1 and tumour context.
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LNCcation: lncRNA localization and function
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Exosomes: key players in cancer and potential therapeutic strategy
Dai, J., Su, Y., Zhong, S., Cong, L., Liu, B., Yang, J., Tao, Y., He, Z., Chen, C., & Jiang, Y. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00261-0 · Cited by 1,186
Metadata
- Authors
- Grelet, S., Link, L. A., Howley, B., Obellianne, C., Palanisamy, V., Gangaraju, V. K., Diehl, J. A., & Howe, P. H.
- Venue
- Nature Cell Biology
- Published
- 2017-08-21
- Volume
- 19
- Issue
- 9
- Pages
- 1105-1115
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- OpenAlex
- W2746147763
- Cited by
- 357
- References
- 44
- FWCI
- 10.07
- Type
- journal article
- Language
- en
- Open access
- green
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- Grelet, S., Link, L. A., Howley, B., Obellianne, C., Palanisamy, V., Gangaraju, V. K., Diehl, J. A., & Howe, P. H. (2017). A regulated PNUTS mRNA to lncRNA splice switch mediates EMT and tumour progression. Nature Cell Biology. https://doi.org/10.1038/ncb3595
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