A propofol binding site on mammalian GABAA receptors identified by photolabeling

A statistical model for identifying proteins by tandem mass spectrometry.

Nesvizhskii, A., Keller, A., Kolker, E., & Aebersold, R. (2003) · Analytical Chemistry · doi:10.1021/ac0341261 · Cited by 4,902

General anaesthesia: from molecular targets to neuronal pathways of sleep and arousal

Franks, N. P. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2372 · Cited by 1,295

Principles of activation and permeation in an anion-selective Cys-loop receptor

Hibbs, R. E., & Gouaux, E. (2011) · Nature · doi:10.1038/nature10139 · Cited by 1,016

General anesthetic actions in vivo strongly attenuated by a point mutation in the GABA A receptor β3 subunit

Jurd, R., Arrasa, M., Lambert, S., Drexler, B., Siegwart, R., Crestani, F., Zaugg, M., Vogt, K. E., Ledermann, B., Antkowiak, B., et al. (2003) · The FASEB Journal · doi:10.1096/fj.02-0611fje · Cited by 558

Binding of the General Anesthetics Propofol and Halothane to Human Serum Albumin

Bhattacharya, A. A., Curry, S., & Franks, N. P. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005460200 · Cited by 529

X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel

Nury, H., Van Renterghem, C., Weng, Y., Tran, A., Baaden, M., Dufresne, V., Changeux, J.-P., Sonner, J. M., Delarue, M., & Corringer, P.-J. (2011) · Nature · doi:10.1038/nature09647 · Cited by 412

The actions of propofol on inhibitory amino acid receptors of bovine adrenomedullary chromaffin cells and rodent central neurones

Hales, T. G., & Lambert, J. J. (1991) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1991.tb12479.x · Cited by 345

Identification of a GABA A Receptor Anesthetic Binding Site at Subunit Interfaces by Photolabeling with an Etomidate Analog

Li, G., Chiara, D. C., Sawyer, G. W., Husain, S. S., Olsen, R. W., & Cohen, J. B. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3467-06.2006 · Cited by 289

A Single Glycine Residue at the Entrance to the First Membrane-Spanning Domain of the γ-Aminobutyric Acid Type A Receptor β2 Subunit Affects Allosteric Sensitivity to GABA and Anesthetics

Carlson, B. X., Engblom, A. C., Kristiansen, U., Schousboe, A., & Olsen, R. W. (2000) · Molecular Pharmacology · doi:10.1124/mol.57.3.474 · Cited by 270

Propofol and Other Intravenous Anesthetics Have Sites of Action on the γ-Aminobutyric Acid Type A Receptor Distinct from That for Isoflurane

Krasowski, M. D., Koltchine, V. V., Rick, C., Ye, Q., Finn, S. E., & Harrison, N. L. (1998) · Molecular Pharmacology · doi:10.1124/mol.53.3.530 · Cited by 250

Molecular mechanisms of the GABA type A receptor function

Michałowski, M. A., Kłopotowski, K., Wiera, G., Czyzewska, M. M., & Mozrzymas, J. W. (2025) · Quarterly Reviews of Biophysics · doi:10.1017/s0033583524000179 · Cited by 18

Molecular mode of action of CGS 9895 at α1β2γ2 GABAA receptors

Maldifassi, M. C., Baur, R., & Sigel, E. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13711 · Cited by 18

Propofol suppresses hypoxia‐induced esophageal cancer cell migration, invasion, and EMT through regulating lncRNA TMPO‐AS1 / miR ‐498 axis

Gao, M., Guo, R., Lu, X., Xu, G., & Luo, S. (2020) · Thoracic Cancer · doi:10.1111/1759-7714.13534 · Cited by 18

Coherence of Visual-Evoked Gamma Oscillations Is Disrupted by Propofol but Preserved Under Equipotent Doses of Isoflurane

Aggarwal, A., Brennan, C. M., Shortal, B. P., Contreras, D., Kelz, M. B., & Proekt, A. (2019) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2019.00019 · Cited by 17

Direct visualization of general anesthetic propofol on neurons by stimulated Raman scattering microscopy

Oda, R. W., Shou, J., Zhong, W., Ozeki, Y., Yasui, M., & Nuriya, M. (2022) · iScience · doi:10.1016/j.isci.2022.103936 · Cited by 17

A comparative study on the efficacy and safety of propofol combined with different doses of alfentanil in gastroscopy: a randomized controlled trial

Wang, L., Guan, Z.-Y., Wang, C., Zhang, Y., Zhang, J., & Zhao, P. (2022) · Journal of Anesthesia · doi:10.1007/s00540-022-03145-5 · Cited by 17

Dodecyl Maltopyranoside Enabled Purification of Active Human GABA Type A Receptors for Deep and Direct Proteomic Sequencing*

Zhang, X., & Miller, K. W. (2014) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m114.042556 · Cited by 17

Opposing Effects of the Anesthetic Propofol at Pentameric Ligand-Gated Ion Channels Mediated by a Common Site

Lynagh, T., & Laube, B. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.4307-13.2014 · Cited by 17

Three classes of propofol binding sites on GABAA receptors

Chen, Z.-W., Chintala, S. M., Bracamontes, J. R., Sugasawa, Y., Pierce, S. R., Varga, B. R., Smith, E. H., Edge, C. J., Franks, N. P., Cheng, W. W. L., et al. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.107778 · Cited by 16

Photoaffinity Labeling the Propofol Binding Site in GLIC

Chiara, D. C., Chen, Q., Tillman, T. S., Gill, J. F., Dailey, W. P., Eckenhoff, R. G., Xu, Y., Tang, P. S., & Cohen, J. B. (2013) · Biophysical Journal · doi:10.1016/j.bpj.2012.11.3513 · Cited by 16

Claustrum modulates behavioral sensitivity and EEG activity of propofol anesthesia

Luo, T., Li, L., Li, J., Cai, S., Wang, Y., Zhang, L., Yu, S., & Yu, T. (2022) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14012 · Cited by 16

A protet-based, protonic charge transfer model of energy coupling in oxidative and photosynthetic phosphorylation

Kell, D. B. (2021) · Advances in microbial physiology/Advances in Microbial Physiology · doi:10.1016/bs.ampbs.2021.01.001 · Cited by 16

Mechanisms of Drug Action

Proekt, A., & Hemmings, H. C. (2018) · Elsevier eBooks · doi:10.1016/b978-0-323-48110-6.00001-6 · Cited by 17

β subunits of GABAA receptors form proton-gated chloride channels: Insights into the molecular basis

Garifulina, A. I., Friesacher, T., Stadler, M., Zangerl‐Plessl, E., Ernst, M. C., Stary‐Weinzinger, A., Willam, A., & Hering, S. (2022) · Communications Biology · doi:10.1038/s42003-022-03720-2 · Cited by 15

Phenols and GABAA receptors: from structure and molecular mechanisms action to neuropsychiatric sequelae

Menzikov, S. A., Zaichenko, D. M., Московцев, А. А., Morozov, S., & Kubatiev, A. A. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1272534 · Cited by 18

Fluorierte Reagenzien in der Strukturproteomik

Cheng, M., Guo, C., & Gross, M. L. (2019) · Angewandte Chemie · doi:10.1002/ange.201907662 · Cited by 14

Xanthine-based photoaffinity probes allow assessment of ligand engagement by TRPC5 channels

Bauer, C. C., Minard, A., Pickles, I. B., Simmons, K. J., Chuntharpursat‐Bon, E., Burnham, M. P., Kapur, N., Beech, D. J., Muench, S. P., Wright, M. H., et al. (2020) · RSC Chemical Biology · doi:10.1039/d0cb00126k · Cited by 14

A Cysteine Substitution Probes β3H267 Interactions with Propofol and Other Potent Anesthetics in α1β3γ2L γ-Aminobutyric Acid Type A Receptors

Stern, A. T., & Forman, S. A. (2015) · Anesthesiology · doi:10.1097/aln.0000000000000934 · Cited by 14

Laser‐Initiated Radical Trifluoromethylation of Peptides and Proteins: Application to Mass‐Spectrometry‐Based Protein Footprinting

Cheng, M., Zhang, B., Cui, W., & Gross, M. L. (2017) · Angewandte Chemie · doi:10.1002/ange.201706697 · Cited by 14

Insights into the Nature of Anesthetic–Protein Interactions: An ONIOM Study

Qiu, L., Lin, J., & Bertaccini, E. J. (2015) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.5b05897 · Cited by 13

Location and Character of Volatile General Anesthetics Binding Sites in the Transmembrane Domain of TRPV1

Jorgensen, C., & Domene, C. (2018) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.8b00381 · Cited by 13

A Potential Mechanism of Sodium Channel Mediating the General Anesthesia Induced by Propofol

Xiao, J., Chen, Z., & Yu, B. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.593050 · Cited by 13

Detergents: Friends not foes for high‐performance membrane proteomics toward precision medicine

Zhang, X. (2016) · PROTEOMICS · doi:10.1002/pmic.201600209 · Cited by 14

Norepinephrine modulates wakefulness via α1 adrenoceptors in paraventricular thalamic nucleus

Wang, Y., Xu, L., Liu, M., Hu, D.-D., Fang, F., Xu, D., Zhang, R., Hua, X.-X., Li, J., Zhang, L., et al. (2021) · iScience · doi:10.1016/j.isci.2021.103015 · Cited by 14

Fluorinated Aliphatic Diazirines: Preparation, Characterization, and Model Photolabeling Studies

Kornii, Y., Shablykin, O. V., Tarasiuk, T. M., Stepaniuk, O., Matvienko, V., Aloshyn, D., Zahorodniuk, N., Sadkova, I. V., & Mykhailiuk, P. K. (2022) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.2c02262 · Cited by 12

Propofol Requirement for Induction of Unconsciousness Is Reduced in Patients with Parkinson’s Disease: A Case Control Study

Xu, X., Yu, X., Wu, X. L., Hu, X., Chen, J., Li, J., Wang, J., & Deng, X. (2015) · BioMed Research International · doi:10.1155/2015/953729 · Cited by 12

Membrane nanodomains homeostasis during propofol anesthesia as function of dosage and temperature

Jin, W., Zucker, M., & Pralle, A. (2020) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2020.183511 · Cited by 12

GABAA Receptor Modulation by Phenyl Ring Compounds Is Associated with a Water Solubility Cut-Off Value

Brosnan, R. J., & Pham, T. L. (2016) · Pharmacology · doi:10.1159/000444935 · Cited by 12

Paths to Oblivion: Common Neural Mechanisms of Anaesthesia and Disorders of ConsciousnessPreprint

Luppi, A. I., Mediano, P. A. M., Rosas, F. E., Allanson, J. E., Pickard, J. D., Williams, G. B., Craig, M. M., Finoia, P., Peattie, A. R. D., Coppola, P., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.02.14.431140 · Cited by 12

Propofol activates AMPK to inhibit the growth of HepG2 cells in vitro and hepatocarcinogenesis in xenograft mouse tumor models by inducing autophagy

Wang, Y., Xu, B., Zhou, J., & Wu, X. (2020) · Journal of Gastrointestinal Oncology · doi:10.21037/jgo-20-472 · Cited by 10

Orexin-B antagonized respiratory depression induced by sevoflurane, propofol, and remifentanil in isolated brainstem-spinal cords of neonatal rats

Umezawa, N., Arisaka, H., Sakuraba, S., Sugita, T., Matsumoto, A., Kaku, Y., Yoshida, K.-I., & Kuwana, S. (2014) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2014.10.013 · Cited by 12

Selective synthesis of propofol (2,6-diisopropylphenol), an intravenous anesthetic drug, by isopropylation of phenol over H-beta and H-mordenite

Nandiwale, K. Y., & Bokade, V. V. (2014) · RSC Advances · doi:10.1039/c4ra03004d · Cited by 11

Novel positive allosteric modulators of GABAA receptors with anesthetic activity

Maldifassi, M. C., Baur, R., Pierce, D. W., Nourmahnad, A., Forman, S. A., & Sigel, E. (2016) · Scientific Reports · doi:10.1038/srep25943 · Cited by 11

Discovery of the EL-0052 as a potential anesthetic drug

Jiang, J., Xu, X., Jiang, W., Wang, T., Liu, X., Zeng, L.-G., Liao, J. M., Xiu, J., Shen, Y., Deng, P., et al. (2021) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2021.01.002 · Cited by 10

Modulation of α1β3γ2 GABA A receptors expressed in X. laevis oocytes using a propofol photoswitch tethered to the transmembrane helix

Borghese, C. M., Wang, H. L., McHardy, S. F., Messing, R. O., Trudell, J. R., Harris, R. A., & Bertaccini, E. J. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2008178118 · Cited by 10

Competitive Interactions Between Propofol and Diazepam: Studies in GABAA Receptors and Zebrafish

Pence, A., Hoyt, H., McGrath, M., Forman, S. A., & Raines, D. E. (2022) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.122.001337 · Cited by 10

Design, Synthesis, and Biological Evaluation of Beauveriolide Analogues Bearing Photoreactive Amino Acids

Masuda, Y., Aoyama, K., Yoshida, M., Kobayashi, K., Ohshiro, T., Tomoda, H., & Doi, T. (2016) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.c16-00095 · Cited by 10

Multisite Labeling of Proteins Using the Ligand-Directed Reactivity of Triggerable Michael Acceptors

Kurbanov, M., Kirsch, Z. J., Krishna, J., Dutta, R., Vachet, R. W., & Thayumanavan, S. (2023) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.3c00155 · Cited by 9

Repurposing electroencephalogram monitoring of general anaesthesia for building biomarkers of brain ageing: an exploratory study

Sabbagh, D., Cartailler, J., Touchard, C., Joachim, J., Mebazaa, A., Vallée, F., Gayat, É., Gramfort, A., & Engemann, D. A. (2023) · BJA Open · doi:10.1016/j.bjao.2023.100145 · Cited by 9

Novel applications of sleep pharmacology as delirium therapeutics

Oldham, C. M., Spira, A. P., Yurcheshen, M. E., Pigeon, W. R., Palanca, B. J. A., & Lee, H. B. (2024) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2024.102016 · Cited by 9

Unbiased Mass Spectrometry Elucidation of the Targets and Mechanisms of Activity-Based Probes: A Case Study Involving Sulfonyl Fluorides

Chavas, T. E. J., Fuchter, M. J., & DiMaggio, P. A. (2018) · ACS Chemical Biology · doi:10.1021/acschembio.8b00530 · Cited by 8

Syntheses of Analogues of Propofol: A Review

Dimitrov, I. V., & Suonio, E. (2020) · Synthesis · doi:10.1055/s-0040-1707287 · Cited by 8

Azi-medetomidine: Synthesis and Characterization of a Novel α2 Adrenergic Photoaffinity Ligand

McKinstry-Wu, A. R., Woll, K. A., Joseph, T. T., Bu, W., White, E. R., Bhanu, N. V., Garcia, B. A., Brannigan, G. H., Dailey, W. P., & Eckenhoff, R. G. (2019) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.9b00484 · Cited by 8

Synthesis and Characterization of a Diazirine-Based Photolabel of the Nonanesthetic Fropofol

White, E. R., Leace, D. M., Bedell, V. M., Bhanu, N. V., Garcia, B. A., Dailey, W. P., & Eckenhoff, R. G. (2020) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.0c00667 · Cited by 8

Ion Channels in Anesthesia

Zhou, W., & Guan, Z. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-981-16-4254-8_19 · Cited by 9

Generation of Recombinant Antibodies to Rat GABAA Receptor Subunits by Affinity Selection on Synthetic Peptides

Koduvayur, S. P., Gussin, H. A., Parthasarathy, R., Hao, Z., Kay, B. K., & Pepperberg, D. R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087964 · Cited by 8

Phosphatidylinositol 4,5-bisphosphate depletion fails to affect neurosteroid modulation of GABAA receptor function

Mennerick, S. J., Taylor, A., & Zorumski, C. F. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3486-5 · Cited by 8

Neonatal Propofol and Etomidate Exposure Enhance Inhibitory Synaptic Transmission in Hippocampal Cornus Ammonis 1 Pyramidal Neurons

Zhang, J., Xu, W., & Xu, C. (2016) · Chinese Medical Journal · doi:10.4103/0366-6999.193459 · Cited by 8

Anticonvulsant effect of dipropofol by enhancing native GABA currents in cortical neurons in mice

Zhang, J., Chen, X., Kårbø, M., Zhao, Y., An, L., Wang, R., Wang, K., & Huang, Z. (2018) · Journal of Neurophysiology · doi:10.1152/jn.00241.2018 · Cited by 8

Cu 2 O nanoparticles anchored on carbon for the efficient removal of propofol from operating room wastewater via peroxymonosulfate activation: efficiency, mechanism, and pathway

Tang, Y., Zhao, S., Peng, Z., Li, Z., Chen, L., & Gan, P. (2021) · RSC Advances · doi:10.1039/d1ra03049c · Cited by 8

Investigating γ-secretase protein interactions in live cells using active site-directed clickable dual-photoaffinity probes

Ballard, T. E., Murrey, H. E., Geoghegan, K. F., Ende, C. W. A., & Johnson, D. S. (2013) · MedChemComm · doi:10.1039/c3md00283g · Cited by 8

Identification of amino acids involved in histamine potentiation of GABAA receptors

Thiel, U., Platt, S. J., Wolf, S., Hatt, H. H., & Gisselmann, G. ⁄. N. (2015) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00106 · Cited by 7

Mapping the Orthosteric Binding Site of the Human 5-HT3 Receptor Using Photo-cross-linking Antagonists

Jack, T., Leuenberger, M., Ruepp, M., Vernekar, S. K. V., Thompson, A. J., Braga-Lagache, S., Heller, M., & Lochner, M. (2018) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00327 · Cited by 7

Differential Potency of 2,6-Dimethylcyclohexanol Isomers for Positive Modulation of GABAA Receptor Currents

Chowdhury, L., Croft, C. J., Goel, S., Zaman, N., Tai, A. C.-S., Walch, E. M., Smith, K., Page, A., Shea, K. M., Hall, C. D., et al. (2016) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.115.228890 · Cited by 7

Inter- and Intra-Subunit Butanol/Isoflurane Sites of Action in the Human Glycine Receptor

McCracken, M. L., Gorini, G., McCracken, L. M., Mayfield, R. D., Harris, R. A., & Trudell, J. R. (2016) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2016.00045 · Cited by 7

Interactions of Propofol With Human Voltage-gated Kv1.5 Channel Determined by Docking Simulation and Mutagenesis Analyses

Kojima, A., Fukushima, Y., Ito, Y., Ding, W., Ueda, R., Seto, T., Kitagawa, H., & Matsuura, H. (2017) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000538 · Cited by 7

Handgrip dynamometry for continuous assessment of volitional control during induction of anesthesia: a prospective observational study

Guay, C. S., & Plourde, G. (2018) · Canadian Journal of Anesthesia/Journal canadien d anesthésie · doi:10.1007/s12630-018-1224-x · Cited by 7

A potent photoreactive general anesthetic with novel binding site selectivity for GABAA receptors

Shalabi, A. R., Yu, Z., Zhou, X., Jounaïdi, Y., Chen, H., Dai, J., Kent, D. E., Feng, H., Forman, S. A., Cohen, J. B., et al. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112261 · Cited by 7

Early developmental effects of propofol exposure in different stages of zebrafish embryos

Félix, L. M., Campos, S., de Pinho, P. G., Antunes, L. M., & Valentim, A. M. (2024) · Toxicology Letters · doi:10.1016/j.toxlet.2024.12.002 · Cited by 6

α5GABAA receptor: A potential therapeutic target for perioperative neurocognitive disorders, a review of preclinical studies

Xin, Y., Chu, T., Zhou, S., & Xu, A. (2023) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2023.110821 · Cited by 6

The effect of propofol on effective brain networks

van Blooijs, D., Blok, S., Huiskamp, G. J. M., van Eijsden, P., Meijer, H. G. E., & Leijten, F. S. S. (2024) · Clinical Neurophysiology · doi:10.1016/j.clinph.2024.01.012 · Cited by 6

High Constitutive Activity Accounts for the Combination of Enhanced Direct Activation and Reduced Potentiation in Mutated GABAA Receptors

Germann, A. L., Shin, D. J., Kuhrau, C. R., Johnson, A. D., Evers, A. S., & Akk, G. (2018) · Molecular Pharmacology · doi:10.1124/mol.117.111435 · Cited by 6

Do amino acids prefer only certain backbone structures? Steering through the conformational maze of l-threonine using matrix isolation infrared spectroscopy and ab initio studies

Dubey, P., Mukhopadhyay, A., & Viswanathan, K. S. (2018) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2018.07.066 · Cited by 6

Mechanisms of Drug Action

Proekt, A., & Hemmings, H. C. (2013) · Elsevier eBooks · doi:10.1016/b978-1-4377-1679-5.00001-6 · Cited by 7

Dynamical structure-function correlations provide robust and generalizable signatures of consciousness in humansPreprint

Castro, P., Luppi, A. I., Tagliazucchi, E., Perl, Y. S., Naçi, L., Owen, A. M., Sitt, J. D., Alain Destexhe, A., & Cofré, R. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.12.19.572402 · Cited by 6

Native System and Cultured Cell Electrophysiology for Investigating Anesthetic Mechanisms

Hoerbelt, P., & Heifets, B. D. (2018) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2018.01.012 · Cited by 5

A synthetic peptide rescues rat cortical neurons from anesthetic-induced cell death, perturbation of growth and synaptic assembly

Iqbal, F., Pehar, M., Thompson, A. J., Azeem, U., Jahanbakhsh, K., Jiménez-Téllez, N., Sabouny, R., Batool, S., Syeda, A., Chow, J., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-84168-y · Cited by 6

GABAA Receptor Genetics and Clinical Pharmacology

Davies, P. A. (2014) · Current anesthesiology reports · doi:10.1007/s40140-013-0046-1 · Cited by 5

Development of Photoactivatable Allosteric Modulators for the Chemokine Receptor CXCR3

Admas, T. H., Bernat, V., Heinrich, M. R., & Tschammer, N. (2016) · ChemMedChem · doi:10.1002/cmdc.201500573 · Cited by 5

Agonist and antagonist properties of an insect GABA-gated chloride channel (RDL) are influenced by heterologous expression conditions

Smelt, C. L. C., Sanders, V. R., Puinean, A. M., Lansdell, S. J., Goodchild, J., & Millar, N. S. (2021) · PLoS ONE · doi:10.1371/journal.pone.0254251 · Cited by 5

Propofol at Single Bolus and Continuous Rate Infusion Significantly Increases Serum Triglycerides, but not Cholesterol, In Healthy Bitches Undergoing Elective Ovariohysterectomy

Chagas, M., Custodio, L., Gusmão, B. S., Costa, I., Julião, G. H., Bordolini, S., Costa, L., Bosculo, M. R. M., Moreira, T., Almeida, B. F. M., et al. (2021) · Topics in companion animal medicine · doi:10.1016/j.tcam.2021.100560 · Cited by 5

In VivoPhotoadduction of Anesthetic Ligands in Mouse Brain Markedly Extends Sedation and Hypnosis

McKinstry-Wu, A. R., Wasilczuk, A. Z., Dailey, W. P., Eckenhoff, R. G., & Kelz, M. B. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.1884-22.2023 · Cited by 5

Photoaffinity Labeling of Pentameric Ligand-Gated Ion Channels: A Proteomic Approach to Identify Allosteric Modulator Binding Sites

Jayakar, S. S., Ang, G., Chiara, D. C., & Hamouda, A. K. (2017) · Methods in molecular biology · doi:10.1007/978-1-4939-6952-4_7 · Cited by 5

Instant Integrated Ultradeep Quantitative-structural Membrane Proteomics Discovered Post-translational Modification Signatures for Human Cys-loop Receptor Subunit Bias

Zhang, X. (2016) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m114.047514 · Cited by 5

A propofol binding site in the voltage sensor domain mediates inhibition of HCN1 channel activity

Burtscher, V., Wang, L., Cowgill, J. B., Chen, Z.-W., Edge, C., Smith, E., Chang, Y., Delemotte, L., Evers, A. S., & Chanda, B. (2025) · Science Advances · doi:10.1126/sciadv.adr7427 · Cited by 4

Dronedarone Modulates M1 and M3 Muscarinic Receptors with Subtype Selectivity, Functional Selectivity, and Probe Dependence

Jayasuriya, G. M., Elmslie, G., Burstein, E. S., & Ellis, J. (2016) · Pharmacology · doi:10.1159/000453362 · Cited by 3

Photoswitchable Ion Channels and Receptors

Bautista-Barrufet, A., Izquierdo-Serra, M., & Gorostiza, P. (2014) · Advances in atom and single molecule machines · doi:10.1007/978-3-662-43367-6_9 · Cited by 4

Mapping Pharmacologically-induced Functional Reorganisation onto the Brain’s Neurotransmitter LandscapePreprint

Luppi, A., Hansen, J. Y., Adapa, R., Carhart-Harris, R., Roseman, L., Timmermann, C., Golkowski, D., Ranft, A., Ilg, R., Jordan, D., et al. (2022) · bioRxiv · doi:10.1101/2022.07.12.499688 · Cited by 4

Evaluation of site-selective drug effects on GABA receptors using nanovesicle-carbon nanotube hybrid devices

Park, I., Yang, I., Cho, Y., Choi, Y. J., Shin, J., Shekhar, S., Lee, S. H., & Hong, S. (2021) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2021.113903 · Cited by 3

Mechanism of human α3β GlyR regulation by intracellular M3/M4 loop phosphorylation and 2,6-di-tert-butylphenol interaction

Liu, X., Krezel, M., & Wang, W. (2025) · Nature Communications · doi:10.1038/s41467-025-60516-8 · Cited by 3

Different effects of etomidate and propofol on memory in immature rats

Jiang, Y., Ni, X.-Q., Xiong, W.-W., Wang, H., Tan, Y., Huang, Z., & Yao, X. (2014) · International Journal of Neuroscience · doi:10.3109/00207454.2014.901968 · Cited by 3

Transcranial magnetic stimulation tracks subminute changes in cortical excitability during propofol anesthesia

Gersner, R., Paredes, C., Hameed, M. Q., Dhamne, S. C., Pascual‐Leone, Á., & Rotenberg, A. (2020) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.50981 · Cited by 3

Competitive dewetting underlies site-specific binding of general anesthetics to GABA(A) receptorsPreprint

Murlidaran, S., Hénin, J., & Brannigan, G. H. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/694612 · Cited by 3

Repurposing EEG monitoring of general anaesthesia for building biomarkers of brain ageing: An exploratory studyPreprint

Sabbagh, D., Cartailler, J., Touchard, C., Joachim, J., Mebazaa, A., Vallée, F., Gayat, É., Gramfort, A., & Engemann, D. A. (2022) · medRxiv · doi:10.1101/2022.05.05.22274610 · Cited by 3

Presynaptic Neurotransmission: A Bottleneck to Recovery From General Anesthesia?

van Zundert, A. A. J., Cylinder, D. M., & van Swinderen, B. (2025) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000007695 · Cited by 2

Orthosteric- versus allosteric-dependent activation of the GABAA receptor requires numerically distinct subunit level rearrangements

Αmin, J., & Subbarayan, M. S. (2017) · Scientific Reports · doi:10.1038/s41598-017-08031-9 · Cited by 3

X-Ray Crystallographic Studies for Revealing Binding Sites of General Anesthetics in Pentameric Ligand-Gated Ion Channels

Chen, Q., Xu, Y., & Tang, P. S. (2018) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2018.01.017 · Cited by 2

Optoanesthesia: Use of Anesthetic Photolabels In Vivo

McKinstry-Wu, A. R., & Kelz, M. B. (2018) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2018.01.021 · Cited by 2

Comparative studies on the binding site of anesthetics to GABA a receptors using in silico docking methods

Ahn, S., LEE, J.-Y., Sung, J., Kim, H. J., & PARK, S. (2023) · Biocell · doi:10.32604/biocell.2023.027984 · Cited by 1

Methodology for the analysis of etomidate and its enantiomer by HPLC

Peikova, L., Koleva, P., Balkanski, S. V., Valtchev, V., & Choparinova, P. (2025) · Pharmacia · doi:10.3897/pharmacia.72.e161975 · Cited by 1

Silapropofol: Carbon–Silicon Isosterism in a Key Anesthetic Scaffold

Koschabek, S., Kleemiss, F., Espinosa-Jalapa, N. Á., & Bauer, J. O. (2026) · ACS Omega · doi:10.1021/acsomega.5c11217 · Cited by 2

Effect of Subhypnotic Dose of Propofol on Respiratory Adverse Events Following Postoperative Tonsillectomy/Adenotosillecomy: A Systematic Review and Meta-Analysis

Albannai, N., Esmaeel, A., Alsaif, D., Alabdulrazzaq, F., Alshammari, S., Alharran, A. M., Almulla, E., & Abdulrahman, S. (2026) · Journal of Clinical Medicine · doi:10.3390/jcm15052074 · Cited by 1

Safe and successful use of remimazolam for gastrointestinal endoscopy in a patient with propofol-induced seizure-like phenomena: a case report and literature review

Zhao, J., Yan, C., chen, T., Xu, J., & Zhu, J. (2026) · BMC Anesthesiology · doi:10.1186/s12871-026-03805-z · Cited by 1

Photoaffinity Labeling in Drug Discovery Research

Muranaka, H., Momose, T., Handa, C., & Ozawa, T. (2017) · Springer eBooks · doi:10.1007/978-4-431-56569-7_12 · Cited by 1

Emergence Delirium

Proekt, A. (2019) · Cambridge University Press eBooks · doi:10.1017/9781316402504.002 · Cited by 2

Comparison of Half-Effective Concentration of Propofol in Patients with Parkinson’s Disease and Non-Parkinson’s Disease

Wang, P., Zhao, L., Wang, T., Mei, W., Li, J., An, Y., Li, L., & Li, Z. (2023) · Clinical Interventions in Aging · doi:10.2147/cia.s380416 · Cited by 1

Intravenous Hypnotic Agents: From Binding Sites to Loss of Consciousness

Baldassarre, D., Oliva, F., & Piazza, O. (2019) · Neuromethods · doi:10.1007/978-1-4939-9891-3_7 · Cited by 1

Efficient and flexible synthesis of new photoactivatable propofol analogs

Skinner, K. A., Wzorek, J. S., Kahne, D. E., & Gaudet, R. (2021) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2021.127927 · Cited by 1

Modulating Sirtuin Activity - Design, Synthesis and Evaluation of Sirtuin 2 Inhibitors

Seifert, T. (2014) · Gothenburg University Publications Electronic Archive (Gothenburg University)

Isoelectronic games: the CO analogue of diazirines as an intriguing species?

Rzepa, H. S. (2015) · doi:10.59350/9b8by-g0221

Identifying the Propofol Binding Site(S) in Heterologously Expressed Human Alpha1 Beta3 Gaba-A Receptors using a Photoreactive Propofol Analog

Jayakar, S. S., Zhou, X., Dostalova, Z., Dailey, W. P., Miller, K. W., Eckenhoff, R. G., & Cohen, J. B. (2013) · Biophysical Journal · doi:10.1016/j.bpj.2012.11.3519 · Cited by 1

Multiple Propofol-binding Sites in a γ-Aminobutyric Acid Type A Receptor (GABAAR) Identified Using a Photoreactive Propofol Analog

Jayakar, S. S., Zhou, X., Chiara, D. C., Dostalova, Z., Savechenkov, P. Y., Bruzik, K. S., Dailey, W. P., Miller, K. W., Eckenhoff, R. G., & Cohen, J. B. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.581728 · Cited by 118

Identifying Drugs that Bind Selectively to Intersubunit General Anesthetic Sites in the α1β3γ2 GABAAR Transmembrane Domain

Jayakar, S. S., Zhou, X., Chiara, D. C., Jarava‐Barrera, C., Savechenkov, P. Y., Bruzik, K. S., Tortosa, M., Miller, K. W., & Cohen, J. B. (2019) · Molecular Pharmacology · doi:10.1124/mol.118.114975 · Cited by 21

Three classes of propofol binding sites on GABAA receptors

Chen, Z.-W., Chintala, S. M., Bracamontes, J. R., Sugasawa, Y., Pierce, S. R., Varga, B. R., Smith, E. H., Edge, C. J., Franks, N. P., Cheng, W. W. L., et al. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.107778 · Cited by 16

A Novel Bifunctional Alkylphenol Anesthetic Allows Characterization of γ-Aminobutyric Acid, Type A (GABAA), Receptor Subunit Binding Selectivity in Synaptosomes

Woll, K. A., Murlidaran, S., Pinch, B. J., Hénin, J., Wang, X., Salari, R., Covarrubias, M., Dailey, W. P., Brannigan, G. H., Garcia, B. A., et al. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.736975 · Cited by 36