X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel

VMD: visual molecular dynamics

Humphrey, W., Dalke, A., & Schulten, K. (1996) · Journal of Molecular Graphics · doi:10.1016/0263-7855(96)00018-5 · Cited by 66,952 · see citing works

<i>Coot</i> : model-building tools for molecular graphics

Emsley, P., & Cowtan, K. (2004) · Acta Crystallographica Section D Biological Crystallography · doi:10.1107/s0907444904019158 · Cited by 30,571 · see citing works

Particle mesh Ewald: An N⋅log(N) method for Ewald sums in large systems

Darden, T., York, D., & Pedersen, L. (1993) · The Journal of Chemical Physics · doi:10.1063/1.464397 · Cited by 29,588 · see citing works

The PyMOL Molecular Graphics System

DeLano, W. L. (2002) · Medical Entomology and Zoology · Cited by 18,147 · see citing works

The CCP4 suite: programs for protein crystallography

Number Collaborative Computational Project (1994) · Acta Crystallographica Section D Biological Crystallography · doi:10.1107/s0907444994003112 · Cited by 17,299 · see citing works

Scalable molecular dynamics with NAMD

Phillips, J. C., Braun, R., Wang, W., Gumbart, J., Tajkhorshid, E., Villa, E., Chipot, C., Skeel, R. D., Kalé, L., & Schulten, K. (2005) · Journal of Computational Chemistry · doi:10.1002/jcc.20289 · Cited by 16,914 · see citing works

Refinement of Macromolecular Structures by the Maximum-Likelihood Method

Murshudov, G. N., Vagin, A. A., & Dodson, E. J. (1997) · Acta Crystallographica Section D Biological Crystallography · doi:10.1107/s0907444996012255 · Cited by 14,671 · see citing works

All-Atom Empirical Potential for Molecular Modeling and Dynamics Studies of Proteins

MacKerell, A. D., Bashford, D., Bellott, M., Dunbrack, R. L., Evanseck, J. D., Field, M. J., Fischer, S., Gao, J., Guo, H., Ha, S., et al. (1998) · The Journal of Physical Chemistry B · doi:10.1021/jp973084f · Cited by 14,270 · see citing works

PRODRG: a tool for high-throughput crystallography of protein–ligand complexes

Schüttelkopf, A. W., & van Aalten, D. M. F. (2004) · Acta Crystallographica Section D Biological Crystallography · doi:10.1107/s0907444904011679 · Cited by 4,815 · see citing works

MolProbity: all-atom contacts and structure validation for proteins and nucleic acids

Davis, I., Leaver‐Fay, A., Chen, V. B., Block, J. N., Kapral, G. J., Wang, X., Murray, L. W., Arendall, W. B., Snoeyink, J. S., Richardson, J. S., et al. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm216 · Cited by 3,915 · see citing works

Reversible multiple time scale molecular dynamics

Tuckerman, M. E., Berne, B. J., & Martyna, G. J. (1992) · The Journal of Chemical Physics · doi:10.1063/1.463137 · Cited by 3,566 · see citing works

Automatic processing of rotation diffraction data from crystals of initially unknown symmetry and cell constants

Kabsch, W. (1993) · Journal of Applied Crystallography · doi:10.1107/s0021889893005588 · Cited by 3,562 · see citing works

Oogenesis in Xenopus laevis (Daudin). I. Stages of oocyte development in laboratory maintained animals

Dumont, J. N. (1972) · Journal of Morphology · doi:10.1002/jmor.1051360203 · Cited by 1,858 · see citing works

Structure and gating mechanism of the acetylcholine receptor pore

Miyazawa, A., Fujiyoshi, Y., & Unwin, N. C. (2003) · Nature · doi:10.1038/nature01748 · Cited by 1,271 · see citing works

General anaesthesia: from molecular targets to neuronal pathways of sleep and arousal

Franks, N. P. (2008) · Nature reviews. Neuroscience · doi:10.1038/nrn2372 · Cited by 1,266 · see citing works

Sites of alcohol and volatile anaesthetic action on GABAA and glycine receptors

Mihic, S. J., Ye, Q., Wick, M. J., Koltchine, V. V., Krasowski, M. D., Finn, S. E., Mascia, M. P., Valenzuela, C. F., Hanson, K. K., Greenblatt, E. P., et al. (1997) · Nature · doi:10.1038/38738 · Cited by 1,219 · see citing works

Endogenous neurosteroids regulate GABAA receptors through two discrete transmembrane sites

Hosie, A. M., Wilkins, M. E., da Silva, H. M. A., & Smart, T. G. (2006) · Nature · doi:10.1038/nature05324 · Cited by 752 · see citing works

Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system

Taly, A., Corringer, P., Guédin, D., Lestage, P. J., & Changeux, J. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2927 · Cited by 706 · see citing works

X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation

Bocquet, N., Nury, H., Baaden, M., Poupon, C. L., Changeux, J., Delarue, M. H., & Corringer, P. (2008) · Nature · doi:10.1038/nature07462 · Cited by 674 · see citing works

X-ray structure of a prokaryotic pentameric ligand-gated ion channel

Hilf, R. J. C., & Dutzler, R. (2008) · Nature · doi:10.1038/nature06717 · Cited by 665 · see citing works

Do general anaesthetics act by competitive binding to specific receptors?

Franks, N. P., & Lieb, W. R. (1984) · Nature · doi:10.1038/310599a0 · Cited by 572 · see citing works

Binding of the General Anesthetics Propofol and Halothane to Human Serum Albumin

Bhattacharya, A. A., Curry, S., & Franks, N. P. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005460200 · Cited by 529 · see citing works

Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel

Hilf, R. J. C., & Dutzler, R. (2008) · Nature · doi:10.1038/nature07461 · Cited by 526 · see citing works

Mutations in the channel domain alter desensitization of a neuronal nicotinic receptor

Revah, F., Bertrand, D., Galzi, J., Devillers‐Thiéry, A., Mulle, C., Hussy, N., Bertrand, S., Ballivet, M., & Changeux, J. (1991) · Nature · doi:10.1038/353846a0 · Cited by 524 · see citing works

Fast empirical pKa prediction by Ewald summation

Krieger, E., Nielsen, J. E., Spronk, C. A. E. M., & Vriend, G. (2006) · Journal of Molecular Graphics and Modelling · doi:10.1016/j.jmgm.2006.02.009 · Cited by 475 · see citing works

Cholinergic and catecholaminergic receptors in the Xenopus oocyte membrane

Kusano, K., Miledi, R., & Stinnakre, J. (1982) · The Journal of Physiology · doi:10.1113/jphysiol.1982.sp014257 · Cited by 475 · see citing works

Scalable Molecular Dynamics with NAMD

Phillips, J. C., Schulten, K., Bhatele, A. S., Mei, C., Sun, Y., & Kalé, L. V. (2012) · University of North Texas Digital Library (University of North Texas) · Cited by 361 · see citing works

On the nature of allosteric transitions: Implications of non-exclusive ligand binding

Rubin, M. M., & Changeux, J. (1966) · Journal of Molecular Biology · doi:10.1016/0022-2836(66)90097-0 · Cited by 340 · see citing works

Ivermectin: A Positive Allosteric Effector of the α7 Neuronal Nicotinic Acetylcholine Receptor

Krause, R. M., Buisson, B., Bertrand, S., Corringer, P., Galzi, J., Changeux, J., & Bertrand, D. (1998) · Molecular Pharmacology · doi:10.1124/mol.53.2.283 · Cited by 320 · see citing works

A prokaryotic proton-gated ion channel from the nicotinic acetylcholine receptor family

Bocquet, N., de Carvalho, L. P., Cartaud, J., Neyton, J., Poupon, C. L., Taly, A., Grütter, T., Changeux, J., & Corringer, P. (2006) · Nature · doi:10.1038/nature05371 · Cited by 309 · see citing works

Identification of a GABA A Receptor Anesthetic Binding Site at Subunit Interfaces by Photolabeling with an Etomidate Analog

Li, G., Chiara, D. C., Sawyer, G. W., Husain, S. S., Olsen, R. W., & Cohen, J. B. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3467-06.2006 · Cited by 289 · see citing works

Oogenesis in Xenopus laevis (Daudin)

Holland, C., & Dumont, J. N. (1975) · Cell and Tissue Research · doi:10.1007/bf00209205 · Cited by 277 · see citing works

Allosteric modulation of nicotinic acetylcholine receptors

Bertrand, D., & Gopalakrishnan, M. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.07.011 · Cited by 256 · see citing works

Differential Sensitivities of Mammalian Neuronal and Muscle Nicotinic Acetylcholine Receptors to General Anesthetics

Violet, J. M., Downie, D. L., Nakisa, R. C., Lieb, W. R., & Franks, N. P. (1997) · Anesthesiology · doi:10.1097/00000542-199704000-00017 · Cited by 208 · see citing works

Differentiation of Cells of the Rana pipiens Gastrula in Unconditioned Medium1

BARTH, L. G., & Barth, L. J. (1959) · Development · doi:10.1242/dev.7.2.210 · Cited by 199 · see citing works

One-microsecond molecular dynamics simulation of channel gating in a nicotinic receptor homologue

Nury, H., Poitevin, F., Renterghem, C. V., Changeux, J., Corringer, P., Delarue, M. H., & Baaden, M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1001832107 · Cited by 157 · see citing works

An intramembrane aromatic network determines pentameric assembly of Cys-loop receptors

Haeger, S., Kuzmin, D., Detro‐Dassen, S., Lang, N., Kilb, M., Tsetlin, V. I., Betz, H., Laube, B., & Schmalzing, G. (2009) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1721 · Cited by 95 · see citing works

Anesthetic Sensitivity of the Gloeobacter violaceus Proton-Gated Ion Channel

Weng, Y., Yang, L., Corringer, P., & Sonner, J. M. (2009) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e3181c4bc69 · Cited by 94 · see citing works

Numerous Classes of General Anesthetics Inhibit Etomidate Binding to γ-Aminobutyric Acid Type A (GABAA) Receptors

Li, G., Chiara, D. C., Cohen, J. B., & Olsen, R. W. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.074708 · Cited by 82 · see citing works

A Unitary Anesthetic Binding Site at High Resolution

Vedula, L. S., Brannigan, G. H., Economou, N. J., Jin, X., Hall, M. A., Liu, R., Rossi, M. J., Dailey, W. P., Grasty, K. C., Klein, M. L., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.017814 · Cited by 78 · see citing works

Identification of Binding Sites in the Nicotinic Acetylcholine Receptor for [3H]Azietomidate, a Photoactivatable General Anesthetic

Ziebell, M. R., Nirthanan, S., Husain, S. S., Miller, K. W., & Cohen, J. B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313886200 · Cited by 77 · see citing works

Anionic Lipids Allosterically Modulate Multiple Nicotinic Acetylcholine Receptor Conformational Equilibria

daCosta, C. J. B., Medaglia, S. A., Lavigne, N., Wang, S., Carswell, C. L., & Baenziger, J. E. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.048280 · Cited by 68 · see citing works

GABA-Induced Intersubunit Conformational Movement in the GABA A Receptor α1M1-β2M3 Transmembrane Subunit Interface: Experimental Basis for Homology Modeling of an Intravenous Anesthetic Binding Site

Bali, M., Jansen, M., & Akabas, M. H. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.6090-08.2009 · Cited by 63 · see citing works

Comparative modeling of a GABAA alpha1 receptor using three crystal structures as templates

Trudell, J. R., & Bertaccini, E. J. (2004) · Journal of Molecular Graphics and Modelling · doi:10.1016/j.jmgm.2004.03.004 · Cited by 45 · see citing works

Modulation of Nicotinic Acetylcholine Receptor Conformational State by Free Fatty Acids and Steroids

Nievas, G. A. F., Barrantes, F. J., & Antollini, S. S. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800345200 · Cited by 43 · see citing works

Crystal structure of isoflurane bound to integrin LFA‐1 supports a unified mechanism of volatile anesthetic action in the immune and central nervous systems

Zhang, H., Astrof, N. S., Liu, J., Wang, J., & Shimaoka, M. (2009) · The FASEB Journal · doi:10.1096/fj.09-129908 · Cited by 41 · see citing works

Sites of alcohol and volatile anesthetic action on glycine receptors

Lobo, I. A., & Harris, R. A. (2005) · International Review of Neurobiology · doi:10.1016/s0074-7742(04)65003-3 · Cited by 40 · see citing works

Functional Complementation ofGlra1spd-ot, a Glycine Receptor Subunit Mutant, by Independently Expressed C-Terminal Domains

Villmann, C., Oertel, J., Ma‐Högemeier, Z., Hollmann, M., Sprengel, R., Becker, K., Breitinger, H., & Becker, C. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4400-08.2009 · Cited by 26 · see citing works

Experimental and theoretical approaches to conscious processing

Dehaene, S., & Changeux, J.-P. (2011) · Neuron · doi:10.1016/j.neuron.2011.03.018 · Cited by 2,573 · see citing works

Crystal structure of a human GABAA receptor

Miller, P. S., & Aricescu, A. R. (2014) · Nature · doi:10.1038/nature13293 · Cited by 713 · see citing works

Allostery and the Monod-Wyman-Changeux Model After 50 Years

Changeux, J. (2012) · Annual Review of Biophysics · doi:10.1146/annurev-biophys-050511-102222 · Cited by 393 · see citing works

Shared structural mechanisms of general anaesthetics and benzodiazepines

Kim, J. J., Gharpure, A., Teng, J., Zhuang, Y., Howard, R. J., Zhu, S., Noviello, C., Walsh, R. M., Lindahl, E. R., & Hibbs, R. E. (2020) · Nature · doi:10.1038/s41586-020-2654-5 · Cited by 382 · see citing works

GABAA receptor: Positive and negative allosteric modulators

Olsen, R. W. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.01.036 · Cited by 353 · see citing works

Allosteric Modulation as a Unifying Mechanism for Receptor Function and Regulation

Changeux, J., & Christopoulos, A. (2016) · Cell · doi:10.1016/j.cell.2016.08.015 · Cited by 341 · see citing works

Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist

Ahuja, S., Mukund, S., Deng, L., Khakh, K., Chang, E., Ho, H., Shriver, S., Young, C., Lin, S., Johnson, J. P., et al. (2015) · Science · doi:10.1126/science.aac5464 · Cited by 319 · see citing works

Pathophysiological and neurochemical mechanisms of postoperative nausea and vomiting

Horn, C. C., Wallisch, W. J., Homanics, G. E., & Williams, J. P. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.10.037 · Cited by 294 · see citing works

Multiscale Simulations of Biological Membranes: The Challenge To Understand Biological Phenomena in a Living Substance

Enkavi, G., Javanainen, M., Kulig, W., Róg, T., & Vattulainen, I. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00538 · Cited by 285 · see citing works

Interfacial inhibitors: targeting macromolecular complexes

Pommier, Y. G., & Marchand, C. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3404 · Cited by 260 · see citing works

Positive allosteric modulators as an approach to nicotinic acetylcholine receptor-targeted therapeutics: Advantages and limitations

Williams, D. K., Wang, J., & Papke, R. L. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.05.001 · Cited by 247 · see citing works

The CatSper channel: a polymodal chemosensor in human sperm

Brenker, C., Goodwin, N., Weyand, I., Kashikar, N. D., Naruse, M., Krähling, A. M., Müller, A., Kaupp, U. B., & Strünker, T. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.30 · Cited by 246 · see citing works

Towards a comprehensive understanding of anesthetic mechanisms of action: a decade of discovery

Hemmings, H. C., Riegelhaupt, P. M., Kelz, M. B., Solt, K., Eckenhoff, R. G., Orser, B. A., & Goldstein, P. A. (2019) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2019.05.001 · Cited by 244 · see citing works

International Union of Basic and Clinical Pharmacology. XC. Multisite Pharmacology: Recommendations for the Nomenclature of Receptor Allosterism and Allosteric Ligands

Christopoulos, A., Changeux, J., Catterall, W. A., Fabbro, D., Burris, T. P., Cidlowski, J. A., Olsen, R. W., Peters, J. A., Neubig, R. R., Pin, J., et al. (2014) · Pharmacological Reviews · doi:10.1124/pr.114.008862 · Cited by 238 · see citing works

Emerging Molecular Mechanisms of Signal Transduction in Pentameric Ligand-Gated Ion Channels

Nemecz, Á., Prevost, M. S., Menny, A., & Corringer, P. (2016) · Neuron · doi:10.1016/j.neuron.2016.03.032 · Cited by 238 · see citing works

Structure and Pharmacology of Pentameric Receptor Channels: From Bacteria to Brain

Corringer, P., Poitevin, F., Prevost, M. S., Sauguet, L., Delarue, M. H., & Changeux, J. (2012) · Structure · doi:10.1016/j.str.2012.05.003 · Cited by 237 · see citing works

The Nicotinic Acetylcholine Receptor: The Founding Father of the Pentameric Ligand-gated Ion Channel Superfamily

Changeux, J. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.r112.407668 · Cited by 235 · see citing works

A propofol binding site on mammalian GABAA receptors identified by photolabeling

Yip, G. M. S., Chen, Z.-W., Edge, C. J., Smith, E. H., Dickinson, R., Hohenester, E., Townsend, R. R., Fuchs, K., Sieghart, W., Evers, A. S., et al. (2013) · Nature Chemical Biology · doi:10.1038/nchembio.1340 · Cited by 226 · see citing works

Biological membranes: the importance of molecular detail

LEE, A. G. J. (2011) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2011.06.007 · Cited by 214 · see citing works

Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation

Sauguet, L., Shahsavar, A., Poitevin, F., Huon, C., Menny, A., Nemecz, Á., Haouz, A., Changeux, J., Corringer, P., & Delarue, M. H. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1314997111 · Cited by 202 · see citing works

Allosteric Modulation of GABAA Receptors via Multiple Drug-Binding Sites

Sieghart, W. (2014) · Advances in pharmacology · doi:10.1016/bs.apha.2014.10.002 · Cited by 198 · see citing works

Inhibitory Glycine Receptors: An Update

Dutertre, S., Becker, C., & Betz, H. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.r112.408229 · Cited by 194 · see citing works

Crystal structures of a GABAA-receptor chimera reveal new endogenous neurosteroid-binding sites.

Laverty, D., Thomas, P., Field, M., Andersen, O. J., Gold, M. G., Biggin, P. C., Gielen, M., & Smart, T. G. (2017) · Nature Structural &amp; Molecular Biology · doi:10.1038/nsmb.3477 · Cited by 179 · see citing works

50 years of allosteric interactions: the twists and turns of the models

Changeux, J. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3695 · Cited by 177 · see citing works

Sub-anesthetic concentrations of (R, S)-ketamine metabolites inhibit acetylcholine-evoked currents in α7 nicotinic acetylcholine receptors

Moaddel, R., Abdrakhmanova, G., Kozak, J., Jozwiak, K., Toll, L., Jimenez, L., Rosenberg, A., Tran, T., Xiao, Y., Zarate, C. A., et al. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.11.023 · Cited by 176 · see citing works

Understanding the Bases of Function and Modulation of α7 Nicotinic Receptors: Implications for Drug Discovery

Corradi, J., & Bouzat, C. (2016) · Molecular Pharmacology · doi:10.1124/mol.116.104240 · Cited by 168 · see citing works

Propofol: Milk of Amnesia

Walsh, C. T. (2018) · Cell · doi:10.1016/j.cell.2018.08.031 · Cited by 163 · see citing works

Ligand-Gated Ion Channels: New Insights into Neurological Disorders and Ligand Recognition

Lemoine, D., Jiang, R., Taly, A., Chataigneau, T., Specht, A., & Grütter, T. (2012) · Chemical Reviews · doi:10.1021/cr3000829 · Cited by 162 · see citing works

Lipid-Dependent Regulation of Ion Channels and G Protein–Coupled Receptors: Insights from Structures and Simulations

Duncan, A. L., Song, W., & Sansom, M. S. P. (2020) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010919-023411 · Cited by 158 · see citing works

Molecular Simulation Approaches to Membrane Proteins

Stansfeld, P. J., & Sansom, M. S. P. (2011) · Structure · doi:10.1016/j.str.2011.10.002 · Cited by 157 · see citing works

How drugs get into cells: tested and testable predictions to help discriminate between transporter-mediated uptake and lipoidal bilayer diffusion

Kell, D. B., & Oliver, S. G. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00231 · Cited by 155 · see citing works

The Biology of General Anesthesia from Paramecium to Primate

Kelz, M. B., & Mashour, G. A. (2019) · Current Biology · doi:10.1016/j.cub.2019.09.071 · Cited by 151 · see citing works

Evolution of Synapse Complexity and Diversity

Emes, R. D., & Grant, S. G. N. (2012) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-062111-150433 · Cited by 151 · see citing works

A gating mechanism of pentameric ligand-gated ion channels

Calimet, N., Simoes, M., Changeux, J.-P., Karplus, M., Taly, A., & Cecchini, M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1313785110 · Cited by 150 · see citing works

Structural basis for ion permeation mechanism in pentameric ligand‐gated ion channels

Sauguet, L., Poitevin, F., Murail, S., Renterghem, C. V., Moraga‐Cid, G., Malherbe, L., Thompson, A., Koehl, P., Corringer, P., Baaden, M., et al. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.17 · Cited by 147 · see citing works

Atomistic Simulations of Membrane Ion Channel Conduction, Gating, and Modulation

Flood, E., Boiteux, C., Lev, B. B., Vorobyov, I. V., & Allen, T. W. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00630 · Cited by 145 · see citing works

The promiscuous binding of pharmaceutical drugs and their transporter-mediated uptake into cells: what we (need to) know and how we can do so

Kell, D. B., Dobson, P. D., Bilsland, E., & Oliver, S. G. (2012) · Drug Discovery Today · doi:10.1016/j.drudis.2012.11.008 · Cited by 141 · see citing works

A locally closed conformation of a bacterial pentameric proton-gated ion channel

Prevost, M. S., Sauguet, L., Nury, H., Renterghem, C. V., Huon, C., Poitevin, F., Baaden, M., Delarue, M. H., & Corringer, P. (2012) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2307 · Cited by 140 · see citing works

The impact of human hyperekplexia mutations on glycine receptor structure and function

Bode, A., & Lynch, J. W. (2014) · Molecular Brain · doi:10.1186/1756-6606-7-2 · Cited by 136 · see citing works

Meta-diamide insecticides acting on distinct sites of RDL GABA receptor from those for conventional noncompetitive antagonists

Nakao, T., Banba, S., Nomura, M., & Hirase, K. (2013) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2013.02.002 · Cited by 135 · see citing works

Specificity of Intersubunit General Anesthetic-binding Sites in the Transmembrane Domain of the Human α1β3γ2 γ-Aminobutyric Acid Type A (GABAA) Receptor*

Chiara, D. C., Jayakar, S. S., Zhou, X., Zhang, X., Savechenkov, P. Y., Bruzik, K. S., Miller, K. W., & Cohen, J. B. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.479725 · Cited by 133 · see citing works

Structural basis for potentiation by alcohols and anaesthetics in a ligand-gated ion channel

Sauguet, L., Howard, R. J., Malherbe, L., Lee, U. S., Corringer, P., Harris, R. A., & Delarue, M. H. (2013) · Nature Communications · doi:10.1038/ncomms2682 · Cited by 132 · see citing works

The nicotinic acetylcholine receptor and its prokaryotic homologues: Structure, conformational transitions & allosteric modulation

Cecchini, M., & Changeux, J. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.12.006 · Cited by 128 · see citing works

Gating of Pentameric Ligand-Gated Ion Channels: Structural Insights and Ambiguities

daCosta, C. J. B., & Baenziger, J. E. (2013) · Structure · doi:10.1016/j.str.2013.06.019 · Cited by 120 · see citing works

The Concise Guide to PHARMACOLOGY 2013/14: Ligand‐Gated Ion Channels

Alexander, S. P. H., Benson, H. E., Faccenda, E., Pawson, A. J., Sharman, J. L., Spedding, M., Peters, J. A., Harmar, A. J., & Collaborators, C. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12446 · Cited by 120 · see citing works

Molecular dynamics simulations of the interactions of medicinal plant extracts and drugs with lipid bilayer membranes

Kopeć, W., Telenius, J. M., & Khandelia, H. (2013) · FEBS Journal · doi:10.1111/febs.12286 · Cited by 118 · see citing works

Ligand binding at the protein–lipid interface: strategic considerations for drug design

Payandeh, J., & Volgraf, M. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00240-2 · Cited by 118 · see citing works

Multiple Propofol-binding Sites in a γ-Aminobutyric Acid Type A Receptor (GABAAR) Identified Using a Photoreactive Propofol Analog

Jayakar, S. S., Zhou, X., Chiara, D. C., Dostalova, Z., Savechenkov, P. Y., Bruzik, K. S., Dailey, W. P., Miller, K. W., Eckenhoff, R. G., & Cohen, J. B. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.581728 · Cited by 116 · see citing works

γ-Aminobutyrate- and Glutamate-gated Chloride Channels as Targets of Insecticides

Ozoe, Y. (2013) · Advances in insect physiology · doi:10.1016/b978-0-12-394389-7.00004-1 · Cited by 115 · see citing works

Liquid General Anesthetics Lower Critical Temperatures in Plasma Membrane Vesicles

Gray, E. J., Karslake, J. D., Machta, B. B., & Veatch, S. L. (2013) · Biophysical Journal · doi:10.1016/j.bpj.2013.11.005 · Cited by 111 · see citing works

Molecular blueprint of allosteric binding sites in a homologue of the agonist-binding domain of the α7 nicotinic acetylcholine receptor

Spurný, R., Debaveye, S., Farinha, A., Veys, K., Vos, A. M., Gossas, T., Atack, J. R., Bertrand, S., Bertrand, D., Danielson, U. H., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1418289112 · Cited by 109 · see citing works

Mapping General Anesthetic Binding Site(s) in Human α1β3 γ-Aminobutyric Acid Type A Receptors with [3H]TDBzl-Etomidate, a Photoreactive Etomidate Analogue

Chiara, D. C., Dostalova, Z., Jayakar, S. S., Zhou, X., Miller, K. W., & Cohen, J. B. (2012) · Biochemistry · doi:10.1021/bi201772m · Cited by 107 · see citing works

Structural basis for alcohol modulation of a pentameric ligand-gated ion channel

Howard, R. J., Murail, S., Ondricek, K. E., Corringer, P., Lindahl, E. R., Trudell, J. R., & Harris, R. A. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1104480108 · Cited by 106 · see citing works

Allosteric modulation of glycine receptors

Yévenes, G. E., & Zeilhofer, H. U. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01471.x · Cited by 105 · see citing works

Allosteric modulation of nicotinic acetylcholine receptors

Chatzidaki, A., & Millar, N. S. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2015.07.028 · Cited by 104 · see citing works

Anesthetic sites and allosteric mechanisms of action on Cys-loop ligand-gated ion channels

Forman, S. A., & Miller, K. W. (2011) · Canadian Journal of Anesthesia/Journal canadien d anesthésie · doi:10.1007/s12630-010-9419-9 · Cited by 103 · see citing works

Multiple functional neurosteroid binding sites on GABAA receptors

Chen, Z.-W., Bracamontes, J. R., Budelier, M. M., Germann, A. L., Shin, D. J., Krishnan, K., Qian, M., Manion, B. D., Cheng, W. W. L., Reichert, D. E. C., et al. (2019) · PLoS Biology · doi:10.1371/journal.pbio.3000157 · Cited by 99 · see citing works

The Primitive Thylakoid-Less Cyanobacterium Gloeobacter Is a Common Rock-Dwelling Organism

Mareš, J., Hrouzek, P., Kaňa, R., Ventura, S., Strunecký, O., & Komárek, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066323 · Cited by 98 · see citing works

The nicotinic acetylcholine receptor: a typical ‘allosteric machine’

Changeux, J. (2018) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2017.0174 · Cited by 96 · see citing works

GABAA receptor modulation by terpenoids from Sideritis extracts

Kessler, A., Nadeem, H. Ş., Lummis, S. C. R., Weigel, I., Pischetsrieder, M., Buettner, A., & Villmann, C. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201300420 · Cited by 96 · see citing works

A novel GABAAreceptor pharmacology: drugs interacting with the α+β‐interface

Sieghart, W., Ramerstorfer, J., Sarto‐Jackson, I., Varagić, Z., & Ernst, M. C. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01779.x · Cited by 95 · see citing works

Mechanism of action of the insecticides, lindane and fipronil, on glycine receptor chloride channels

Islam, R., & Lynch, J. W. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01722.x · Cited by 94 · see citing works

Multisite Binding of a General Anesthetic to the Prokaryotic Pentameric Erwinia chrysanthemi Ligand-gated Ion Channel (ELIC)

Spurný, R., Billen, B., Howard, R. J., Brams, M., Debaveye, S., Price, K. L., Weston, D. A., Strelkov, S. V., Tytgat, J., Bertrand, S., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.424507 · Cited by 92 · see citing works

Structural Studies of GABAA Receptor Binding Sites: Which Experimental Structure Tells us What?

Puthenkalam, R., Hieckel, M., Simeone, X., Suwattanasophon, C., Feldbauer, R., Ecker, G. F., & Ernst, M. C. (2016) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2016.00044 · Cited by 90 · see citing works

Rational design of allosteric modulators: Challenges and successes

Chatzigoulas, A., & Cournia, Z. (2021) · Wiley Interdisciplinary Reviews Computational Molecular Science · doi:10.1002/wcms.1529 · Cited by 87 · see citing works

Inhibition of K-RAS4B by a Unique Mechanism of Action: Stabilizing Membrane-Dependent Occlusion of the Effector-Binding Site

Fang, Z., Marshall, C. B., Nishikawa, T., Gossert, A. D., Jansen, J. M., Jahnke, W., & Ikura, M. (2018) · Cell Chemical Biology · doi:10.1016/j.chembiol.2018.07.009 · Cited by 86 · see citing works

The concept of allosteric modulation: an overview

Changeux, J. (2012) · Drug Discovery Today Technologies · doi:10.1016/j.ddtec.2012.07.007 · Cited by 86 · see citing works

Mutations that stabilize the open state of the Erwinia chrisanthemi ligand-gated ion channel fail to change the conformation of the pore domain in crystals

González-Gutiérrez, G., Lukk, T., Agarwal, V., Papke, D. J., Nair, S. K., & Grosman, C. F. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1119268109 · Cited by 85 · see citing works

A Predicted Binding Site for Cholesterol on the GABAA Receptor

Hénin, J., Salari, R., Murlidaran, S., & Brannigan, G. H. (2014) · Biophysical Journal · doi:10.1016/j.bpj.2014.03.024 · Cited by 84 · see citing works

Structure and pharmacologic modulation of inhibitory glycine receptors

Burgos, C. F., Yévenes, G. E., & Aguayo, L. G. (2016) · Molecular Pharmacology · doi:10.1124/mol.116.105726 · Cited by 83 · see citing works

Functional prokaryotic–eukaryotic chimera from the pentameric ligand-gated ion channel family

Duret, G., Renterghem, C. V., Weng, Y., Prevost, M. S., Moraga‐Cid, G., Huon, C., Sonner, J. M., & Corringer, P. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1104494108 · Cited by 82 · see citing works

Structure of the Pentameric Ligand-Gated Ion Channel GLIC Bound with Anesthetic Ketamine

Pan, J., Chen, Q., Willenbring, D., Mowrey, D. D., Kong, X., Cohen, A. E., Divito, C. B., Xu, Y., & Tang, P. S. (2012) · Structure · doi:10.1016/j.str.2012.08.009 · Cited by 81 · see citing works

Molecular Mechanisms of Drug Action: An Emerging View

Sonner, J. M., & Cantor, R. S. (2013) · Annual Review of Biophysics · doi:10.1146/annurev-biophys-083012-130341 · Cited by 79 · see citing works

String method solution of the gating pathways for a pentameric ligand-gated ion channel

Lev, B. B., Murail, S., Poitevin, F., Cromer, B. A., Baaden, M., Delarue, M. H., & Allen, T. W. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1617567114 · Cited by 78 · see citing works

G protein coupled receptor interactions with cholesterol deep in the membrane

Genheden, S., Essex, J. W., & LEE, A. G. J. (2016) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2016.12.001 · Cited by 74 · see citing works

Identification of Propofol Binding Sites in a Nicotinic Acetylcholine Receptor with a Photoreactive Propofol Analog*

Jayakar, S. S., Dailey, W. P., Eckenhoff, R. G., & Cohen, J. B. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.435909 · Cited by 72 · see citing works

Mapping General Anesthetic Sites in Heteromeric γ-Aminobutyric Acid Type A Receptors Reveals a Potential For Targeting Receptor Subtypes

Forman, S. A., & Miller, K. W. (2016) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000001368 · Cited by 72 · see citing works

Theory and Simulation of Ion Conduction in the Pentameric GLIC Channel

Zhu, F., & Hummer, G. (2012) · Journal of Chemical Theory and Computation · doi:10.1021/ct2009279 · Cited by 71 · see citing works

Functional anatomy of an allosteric protein

Purohit, P. G., Gupta, S., Jadey, S. V., & Auerbach, A. L. (2013) · Nature Communications · doi:10.1038/ncomms3984 · Cited by 71 · see citing works

Single-Channel and Structural Foundations of Neuronal α7 Acetylcholine Receptor Potentiation

daCosta, C. J. B., Free, C. R., Corradi, J., Bouzat, C., & Sine, S. M. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.2652-11.2011 · Cited by 70 · see citing works

Shaker-related potassium channels in the central medial nucleus of the thalamus are important molecular targets for arousal suppression by volatile general anesthetics

Lioudyno, M. I., Birch, A. M., Tanaka, B. S., Sokolov, Y., Goldin, A. L., Chandy, K. G., Hall, J. E., & Alkire, M. T. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.0344-13.2013 · Cited by 68 · see citing works

The Glycine Receptor—A Functionally Important Primary Brain Target of Ethanol

Söderpalm, B., Lidö, H. H., & Ericson, M. (2017) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13483 · Cited by 68 · see citing works

GABA allosteric modulators: An overview of recent developments in non-benzodiazepine modulators

Solomon, V. R., Tallapragada, V. J., Chebib, M., Johnston, G. A. R., & Hanrahan, J. R. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.03.043 · Cited by 68 · see citing works

Crystal structure and dynamics of a lipid-induced potential desensitized-state of a pentameric ligand-gated channel

Basak, S., Schmandt, N., Gicheru, Y. W., & Chakrapani, S. (2017) · eLife · doi:10.7554/elife.23886 · Cited by 67 · see citing works

Structural mechanisms of activation and desensitization in neurotransmitter-gated ion channels

Plested, A. J. R. (2016) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.3214 · Cited by 66 · see citing works

Binding of Serotonin to Lipid Membranes

Peters, G. H. J., Wang, C., Cruys‐Bagger, N., Velardez, G. F., Madsen, J. J., & Westh, P. (2013) · Journal of the American Chemical Society · doi:10.1021/ja306681d · Cited by 65 · see citing works

Nicotinic acetylcholine receptor–lipid interactions: Mechanistic insight and biological function

Baenziger, J. E., Hénault, C. M., Therien, J. P. D., & Sun, J. (2015) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2015.03.010 · Cited by 65 · see citing works

HCN1 Channels as Targets for Anesthetic and Nonanesthetic Propofol Analogs in the Amelioration of Mechanical and Thermal Hyperalgesia in a Mouse Model of Neuropathic Pain

Tibbs, G. R., Rowley, T. J., Sanford, R. L., Herold, K. F., Proekt, A., Hemmings, H. C., Andersen, O. S., Goldstein, P. A., & Flood, P. D. (2013) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.113.203620 · Cited by 65 · see citing works

Desensitization Mechanism in Prokaryotic Ligand-gated Ion Channel

Velisetty, P., & Chakrapani, S. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.348045 · Cited by 64 · see citing works

GABA Binding to an Insect GABA Receptor: A Molecular Dynamics and Mutagenesis Study

Ashby, J., McGonigle, I., Price, K. L., Cohen, N., Comitani, F., Dougherty, D. A., Molteni, C., & Lummis, S. C. R. (2012) · Biophysical Journal · doi:10.1016/j.bpj.2012.10.016 · Cited by 64 · see citing works

Mechanistic Understanding from Molecular Dynamics in Pharmaceutical Research 2: Lipid Membrane in Drug Design

Róg, T., Girych, M., & Bunker, A. (2021) · Pharmaceuticals · doi:10.3390/ph14101062 · Cited by 63 · see citing works

General Anesthetics Predicted to Block the GLIC Pore with Micromolar Affinity

LeBard, D. N., Hénin, J., Eckenhoff, R. G., Klein, M. L., & Brannigan, G. H. (2012) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002532 · Cited by 63 · see citing works

Crystallographic studies of pharmacological sites in pentameric ligand-gated ion channels

Sauguet, L., Shahsavar, A., & Delarue, M. H. (2014) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2014.05.007 · Cited by 62 · see citing works

Structural Models of Ligand‐Gated Ion Channels: Sites of Action for Anesthetics and Ethanol

Olsen, R. W., Li, G., Wallner, M., Trudell, J. R., Bertaccini, E. J., Lindahl, E. R., Miller, K. W., Alkana, R. L., & Davies, D. L. (2013) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12283 · Cited by 61 · see citing works

Functional Annotation of Ion Channel Structures by Molecular Simulation

Trick, J. L., Chelvaniththilan, S., Klesse, G., Aryal, P., Wallace, E. J., Tucker, S. J., & Sansom, M. S. P. (2016) · Structure · doi:10.1016/j.str.2016.10.005 · Cited by 61 · see citing works

A lipid site shapes the agonist response of a pentameric ligand-gated ion channel

Hénault, C. M., Govaerts, C., Spurný, R., Brams, M., Estrada‐Mondragón, A., Lynch, J. W., Bertrand, D., Pardon, E., Evans, G. L., Woods, K., et al. (2019) · Nature Chemical Biology · doi:10.1038/s41589-019-0369-4 · Cited by 61 · see citing works

Do Nicotinic Receptors Modulate High-Order Cognitive Processing?

Koukouli, F., & Changeux, J. (2020) · Trends in Neurosciences · doi:10.1016/j.tins.2020.06.001 · Cited by 61 · see citing works

Multiple targets for flecainide action: implications for cardiac arrhythmogenesis

Salvage, S. C., Chandrasekharan, K. H., Jeevaratnam, K., Dulhunty, A. F., Thompson, A. J., Jackson, A. P., & Huang, C. L.-H. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13807 · Cited by 60 · see citing works

Structure–Function Relationships of Glycine and GABAA Receptors and Their Interplay With the Scaffolding Protein Gephyrin

Kasaragod, V. B., & Schindelin, H. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00317 · Cited by 60 · see citing works

Seeking structural specificity: direct modulation of pentameric ligand-gated ion channels by alcohols and general anesthetics

Howard, R. J., Trudell, J. R., & Harris, R. A. (2014) · Pharmacological Reviews · doi:10.1124/pr.113.007468 · Cited by 56 · see citing works

Allosteric Transition and Pharmacological Modulation of Pentameric Channel-Receptors: The Case of General Anesthetics

Corringer, P., Nury, H., Renterghem, C. V., Yeng, Y., Tran, A., Baaden, M., Changeux, J., Sonner, J. M., & Delarue, M. H. (2012) · Biophysical Journal · doi:10.1016/j.bpj.2011.11.060

Study of the Interaction Between General Anesthetics and a Bacterial Homologue to the Human Nicotinic Receptor

Laurent, B., Baaden, M., Delarue, M. H., & Corringer, P. (2012) · Biophysical Journal · doi:10.1016/j.bpj.2011.11.640

X-Ray Crystallographic Studies for Revealing Binding Sites of General Anesthetics in Pentameric Ligand-Gated Ion Channels

Chen, Q., Xu, Y., & Tang, P. S. (2018) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2018.01.017 · Cited by 2 · see citing works

The allosteric regulation of general anesthetics on protein models and ion channels as well as their target sites

Gao, S. (2014) · Guoji mazuixue yu fusu zazhi · doi:10.3760/cma.j.issn.1673-4378.2014.01.019

Structural Basis for a Bimodal Allosteric Mechanism of General Anesthetic Modulation in Pentameric Ligand-Gated Ion Channels

Fourati, Z., Howard, R. J., Heusser, S. A., Hu, H., Ruza, R. R., Sauguet, L., Lindahl, E. R., & Delarue, M. H. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.03.108 · Cited by 34 · see citing works