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Mutations along a TET2 active site scaffold stall oxidation at 5-hydroxymethylcytosine
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“We further used a Tet2 mutant that stalls TET2-mediated oxidation at the hm5C stage42. The IAP half-life profile of HSPCs from this mutant is similar to that of WT HSPCs, suggesting that potential hm5C oxidation by TET2 may not further contribute to IAP destabilization.”
From RNA m5C oxidation by TET2 regulates chromatin state and leukaemogenesis (2024) · cites this paper as [42]
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The Amber biomolecular simulation programs
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Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine
Ito, S., Shen, L., Dai, Q., Wu, S. C., Collins, L. B., Swenberg, J. A., He, C., & Zhang, Y. (2011) · Science · doi:10.1126/science.1210597 · Cited by 3,451
The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain
Kriaucionis, S., & Heintz, N. (2009) · Science · doi:10.1126/science.1169786 · Cited by 2,700
TET enzymes, TDG and the dynamics of DNA demethylation
Kohli, R. M., & Zhang, Y. (2013) · Nature · doi:10.1038/nature12750 · Cited by 1,623
Self-citationDynamic Readers for 5-(Hydroxy)Methylcytosine and Its Oxidized Derivatives
Spruijt, C. G., Gnerlich, F., Smits, A. H., Pfaffeneder, T., Jansen, P. W. T. C., Bauer, C., Münzel, M., Wagner, M., Müller, M., Khan, F., et al. (2013) · Cell · doi:10.1016/j.cell.2013.02.004 · Cited by 973
Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma
Lian, C. G., Xu, Y., Ceol, C., Wu, F., Larson, A., Dresser, K., Xu, W., Tan, L., Hu, Y., Zhan, Q., et al. (2012) · Cell · doi:10.1016/j.cell.2012.07.033 · Cited by 789
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Cited by
TET-mediated active DNA demethylation: mechanism, function and beyond
Wu, X., & Zhang, Y. (2017) · Nature Reviews Genetics · doi:10.1038/nrg.2017.33 · Cited by 1,661
Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells
Fraietta, J. A., Nobles, C. L., Sammons, M. A., Lundh, S., Carty, S. A., Reich, T. J., Cogdill, A. P., Morrissette, J. J. D., DeNizio, J. E., Reddy, S., et al. (2018) · Nature · doi:10.1038/s41586-018-0178-z · Cited by 862
Self-citationRNA m5C oxidation by TET2 regulates chromatin state and leukaemogenesis
Zou, Z., Dou, X., Li, Y., Zhang, Z., Wang, J., Gao, B., Xiao, Y., Wang, Y., Zhao, L., Sun, C., et al. (2024) · Nature · doi:10.1038/s41586-024-07969-x · Cited by 103
TET-TDG active DNA demethylation at CpG and non-CpG sites
DeNizio, J. E., Dow, B. J., Serrano, J. C., Ghanty, U., Drohat, A. C., & Kohli, R. M. (2021) · Journal of Molecular Biology · doi:10.1016/j.jmb.2021.166877 · Cited by 32
Metadata
- Authors
- Liu, M. Y., Torabifard, H., Crawford, D. J., DeNizio, J. E., Cao, X.-J., Garcia, B. A., Cisneros, G. A., & Kohli, R. M.
- Venue
- Nature Chemical Biology
- Published
- 2016-12-05
- Volume
- 13
- Issue
- 2
- Pages
- 181-187
- ISSN
- 1552-4450
- 1552-4469
- PMC
- PMC5370579
- Cited by
- 78
- References
- 6
- Language
- en
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