Savitski, Mikhail M.

Mass-spectrometry-based draft of the human proteome

Wilhelm, M., Schlegl, J., Hahne, H., Gholami, A. M., Lieberenz, M., Savitski, M. M., Ziegler, E., Butzmann, L., Gessulat, S., Marx, H., et al. (2014) · Nature

Advanced Proteomics Techniques and ApplicationsBioinformatics and Genomic Networks

Cited by 1,820

Tracking cancer drugs in living cells by thermal profiling of the proteome

Savitski, M. M., Reinhard, F. B. M., Franken, H., Werner, T., Savitski, M. F., Eberhard, D., Molina, D. M., Jafari, R., Dovega, R. B., Klaeger, S., et al. (2014) · Science

Advanced Proteomics Techniques and Applicationsthermodynamics and calorimetric analyses

Cited by 1,187

Quantitative mass spectrometry in proteomics: critical review update from 2007 to the present

Bantscheff, M., Lemeer, S., Savitski, M. M., & Kuster, B. (2012) · Analytical and Bioanalytical Chemistry

Advanced Proteomics Techniques and ApplicationsMass Spectrometry Techniques and Applications

Cited by 801

Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes

Bantscheff, M., Hopf, C., Savitski, M. M., Dittmann, A., Grandi, P., Michon, A.-M., Schlegl, J., Abraham, Y., Becher, I., Bergamini, G., et al. (2011) · Nature Biotechnology

Histone Deacetylase Inhibitors ResearchAdvanced Proteomics Techniques and Applications

Cited by 659

The functional landscape of the human phosphoproteome

Ochoa, D., Jarnuczak, A. F., Viéitez, C., Gehre, M., Soucheray, M., Mateus, A., Kleefeldt, A. A., Hill, A., Garcia-Alonso, L., Stein, F., et al. (2020) · Nature Biotechnology

Advanced Proteomics Techniques and ApplicationsBioinformatics and Genomic Networks

Cited by 491

Thermal proteome profiling for interrogating protein interactions

Mateus, A., Kurzawa, N., Becher, I., Sridharan, S., Helm, D., Stein, F., Typas, A., & Savitski, M. M. (2020) · Molecular Systems Biology

Advanced Proteomics Techniques and Applicationsthermodynamics and calorimetric analyses

Cited by 258

Thermal profiling reveals phenylalanine hydroxylase as an off-target of panobinostat

Becher, I., Werner, T., Doce, C., Zaal, E. A., Tögel, I., Khan, C. A., Rueger, A., Muelbaier, M., Salzer, E., Berkers, C. R., et al. (2016) · Nature Chemical Biology

Advanced Proteomics Techniques and ApplicationsHistone Deacetylase Inhibitors Research

Cited by 251

Identifying drug targets in tissues and whole blood with thermal-shift profiling

Perrin, J., Werner, T., Kurzawa, N., Rutkowska, A., Childs, D. D., Kalxdorf, M., Poeckel, D., Stonehouse, E., Strohmer, K., Heller, B., et al. (2020) · Nature Biotechnology

Advanced Proteomics Techniques and ApplicationsProtein Degradation and Inhibitors

Cited by 178

Bacterial retrons encode phage-defending tripartite toxin–antitoxin systems

Bobonis, J., Mitosch, K., Mateus, A., Karcher, N., Kritikos, G., Selkrig, J., Zietek, M., Monzon, V., Pfalz, B., Garcia-Santamarina, S., et al. (2022) · Nature

Bacteriophages and microbial interactionsBacterial Genetics and Biotechnology

Cited by 165

Structure of the mycobacterial ESX-5 type VII secretion system membrane complex by single-particle analysis

Beckham, K. S. H., Ciccarelli, L., Bunduc, C. M., Mertens, H. D. T., Ummels, R., Lugmayr, W., Mayr, J., Rettel, M., Savitski, M. M., Svergun, D. I., et al. (2017) · Nature Microbiology

Tuberculosis Research and EpidemiologyBacterial Genetics and Biotechnology

Cited by 112

Impact of phosphorylation on thermal stability of proteins

Potel, C. M., Kurzawa, N., Becher, I., Typas, A., Mateus, A., & Savitski, M. M. (2021) · Nature Methods

Protein Structure and DynamicsAdvanced Proteomics Techniques and Applications

Cited by 103

The outer membrane lipoprotein NlpI nucleates hydrolases within peptidoglycan multi-enzyme complexes in Escherichia coli

Banzhaf, M., Yau, H. C. L., Verheul, J., Lodge, A., Kritikos, G., Mateus, A., Hov, A. K., Stein, F., Wartel, M., Pazos, M., et al. (2019) · The EMBO Journal

Bacterial Genetics and BiotechnologyEscherichia coli research studies

Cited by 89

Chemoproteomics Reveals Time-Dependent Binding of Histone Deacetylase Inhibitors to Endogenous Repressor Complexes

Becher, I., Dittmann, A., Savitski, M. M., Hopf, C., Drewes, G., & Bantscheff, M. (2014) · ACS Chemical Biology

Histone Deacetylase Inhibitors ResearchAdvanced Proteomics Techniques and Applications

Cited by 60

A computational method for detection of ligand-binding proteins from dose range thermal proteome profiles

Kurzawa, N., Becher, I., Sridharan, S., Franken, H., Mateus, A., Anders, S., Bantscheff, M., Huber, W., & Savitski, M. M. (2020) · Nature Communications

Advanced Proteomics Techniques and Applicationsthermodynamics and calorimetric analyses

Cited by 53

Aggregation and disaggregation features of the human proteome

Määttä, T. A., Rettel, M., Sridharan, S., Helm, D., Kurzawa, N., Stein, F., & Savitski, M. M. (2020) · Molecular Systems Biology

Heat shock proteins researchAdvanced Proteomics Techniques and Applications

Cited by 34

Molecular profiling of sponge deflation reveals an ancient relaxant-inflammatory response

Ruperti, F., Becher, I., Stokkermans, A., Wang, L., Marschlich, N., Potel, C., Maus, E., Stein, F., Drotleff, B., Schippers, K., et al. (2023) · Current Biology

Marine Invertebrate Physiology and EcologyMarine Sponges and Natural Products

Cited by 23

Molecular profiling of sponge deflation reveals an ancient relaxant-inflammatory response

Ruperti, F., Becher, I., Stokkermans, A., Wang, L., Marschlich, N., Potel, C., Maus, E., Stein, F., Drotleff, B., Schippers, K. J., et al. (2024) · Current Biology

Marine Invertebrate Physiology and EcologyMarine Sponges and Natural Products

Cited by 23

High-throughput peptide-centric local stability assay extends protein-ligand identification to membrane proteins, tissues, and bacteria

Li, K., Potel, C. M., Becher, I., Hüttmann, N., Garrido-Rodriguez, M., Schwarz, J., & Savitski, M. M. (2025) · Nature Structural & Molecular Biology

Mass Spectrometry Techniques and ApplicationsAdvanced Proteomics Techniques and Applications

Cited by 8

Transient Glycolytic Complexation of Arsenate Enhances Resistance in the Enteropathogen Vibrio cholerae

Bueno, E., Pinedo, V., Shinde, D. D., Mateus, A., Typas, A., Savitski, M. M., Thomas, V. C., & Cava, F. (2022) · mBio

Arsenic contamination and mitigationBacterial Genetics and Biotechnology

Cited by 6

Transient glycolytic complexation of arsenate enhances resistance in the enteropathogen Vibrio cholerae

Bueno, E., Pinedo, V., Shinde, D. D., Mateus, A., Typas, A., Savitski, M. M., Thomas, V. C., & Cava, F. (2022) · mBio

Arsenic contamination and mitigationBacterial Genetics and Biotechnology

Cited by 6

Multi-omics and biophysical phosphoproteomics upon BRAF inhibition uncover functional networks of BRAFV600E-driven signaling

Burtscher, M. L., Garrido-Rodriguez, M., Rivera Mejias, P. A., Papagiannidis, D., Becher, I., Selegato, D. M., Potel, C., Jung, F., Zimmermann, M., Saez-Rodriguez, J., et al. (2026) · bioRxiv

Melanoma and MAPK PathwaysProtein Kinase Regulation and GTPase Signaling

Cited by 0