Franks, Nicholas P.

General anaesthesia: from molecular targets to neuronal pathways of sleep and arousal

Franks, N. P. (2008) · Nature Reviews Neuroscience

Anesthesia and Sedative AgentsAnesthesia and Neurotoxicity Research

Cited by 1,295

The α2-Adrenoceptor Agonist Dexmedetomidine Converges on an Endogenous Sleep-promoting Pathway to Exert Its Sedative Effects

Nelson, L. E., Lu, J., Guo, T., Saper, C. B., Franks, N. P., & Maze, M. (2003) · Anesthesiology

Sleep and Wakefulness ResearchAnesthesia and Sedative Agents

Cited by 854

Do general anaesthetics act by competitive binding to specific receptors?

Franks, N. P., & Lieb, W. R. (1984) · Nature

Anesthesia and Sedative AgentsAnesthesia and Neurotoxicity Research

Cited by 572

The sedative component of anesthesia is mediated by GABAA receptors in an endogenous sleep pathway

Nelson, L. E., Guo, T. Z., Lu, J., Saper, C. B., Franks, N. P., & Maze, M. (2002) · Nature Neuroscience

Anesthesia and Sedative AgentsSleep and Wakefulness Research

Cited by 568

Neuronal ensembles sufficient for recovery sleep and the sedative actions of α2 adrenergic agonists

Zhang, Z., Ferretti, V., Güntan, İ., Moro, A., Steinberg, E. A., Ye, Z., Zecharia, A. Y., Yu, X., Vyssotski, A. L., Brickley, S. G., et al. (2015) · Nature Neuroscience

Sleep and Wakefulness ResearchNeuroscience of respiration and sleep

Cited by 275

The Temperature Dependence of Sleep

Harding, E. C., Franks, N. P., & Wisden, W. (2019) · Frontiers in Neuroscience

Sleep and Wakefulness ResearchCircadian rhythm and melatonin

Cited by 261

A propofol binding site on mammalian GABAA receptors identified by photolabeling

Yip, G. M. S., Chen, Z.-W., Edge, C. J., Smith, E. H., Dickinson, R., Hohenester, E., Townsend, R. R., Fuchs, K., Sieghart, W., Evers, A. S., et al. (2013) · Nature Chemical Biology

Neuroscience and Neuropharmacology ResearchAnesthesia and Sedative Agents

Cited by 226

Moderate hypothermia within 6 h of birth plus inhaled xenon versus moderate hypothermia alone after birth asphyxia (TOBY-Xe): a proof-of-concept, open-label, randomised controlled trial

Azzopardi, D., Robertson, N. J., Bainbridge, A., Cady, E., Charles-Edwards, G., Deierl, A., Fagiolo, G., Franks, N. P., Griffiths, J., Hajnal, J., et al. (2016) · The Lancet Neurology

Neonatal and fetal brain pathologyThermal Regulation in Medicine

Cited by 220

The TREK K2P channels and their role in general anaesthesia and neuroprotection

Franks, N. P., & Honoré, E. (2004) · Trends in Pharmacological Sciences

Ion channel regulation and functionAnesthesia and Sedative Agents

Cited by 214

Volatile general anaesthetics activate a novel neuronal K+ current

Franks, N. P., & Lieb, W. R. (1988) · Nature

Ion channel regulation and functionAnesthesia and Sedative Agents

Cited by 199

Brain clearance is reduced during sleep and anesthesia

Miao, A., Luo, T., Hsieh, B., Edge, C. J., Gridley, M., Wong, R. T. C., Constandinou, T. G., Wisden, W., & Franks, N. P. (2024) · Nature Neuroscience

Cerebrospinal fluid and hydrocephalusSleep and Wakefulness Research

Cited by 172

A neuronal hub binding sleep initiation and body cooling in response to a warm external stimulus

Harding, E. C., Yu, X., Miao, A., Andrews, N., Ma, Y., Ye, Z., Lignos, L., Miracca, G., Ba, W., Yustos, R., et al. (2018) · Current Biology

Sleep and Wakefulness ResearchNeuroscience of respiration and sleep

Cited by 136

Excitatory pathways from the lateral habenula enable propofol-induced sedation

Gelegen, C., Miracca, G., Ran, M. Z., Harding, E. C., Ye, Z., Yu, X., Tossell, K., Houston, C. M., Yustos, R., Hawkins, E. D., et al. (2018) · Current Biology

Sleep and Wakefulness ResearchAnesthesia and Sedative Agents

Cited by 100

An unexpected role for TASK-3 potassium channels in network oscillations with implications for sleep mechanisms and anesthetic action

Pang, D. S. J., Robledo, C. J., Carr, D. R., Gent, T. C., Vyssotski, A. L., Caley, A., Zecharia, A. Y., Wisden, W., Brickley, S. G., & Franks, N. P. (2009) · Proceedings of the National Academy of Sciences

Ion channel regulation and functionNeural dynamics and brain function

Cited by 97

The inescapable drive to sleep: Overlapping mechanisms of sleep and sedation

Franks, N. P., & Wisden, W. (2021) · Science

Sleep and Wakefulness ResearchSleep and Work-Related Fatigue

Cited by 74

Determinants of the Anesthetic Sensitivity of Two-pore Domain Acid-sensitive Potassium Channels

Andres-Enguix, I., Caley, A., Yustos, R., Schumacher, M. A., Spanu, P. D., Dickinson, R., Maze, M., & Franks, N. P. (2007) · Journal of Biological Chemistry

Ion channel regulation and functionAnesthesia and Sedative Agents

Cited by 52

Bottom-Up versus Top-Down Induction of Sleep by Zolpidem Acting on Histaminergic and Neocortex Neurons

Uygun, D. S., Ye, Z., Zecharia, A. Y., Harding, E. C., Yu, X., Yustos, R., Vyssotski, A. L., Brickley, S. G., Franks, N. P., & Wisden, W. (2016) · The Journal of Neuroscience

Sleep and Wakefulness ResearchNeuroscience and Neuropharmacology Research

Cited by 48