Cited by 769Histone Deacetylase Inhibitors ResearchEnzyme function and inhibitionCholinesterase and Neurodegenerative Diseases

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Chemical phylogenetics of histone deacetylases

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Bradner, James E, West, Nathan, Grachan, Melissa L, Greenberg, Edward F, Haggarty, Stephen J, Warnow, Tandy, Mazitschek, Ralph·2010·Nature Chemical Biology

DOI 10.1038/nchembio.313PMC PMC2822059

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Abstract

The broad study of histone deacetylases in chemistry, biology and medicine relies on tool compounds to derive mechanistic insights. A phylogenetic analysis of Class I and II HDACs as targets of a comprehensive, structurally diverse panel of inhibitors revealed unexpected isoform selectivity even among compounds widely perceived as non-selective. The synthesis and study of a focused library of cinnamic hydroxamates allowed the identification of a first non-selective HDAC inhibitor. These data will guide a more informed use of HDAC inhibitors as chemical probes and therapeutic agents.

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Additional file 4 of The pan HDAC inhibitor Givinostat improves muscle function and histological parameters in two Duchenne muscular dystrophy murine models expressing different haplotypes of the LTBP4 gene
Licandro, S. A., Crippa, L., Pomarico, R., Perego, R., Fossati, G., Leoni, F., & Steinkühler, C. (2021) · Figshare · doi:10.6084/m9.figshare.15041206
Additional file 5 of The pan HDAC inhibitor Givinostat improves muscle function and histological parameters in two Duchenne muscular dystrophy murine models expressing different haplotypes of the LTBP4 gene
Licandro, S. A., Crippa, L., Pomarico, R., Perego, R., Fossati, G., Leoni, F., & Steinkühler, C. (2021) · Figshare · doi:10.6084/m9.figshare.15041209
The effect of histone deacetylase inhibitors on SRC and BCL2L1 gene expression and a potential role for phosphatases in their transcriptional repression
Chapman, S. (2013) · University Library - University of Saskatchewan (University of Saskatchewan)
Additional file 2 of The pan HDAC inhibitor Givinostat improves muscle function and histological parameters in two Duchenne muscular dystrophy murine models expressing different haplotypes of the LTBP4 gene
Licandro, S. A., Crippa, L., Pomarico, R., Perego, R., Fossati, G., Leoni, F., & Steinkühler, C. (2021) · Figshare · doi:10.6084/m9.figshare.15041200
Additional file 1 of The pan HDAC inhibitor Givinostat improves muscle function and histological parameters in two Duchenne muscular dystrophy murine models expressing different haplotypes of the LTBP4 gene
Licandro, S. A., Crippa, L., Pomarico, R., Perego, R., Fossati, G., Leoni, F., & Steinkühler, C. (2021) · Figshare · doi:10.6084/m9.figshare.15041197
Additional file 6 of The pan HDAC inhibitor Givinostat improves muscle function and histological parameters in two Duchenne muscular dystrophy murine models expressing different haplotypes of the LTBP4 gene
Licandro, S. A., Crippa, L., Pomarico, R., Perego, R., Fossati, G., Leoni, F., & Steinkühler, C. (2021) · Figshare · doi:10.6084/m9.figshare.15041212
Additional file 3 of The pan HDAC inhibitor Givinostat improves muscle function and histological parameters in two Duchenne muscular dystrophy murine models expressing different haplotypes of the LTBP4 gene
Licandro, S. A., Crippa, L., Pomarico, R., Perego, R., Fossati, G., Leoni, F., & Steinkühler, C. (2021) · Figshare · doi:10.6084/m9.figshare.15041203
Additional file 7 of The pan HDAC inhibitor Givinostat improves muscle function and histological parameters in two Duchenne muscular dystrophy murine models expressing different haplotypes of the LTBP4 gene
Licandro, S. A., Crippa, L., Pomarico, R., Perego, R., Fossati, G., Leoni, F., & Steinkühler, C. (2021) · Figshare · doi:10.6084/m9.figshare.15041215
Design and development of 1,5-diarylpyrazole-based multitarget-directed ligands as dual COX-2/HDAC6 inhibitors for Alzheimer's disease therapy: Molecular dynamics and experimental insights
Abdelrahman, K. S., Soltan, O. M., Mansour, H. E. A., Nofal, A. E., Eissa, E. A., Salem, H. R., Mahfouz, M. M., El‐Adawy, S. A., Ewies, G. S. A., Hamdi, A., et al. (2026) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2026.118738
The gut-heart dialogue: an epigenetic perspective on myocardial infarction
Song, J., Tang, S., Guo, Y., Hong, C., & Song, T. (2026) · npj Biofilms and Microbiomes · doi:10.1038/s41522-026-00974-0 · Cited by 1

Authors: Bradner, J. E., West, N., Grachan, M. L., Greenberg, E. F., Haggarty, S. J., Warnow, T., & Mazitschek, R.
Affiliations: Broad Institute (US)
Harvard University (US)
The University of Texas at Austin (US)
Corresponding author: Bradner, James E
Mazitschek, Ralph
ORCID: Bradner, James E
Greenberg, Edward F
Haggarty, Stephen J
Warnow, Tandy
Mazitschek, Ralph
Venue: Nature Chemical Biology
Publisher: Springer Science and Business Media LLC
Published: 2010-02-07
Volume: 6
Issue: 3
Pages: 238-243
ISSN: 1552-4450 (ISSN-L)
1552-4469
DOI: 10.1038/nchembio.313
PMC: PMC2822059
OpenAlex: W2083784041
Semantic Scholar: 68c4985bcae290a761e64065e7e4cfe062700c7f
Cited by: 720
References: 31
Citations by year: 2026: 18 · 2025: 25 · 2024: 27 · 2023: 28 · 2022: 37 · 2021: 50 · 2020: 41 · 2019: 34 · 2018: 39 · 2017: 42 · 2016: 61 · 2015: 64 · 2014: 53 · 2013: 67 · 2012: 62
FWCI: 27.21
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature Chemical Biology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Wellcome Trust
National Institutes of Health (n01co12400-79-0-22)
Centers for Disease Control and Prevention (N01-C0-012400)
National Institute on Drug Abuse (R01DA028301)
National Cancer Institute (N01-CO-012400, K08CA128972, P01CA078048, T32CA079443)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Histone Deacetylase Inhibitors Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Enzyme function and inhibition
Health Sciences › Medicine › Pharmacology (medical) › Cholinesterase and Neurodegenerative Diseases
Keywords: histone deacetylase, histone deacetylase inhibitors, isoform selectivity, class I HDACs, class II HDACs, class IIa HDACs, focused libraries, chemical probes, enzyme inhibition mechanism

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Chemical phylogenetics of histone deacetylases

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