The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Signaling-mediated bacterial persister formation
Open accessAbstract
Here we show that bacterial communication through indole signaling induces persistence, a phenomenon in which a subset of an isogenic bacterial population tolerates antibiotic treatment. We monitor indole-induced persister formation using microfluidics, and identify the role of oxidative stress and phage-shock pathways in this phenomenon. We propose a model in which indole signaling “inoculates” a bacterial sub-population against antibiotics by activating stress responses, leading to persister formation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Bacterial Persistence as a Phenotypic Switch
Balaban, N. Q., Merrin, J., Chait, R., Kowalik, L., & Leibler, S. (2004) · Science · doi:10.1126/science.1099390 · Cited by 2,952
Persister cells, dormancy and infectious disease
Lewis, K. (2007) · Nature Reviews Microbiology · doi:10.1038/nrmicro1557 · Cited by 2,052
Persister cells and tolerance to antimicrobials
Keren, I., Kaldalu, N., Spoering, A., Wang, Y., & Lewis, K. (2004) · FEMS Microbiology Letters · doi:10.1016/s0378-1097(03)00856-5 · Cited by 1,098
Metabolite-enabled eradication of bacterial persisters by aminoglycosides
Allison, K. R., Brynildsen, M. P., & Collins, J. J. (2011) · Nature · doi:10.1038/nature10069 · Cited by 1,025
Self-citationBassler, B. L., & Losick, R. (2006) · Cell · doi:10.1016/j.cell.2006.04.001 · Cited by 983
Bacterial charity work leads to population-wide resistance
Lee, H. H., Molla, M. N., Cantor, C. R., & Collins, J. J. (2010) · Nature · doi:10.1038/nature09354 · Cited by 638
Self-citationMoyed, H. S., & Bertrand, K. P. (1983) · Journal of Bacteriology · doi:10.1128/jb.155.2.768-775.1983 · Cited by 625
Non-inherited antibiotic resistance
Levin, B. R., & Rozen, D. E. (2006) · Nature Reviews Microbiology · doi:10.1038/nrmicro1445 · Cited by 542
Wang, X., & Wood, T. K. (2011) · Applied and Environmental Microbiology · doi:10.1128/aem.05068-11 · Cited by 433
Regulation of phenotypic variability by a threshold-based mechanism underlies bacterial persistence
Rotem, E., Loinger, A., Ronin, I., Levin-Reisman, I., Gabay, C., Shoresh, N., Biham, O., & Balaban, N. Q. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1004333107 · Cited by 355
Cited by
The Application of Ecological Theory Toward an Understanding of the Human Microbiome
Costello, E. K., Stagaman, K., Dethlefsen, L., Bohannan, B. J. M., & Relman, D. A. (2012) · Science · doi:10.1126/science.1224203 · Cited by 1,437
Definitions and guidelines for research on antibiotic persistence
Balaban, N. Q., Helaine, S., Lewis, K., Ackermann, M., Aldridge, B., Andersson, D. I., Brynildsen, M. P., Bumann, D., Camilli, A., Collins, J. J., et al. (2019) · Nature Reviews Microbiology · doi:10.1038/s41579-019-0196-3 · Cited by 1,313
Self-citationAntibiotic resistance and persistence—implications for human health and treatment perspectives
Huemer, M., Mairpady Shambat, S., Brugger, S. D., & Zinkernagel, A. S. (2020) · The EMBO Reports · doi:10.15252/embr.202051034 · Cited by 850
Antibiotics and the Gut Microbiota
Modi, S. R., Collins, J. J., & Relman, D. A. (2014) · Journal of Clinical Investigation · doi:10.1172/jci72333 · Cited by 667
Self-citationRoles of indole as an interspecies and interkingdom signaling molecule
Lee, J.-H., Wood, T. K., & Lee, J. (2015) · Trends in Microbiology · doi:10.1016/j.tim.2015.08.001 · Cited by 516
Metadata
- Authors
- Vega, N. M., Allison, K. R., Khalil, A. S., & Collins, J. J.
- Venue
- Nature Chemical Biology
- Published
- 2012-03-18
- Volume
- 8
- Issue
- 5
- Pages
- 431-433
- ISSN
- 1552-4450 (ISSN-L)
- 1552-4469
- OpenAlex
- W2009265628
- Cited by
- 414
- References
- 25
- FWCI
- 21.26
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Signaling-mediated bacterial persister formation. https://app.cochat.ai/papers/10.1038/nchembio.915
- The paper
- Vega, N. M., Allison, K. R., Khalil, A. S., & Collins, J. J. (2012). Signaling-mediated bacterial persister formation. Nature Chemical Biology. https://doi.org/10.1038/nchembio.915
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
