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Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy
Open accessAbstract
Mechanisms by which autophagy promotes cell survival or death are unclear. We provide evidence that C(18)-pyridinium ceramide treatment or endogenous C(18)-ceramide generation by ceramide synthase 1 (CerS1) expression mediates autophagic cell death, independent of apoptosis in human cancer cells. C(18)-ceramide-induced lethal autophagy was regulated via microtubule-associated protein 1 light chain 3 β-lipidation, forming LC3B-II, and selective targeting of mitochondria by LC3B-II-containing autophagolysosomes (mitophagy) through direct interaction between ceramide and LC3B-II upon Drp1-dependent mitochondrial fission, leading to inhibition of mitochondrial function and oxygen consumption. Accordingly, expression of mutant LC3B with impaired ceramide binding, as predicted by molecular modeling, prevented CerS1-mediated mitochondrial targeting, recovering oxygen consumption. Moreover, knockdown of CerS1 abrogated sodium selenite-induced mitophagy, and stable LC3B knockdown protected against CerS1- and C(18)-ceramide-dependent mitophagy and blocked tumor suppression in vivo. Thus, these data suggest a new receptor function of ceramide for anchoring LC3B-II autophagolysosomes to mitochondrial membranes, defining a key mechanism for the induction of lethal mitophagy.
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“The localization of CerS1 to the mitochondria and the synthesis of ceramide in the outer mitochondrial membrane recruit the autophagic machinery and induce mitophagy (15) by binding autophagosome-associated LC3.”
From Alzheimer's Disease–Associated Amyloid-β Precursor Protein Prevents Aging Stress–Induced Mitophagy and Fumarate Depletion to Improve Antitumor Immunity (2025) · cites this paper as [15]
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Li, S. (2016) · Blood · doi:10.1182/blood-2016-08-735704
“Ceramide is known to regulate autophagy and induce lethal mitophagy.(9) However, a mechanistic link between FLT3-ITD signaling and ceramide metabolism for the regulation of mitophagydependent cell death in AML has not been established.”
BackgroundNovel Therapeutic Approaches to Induce Autophagy in Brain Cancer
Conway, G. E. (2016) · Arrow - TU Dublin (Technological University Dublin) · doi:10.21427/d7632v
Regulation of Mitochondrial Fission by Ceramide-induced Bcl-2-related Ovarian Killer in Preeclampsia
Ausman, J. (2017) · TSpace (University of Toronto)
Tan, S. (2017) · DR-NTU (Nanyang Technological University) · doi:10.32657/10356/72655
The Emerging Role of Autophagy in COPD
Mizumura, K. (2018) · Journal of Nihon University Medical Association · doi:10.4264/numa.77.2_115
Structural and Post-Transcriptional Regulation of Autophagy in Saccharomyces cerevisiae
Gatica, D. (2019) · Deep Blue (University of Michigan)
Relevance of Autophagy in Cancer Stem Cell and Therapeutic
Sinha, N. (2020) · Springer eBooks · doi:10.1007/978-981-15-6930-2_10
The role of plasma membrane lipids in plant stresses adaptation
Liu, Y. (2021) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-8396
Faculty Opinions recommendation of Sphingolipid metabolism in cancer signalling and therapy.
Loughran, T. P., & Tan, S. (2018) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.732125735.793546487
Mitochondrial dysfunction and its consequences in the context of neurodegeneration
Key, J. (2021) · Publication Server of Goethe University Frankfurt am Main (Goethe University Frankfurt) · doi:10.21248/gups.62414
Diehl, J. A. (2017) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.725967101.793538077
Klip, A., & Pillon, N. J. (2018) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.733852398.793550114
Estudo da proteína esfingosina quinase 2 em câncer de cabeça e pescoço
Fugio, L. B. (2022) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.60.2022.tde-18052022-081750
Alterations of Lipid-Mediated Mitophagy Result in Aging-Dependent Sensorimotor DefectsPreprint
Oleinik, N. V., Albayram, Ö., Kassir, M. F., Atilgan, F. C., Walton, C. M., Karakaya, E., Kurtz, J., Alekseyenko, A. V., Alsudani, H., Szulc, Z. M., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-2277978/v1
Self-citationRole of sphingolipids in inflammatory carciongensis
El-Hindi, K. (2022) · Publication Server of Goethe University Frankfurt am Main (Goethe University Frankfurt) · doi:10.21248/gups.71949
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ATG8 family protein, cargo selection, and autophagy
Mishra, A., & Dhiman, R. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-90142-0.00006-2
Functional omics of ORP7 in primary endothelial cellsPreprint
Taskinen, J. H., Holopainen, M., Ruhanen, H., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.03.19.585674
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Metadata
- Authors
- Sentelle, R. D., Senkal, C. E., Jiang, W., Ponnusamy, S., Gencer, S., Panneer Selvam, S., Ramshesh, V. K., Peterson, Y. K., Lemasters, J. J., Szulc, Z. M., Bielawski, J., & Ogretmen, B.
- Affiliations
- Medical University of South Carolina (US)
- Venue
- Nature Chemical Biology
- Published
- 2012-08-26
- Volume
- 8
- Issue
- 10
- Pages
- 831-838
- ISSN
- 1552-4450 (ISSN-L)
- 1552-4469
- PMC
- PMC3689583
- OpenAlex
- W1981224101
- Cited by
- 539
- References
- 44
- Citations by year
- 2026: 36 · 2025: 44 · 2024: 50 · 2023: 56 · 2022: 35 · 2021: 47 · 2020: 38 · 2019: 37 · 2018: 48 · 2017: 41 · 2016: 32 · 2015: 31 · 2014: 27 · 2013: 15 · 2012: 2
- FWCI
- 17.96
- Type
- journal article
- Language
- en
- Update notices
- erratum (2012-11-26)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Chemical Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (1c06rr015455-01a1)
- National Institute on Alcohol Abuse and Alcoholism (P50AA011605, 1-P50-AA11605)
- National Cancer Institute (CA088932, R01CA088932, CA097165, P30CA138313)
- National Institute of Diabetes and Digestive and Kidney Diseases (5P30 DK 34987, P30DK034987)
- National Institute of Dental and Craniofacial Research (DE-016572, R01DE016572)
- National Center for Research Resources (C06 RR-015455)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sphingolipid Metabolism and Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Keywords
- ceramide, mitophagy, autophagy, LC3B-II, LC3B lipidation, CERS1, autophagic cell death, Drp1, mitochondrial fission, autophagolysosomes, mitochondrial targeting, oxygen consumption, sodium selenite, tumor suppression, cancer cells
- MeSH terms
- Autophagy, Ceramides, Humans, Lipids, Phagosomes, Cell Death, Microscopy, Confocal, Cell Line, Tumor, Mitophagy
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