Thermal profiling reveals phenylalanine hydroxylase as an off-target of panobinostat
Becher, Isabelle, Werner, Thilo, Doce, Carola, Zaal, Esther A, Tögel, Ina, Khan, Crystal A, Rueger, Anne, Muelbaier, Marcel, Salzer, Elsa, Berkers, Celia R, Fitzpatrick, Paul F, Bantscheff, Marcus, Savitski, Mikhail M·2016·Nature Chemical Biology
Cited by (254)
Items 201–254 of 254
- Identification of the binding proteins of organic acid metabolites by matrix thermal shift assayKejia Li, Yu‐Ying Ye, Xiaolei Zhang, Jiahua Zhou, Ya-Nan Li, Mingliang Ye · 2024 · Chinese Journal of Chromatography
- Targeted PPARδ activation reprograms microglial immunometabolism and improves insulin sensitivity in HFD-fed ratsHan Jiao, Fernando Cázarez‐Márquez, Valentina Sophia Rumanova, Yalin Wang, Andries Kalsbeek, Gertjan Kramer, Shanshan Guo, Chun‐Xia Yi · 2026 · Journal of Lipid Research
- Biophysical Sensing Tools in Drug Discovery: Integrating Kinetics, Thermodynamics, Cellular Target Engagement and StructureEsra Balıkçı, Caner Akıl · 2026 · Sensors
- Bufalin inhibits proliferation of non-small cell lung cancer by promoting metabolic reprogramming through inhibition of pyruvate kinase M2Boyu Li, Ziwei Han, Jinghui Zhang, Tiantian Meng, Yingshuai Zheng, Yuting Guan, Liyan Qian, Yijuan Chen, Xuesong Liu, Lutfun Nahar et al. · 2026 · Biochemical Pharmacology
- An Overview of Panobinostat: Pharmacological and Medicinal Chemistry AspectsAjam Chand Shaikh, Swastika Banerjee, Vijay Bahadur, Pravin R. Bhansali · 2026 · Chemical Biology & Drug Design
- Reduning injection alleviated LPS-induced ARDS via multi-target regulation by modulating inflammation and immune responses based on target fishing technique and scRNA-seq analysisSi-Wen Hui, Qi-Meng Zhu, Zi-zhou Liu, Xin-Rong Xu, Huilin Zhang, Jing Chang, Ya-Xue Jia, Feng Qiu, Shan-Shan Guo, Juan Zhang et al. · 2026 · Phytomedicine
- Identifying drug targets with thermal proteome profiling using IBT‐16plexZhaomei Shi, Yan Ren, Shuwei Li, Piliang Hao · 2023 · Rapid Communications in Mass Spectrometry
- Robust approach for production of the human oncology target Aurora kinase B in complex with its binding partner INCENPJonna Mattsson, Per Rogne, Maréne Landström, Magnus Wolf‐Watz · 2024 · Biochimie
- Phenotype-Led Identification of IL-10 Upregulators in Human CD4+ T-cells and Elucidation of Their Pharmacology as Highly Selective CDK8/CDK19 InhibitorsSimon Nicolle, Mike D. Barker, John Barrett, Matthew J. Campbell, Justyna Wojno, Stephen J. Atkinson, Helen E. Aylott, Hripsimée Kessedjian, Yanan He, Cassie Messenger et al. · 2025 · Journal of Medicinal Chemistry
- In silico screening of a designed focused chemical space identifies novel alkyl hydrazides as potent HDAC11 inhibitorsFady Baselious, Sebastian Hilscher, Lukas Handke, Cyril Bařinka, Mike Schutkowski, Wolfgang Sippl · 2025 · Computers in Biology and Medicine
- Proteome-scale studies of protein stabilityGiulia Calloni, R. Martin Vabulas · 2020 · Elsevier eBooks
- Assays to Characterize the Cellular Pharmacology of a Chemical ProbeJakub Stefaniak, Sébastien R. G. Galan, K. Huber · 2020 · Royal Society of Chemistry eBooks
- Marine Natural Products and ObesityRalph Urbatzka, Vitor Manuel Vasconcelos · 2019 · MDPI eBooks
- Label‐Free Techniques for Target Discovery and ValidationDaniel Martinez Molina, Michael A. Dabrowski · 2019 · Methods and principles in medicinal chemistry
- A chemical biology toolbox to investigate in-cell target engagement and specificity of PRMT5-inhibitorsElisabeth M. Rothweiler, Jakub Stefaniak, Jennifer Ward, Catherine M. Rogers, Esra Balıkçı, K. Huber · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
- Thermal Proteome Profiling reveals rapid proteomic responses to redox changes in specific cellular compartmentsAram Revazian, Alexey M. Nesterenko, Daria Ezeriņa, Ting Luo, Didier Vertommen, Christine Silvia Gibhardt, Ivan Bogeski, Joris Messens, Vsevolod Vadimovich Belousov · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- Targeted activation of microglial PPARδ reprograms immunometabolism and enhances insulin sensitivity in diet-induced obesityHan Jiao, Fernando Cázarez‐Márquez, Shanshan Guo, Andries Kalsbeek, Gertjan Krammer, Chun‐Xia Yi · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- MALDI-TOF mass spectrometry and proteomics as phenotypic screening tools for anti-inflammatory drugsLeonie Müller, Serena Bateman, Charlie Haslam, Thomas K. Dawson, Denise F. Vlachou, Evan Rosa-Roseberry, Lee M. Booty, Chloe L. Tayler, Andrew Michael Frey, Roland S. Annan et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- The cellular thermal shift assay : a novel strategy to study drug target engagement and resistance development in cancer therapyUsha Sreekumar Lekshmy Kunjamma · 2018
- Molecular analysis of antimalarial therapies : from drug development to mode of actionJerzy Michal Dziekan · 2018
- Advanced Assays in EpigeneticsCarmela Dell’Aversana, Federica Sarno, Mariarosaria Conte, Cristina Di Giorgio, Lucia Altucci · 2019 · Topics in medicinal chemistry
- A New Drug Discovery Approach Based on Thermal Proteome Profiling to Develop More Effective DrugsElham Gholizadeh, Mostafa Rezaei–Tavirani, Alireza Emadi, Reza Karbalaei, Ali Khaleghian · 2021 · Middle East Journal of Rehabilitation and Health Studies
- Advancing antiviral strategies against emerging RNA viruses by phenotypic drug discoveryMarianna Tampere · 2021 · Figshare
- Diving into cellular signallingNiels M. Leijten · 2021 · Utrecht University Repository (Utrecht University)
- Faculty Opinions recommendation of A new antibiotic selectively kills Gram-negative pathogens.Vincent Cattoir · 2020 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Faculty Opinions recommendation of A Dual-Mechanism Antibiotic Kills Gram-Negative Bacteria and Avoids Drug Resistance.Wenjun Zhang, Zhijuan Hu · 2020 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Faculty Opinions recommendation of A new antibiotic selectively kills Gram-negative pathogens.Jens‐Michael Schröder · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Faculty Opinions recommendation of Proteome-wide solubility and thermal stability profiling reveals distinct regulatory roles for ATP.Kausik Chakraborty · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- The discovery of antibiotics from soil and the characterization of darobactin analogsRobert Green · 2022 · Digital Repository Service (Northeastern University)
- Cellular response to compartmentalized redox alterationsAram Revazian · 2022 · eDiss (Georg-August-Universität Göttingen)
- Improved in situ Characterization of Proteome-wide Protein Complex Dynamics with Thermal Proximity Co-AggregationSiyuan Sun, Zhenxiang Zheng, Jun Wang, Fengming Li, An He, Ruijun Tian, Chris Soon Heng Tan · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- Dextromethorphan inhibits collagen transport in the endoplasmic reticulum eliciting an anti-fibrotic response in ex-vivo and in vitro models of pulmonary fibrosisMuzamil Majid Khan, Joanna Zukowska, Juan E. Jung, George Galea, Nadine Tuechler, Aliaksandr A. Halavatyi, Christian Tischer, Per Haberkant, Frank Stein, Ferris Jung et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- Fully automated and integrated proteomics sample preparation platform for high-throughput drug target identificationQiong Di Wu, Jiangnan Zheng, Xintong Sui, Changying Fu, Xiaozhen Cui, Bin Yih Liao, Hongchao Ji, Yang Luo, An He, Xue Mei Lu et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- Integration of Thermal Proteome Profiling with phosphoproteomic and transcriptomic data via mechanistic network models decodes the molecular response to PARP inhibitionMira Lea Burtscher, Stephan Gade, Martín Garrido‐Rodríguez, Ania Rutkowska, Thilo Werner, H. Christian Eberl, Massimo Petretich, Natascha Knopf, Katharina Zirngibl, Paola Grandi et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- Development and evaluation of data analysis approaches to increase the specificity and performance of thermal shift assays for assessment of protein-small molecule interactionsAmanda M. Figueroa‐Navedo · 2023
- Development of improved drug-target profiling methods using mass spectrometry-based thermal stability assaysClifford G. Phaneuf · 2023
- TargetSeeker-MS: A Bayesian Inference Approach for Drug–Target Discovery Using Protein Fractionation Coupled to Mass SpectrometryMathieu Lavallée‐Adam, Alexander R. Pelletier, Jolene K. Diedrich, Antônio F. M. Pinto, Salvador Martínez‐Bartolomé, Michael Petrascheck, James J. Moresco, John R. Yates · 2025 · Journal of the American Society for Mass Spectrometry
- Advances in Drug Discovery: Navigating Challenges and Embracing InnovationKamila Khikhmetova · 2025 · Australian Journal of Biomedical Research
- Proteome-Wide Monitoring of Drug Action in Living Cells Using a Novel Label-Free Solvent-Based Shift AssayDominik Steinbrunn, Catalina Cepeleaga, Alexander Betz, Gözde Kibar, Melanie Holzner, Stefan K. Maier, Christin Zasada, Götz Hagemann, Stephan A. Sieber, Hannes Hahne · 2025 · Molecular & Cellular Proteomics
- ThermoESM: Bridging Experimental Tm and OGT Data with Protein Language Model for Reliable Protein Thermal Stability ClassificationJian Zhang, Yang Liu, Minghui Li · 2025 · Journal of Computational Biophysics and Chemistry
- DrPISA: Deep eutectic solvent-assisted reverse proteome-integrated solubility alteration for high-sensitivity drug target identificationLiu Yang, Tian-Bo Ma, Chen-Wan Guo, Run-Bo Yu, Ping Li, Hua Yang, Wen Gao · 2026 · Analytica Chimica Acta
- A Covalent Targeted Platform for Protein Dynamic TrackingBochao Chen, Yong Cheng, Zairong Men, Wei Zhang, Jing-Jing Hu, Fan Xia, Xiaoding Lou · 2026 · Analytical Chemistry
- Therapeutic targeting of SETD2-deficient cancer cells with the small-molecule compound RITATimothy C. Humphrey, Kirsten Anne Pagaduan Lopez, Deborah Sneddon, Sovan Sarkar, Oliver Busby, Elena Seraia, Chiara Toffanin, Christian R. Cooper, Michalis Challoumas, Fiona Akinyi Okonjo et al. · 2026 · Research Square
- DT-TRAP enables accurate target recognition via simplified dosing and low-temperature incubationHeng Zhang, Wenjie Yuan, Yi Li, Chunyu Li, Yizhou Xie, Ning Wan, Haiping Hao, Hui Ye · 2026 · Journal of Pharmaceutical Analysis
- Variant-dependent pharmacological rescue of phenylalanine hydroxylase supports a precision therapeutic strategy for phenylketonuriaMaría Conde-Giménez, Sandra Salillas, María Galiana‐Cameo, Juan Martínez-Oliván, Alejandro Mahía, Manuel Ledesma, Juan José Galano‐Frutos, Ritwik Maity, Adrián Velázquez‐Campoy, Maria Dolores Diaz-De-Villegas et al. · 2026 · Biomedicine & Pharmacotherapy
- Temperature Range Thermal Proteome Profiling for Drug Target Identification: A Practical GuideYi Xue, Peiyu Chen, Meining Xing, Lifeng Han, Wantao Ying · 2026 · Journal of Proteome Research
- Emerging technologies in environmental toxicology based on pollutant-protein interactionsYang Xin, Zheyi Liu, Yangyang Bian, Yufeng Gong, 耿柠波, 张海军, Fangjun Wang, Jiping Chen · 2026 · Scientia Sinica Chimica
- The Discovery of GSK3227634: A Potent Inhaled Inhibitor of the KEAP1/NRF2 Protein–Protein Interaction for the Treatment of Chronic Obstructive Pulmonary DiseaseJames F. Callahan, Thomas G. Davies, Marcus Bantscheff, Sabrina Bédard, Jeffrey D. Boehm, Catherine L. Booth-Genthe, N.O. Concha, Royston C. B. Copley, Alicia Davis, Roderick Davis et al. · 2026 · Journal of Medicinal Chemistry
- Gene Families, Structural and Functional Contexts Shape Protein Thermostability and Paralog Divergence in ArabidopsisYanli Cheng, Wenqing Zhang, Feng Sun, Zhitao Hu, Zongbo Han, Junlong Zhou, Haining Dong, Weizhong Liu, Wenqing Shi · 2026 · Plants
- Proteogenomic Analysis of HDAC4 and HDAC5 in Uveal MelanomaSvenja Mergener, Tanja J. Kutzner, Martin Schneider, Teresa González-Gimeno, Yue Zheng, Utta Berchner‐Pfannschmidt, Dominic Helm, Bernd Giebel, Nikolaos Emmanouel Bechrakis, Samuel Peña‐Llopis · 2026 · Molecular Medicine
- Proteomic Technologies for Decoding Drug-Protein Interactions in Living CellsTing YU, Mingliang YE · 2026 · Analysis and Testing Technology and Instruments
- BindingDB Entry 50016197: A Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Assay Identifies Nilotinib as an Inhibitor of Inflammation in Acute Myeloid Leukemia.BindingDB · 2023 · UC San Diego
- BindingDB Entry 50023059: Phenotype-Led Identification of IL-10 Upregulators in Human CD4+ T-cells and Elucidation of Their Pharmacology as Highly Selective CDK8/CDK19 Inhibitors.BindingDB · 2026 · UC San Diego
- BindingDB Entry 50002439: Emerging Approaches for the Identification of Protein Targets of Small Molecules - A Practitioners' Perspective.BindingDB · 2020 · UC San Diego