The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
New classes of self-cleaving ribozymes revealed by comparative genomics analysis
Open accessAbstract
Enzymes made of RNA catalyze reactions that are essential for protein synthesis and RNA processing. However, such natural ribozymes are exceedingly rare, as evident by the fact that the discovery rate for new classes has dropped to one per decade from about one per year during the 1980s. Indeed, only 11 distinct ribozyme classes have been experimentally validated to date. Recently, we recognized that self-cleaving ribozymes frequently associate with certain types of genes from bacteria. Herein this synteny was exploited to identify divergent architectures for two previously known ribozyme classes and to discover additional noncoding RNA motifs that are self-cleaving RNA candidates. Three new self-cleaving classes, named twister sister, pistol and hatchet, have been identified from this collection, suggesting that even more ribozymes remain hidden in modern cells.
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Cites
A framework for human microbiome research
The Human Microbiome Project Consortium (2012) · Nature · doi:10.1038/nature11209 · Cited by 2,650
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In vitro evolution suggests multiple origins for the hammerhead ribozyme
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Comprehensive datasets for RNA design, machine learning, and beyond
Badura, J., Rybarczyk, A., & Zok, T. (2025) · Scientific Reports · doi:10.1038/s41598-025-07041-2 · Cited by 3
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Wang, S., Wang, J., Liu, X., Zhu, W., Huang, J., Xue, Y., Yan, J., Shen, H.-B., Song, J., & Pan, X. (2026) · Nature Computational Science · doi:10.1038/s43588-026-01029-2 · Cited by 2
Metadata
- Authors
- Weinberg, Z., Kim, P. B., Chen, T. H., Li, S., Harris, K. A., Lünse, C. E., & Breaker, R. R.
- Venue
- Nature Chemical Biology
- Published
- 2015-07-13
- Volume
- 11
- Issue
- 8
- Pages
- 606-610
- ISSN
- 1552-4450 (ISSN-L)
- 1552-4469
- OpenAlex
- W1585990551
- Cited by
- 227
- References
- 4
- FWCI
- 10.04
- Type
- journal article
- Language
- en
- Open access
- green
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