Becher, Isabelle

Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes

Bantscheff, M., Hopf, C., Savitski, M. M., Dittmann, A., Grandi, P., Michon, A.-M., Schlegl, J., Abraham, Y., Becher, I., Bergamini, G., et al. (2011) · Nature Biotechnology

Histone Deacetylase Inhibitors ResearchAdvanced Proteomics Techniques and Applications

Cited by 659

Thermal proteome profiling for interrogating protein interactions

Mateus, A., Kurzawa, N., Becher, I., Sridharan, S., Helm, D., Stein, F., Typas, A., & Savitski, M. M. (2020) · Molecular Systems Biology

Advanced Proteomics Techniques and Applicationsthermodynamics and calorimetric analyses

Cited by 258

Thermal profiling reveals phenylalanine hydroxylase as an off-target of panobinostat

Becher, I., Werner, T., Doce, C., Zaal, E. A., Tögel, I., Khan, C. A., Rueger, A., Muelbaier, M., Salzer, E., Berkers, C. R., et al. (2016) · Nature Chemical Biology

Advanced Proteomics Techniques and ApplicationsHistone Deacetylase Inhibitors Research

Cited by 251

Identifying drug targets in tissues and whole blood with thermal-shift profiling

Perrin, J., Werner, T., Kurzawa, N., Rutkowska, A., Childs, D. D., Kalxdorf, M., Poeckel, D., Stonehouse, E., Strohmer, K., Heller, B., et al. (2020) · Nature Biotechnology

Advanced Proteomics Techniques and ApplicationsProtein Degradation and Inhibitors

Cited by 178

Impact of phosphorylation on thermal stability of proteins

Potel, C. M., Kurzawa, N., Becher, I., Typas, A., Mateus, A., & Savitski, M. M. (2021) · Nature Methods

Protein Structure and DynamicsAdvanced Proteomics Techniques and Applications

Cited by 103

Chemoproteomics Reveals Time-Dependent Binding of Histone Deacetylase Inhibitors to Endogenous Repressor Complexes

Becher, I., Dittmann, A., Savitski, M. M., Hopf, C., Drewes, G., & Bantscheff, M. (2014) · ACS Chemical Biology

Histone Deacetylase Inhibitors ResearchAdvanced Proteomics Techniques and Applications

Cited by 60

A computational method for detection of ligand-binding proteins from dose range thermal proteome profiles

Kurzawa, N., Becher, I., Sridharan, S., Franken, H., Mateus, A., Anders, S., Bantscheff, M., Huber, W., & Savitski, M. M. (2020) · Nature Communications

Advanced Proteomics Techniques and Applicationsthermodynamics and calorimetric analyses

Cited by 53

Molecular profiling of sponge deflation reveals an ancient relaxant-inflammatory response

Ruperti, F., Becher, I., Stokkermans, A., Wang, L., Marschlich, N., Potel, C., Maus, E., Stein, F., Drotleff, B., Schippers, K., et al. (2023) · Current Biology

Marine Invertebrate Physiology and EcologyMarine Sponges and Natural Products

Cited by 23

Molecular profiling of sponge deflation reveals an ancient relaxant-inflammatory response

Ruperti, F., Becher, I., Stokkermans, A., Wang, L., Marschlich, N., Potel, C., Maus, E., Stein, F., Drotleff, B., Schippers, K. J., et al. (2024) · Current Biology

Marine Invertebrate Physiology and EcologyMarine Sponges and Natural Products

Cited by 23

High-throughput peptide-centric local stability assay extends protein-ligand identification to membrane proteins, tissues, and bacteria

Li, K., Potel, C. M., Becher, I., Hüttmann, N., Garrido-Rodriguez, M., Schwarz, J., & Savitski, M. M. (2025) · Nature Structural & Molecular Biology

Mass Spectrometry Techniques and ApplicationsAdvanced Proteomics Techniques and Applications

Cited by 8

Multi-omics and biophysical phosphoproteomics upon BRAF inhibition uncover functional networks of BRAFV600E-driven signaling

Burtscher, M. L., Garrido-Rodriguez, M., Rivera Mejias, P. A., Papagiannidis, D., Becher, I., Selegato, D. M., Potel, C., Jung, F., Zimmermann, M., Saez-Rodriguez, J., et al. (2026) · bioRxiv

Melanoma and MAPK PathwaysProtein Kinase Regulation and GTPase Signaling

Cited by 0