The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
A combinatorial TIR1/AFB–Aux/IAA co-receptor system for differential sensing of auxin
Open accessAbstract
The plant hormone auxin regulates virtually every aspect of plant growth and development. Auxin acts by binding to the F-box protein TIR1 and promotes the degradation of the Aux/IAA transcriptional repressors. Here, we show that efficient auxin binding requires assembly of an auxin co-receptor complex consisting of TIR1 and an Aux/IAA protein. Heterologous experiments in yeast and quantitative IAA binding assays using purified proteins showed that different combinations of TIR1 and Aux/IAA proteins form co-receptor complexes with a wide range of auxin-binding affinities. Auxin affinity appears to be largely determined by the Aux/IAA. As there are 6 TIR1/AFBs and 29 Aux/IAA proteins in Arabidopsis thaliana, combinatorial interactions may result in many co-receptors with distinct auxin sensing properties. We also demonstrate that the AFB5-Aux/IAA co-receptor selectively binds the auxinic herbicide picloram. This co-receptor system broadens the effective concentration range of the hormone and may contribute to the complexity of auxin response.
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Cites
PROCHECK: a program to check the stereochemical quality of protein structures
Laskowski, R. A., MacArthur, M. W., Moss, D. S., & Thornton, J. M. (1993) · Journal of Applied Crystallography · doi:10.1107/s0021889892009944 · Cited by 24,581
The F-box protein TIR1 is an auxin receptor
Dharmasiri, N., Dharmasiri, S., & Estelle, M. (2005) · Nature · doi:10.1038/nature03543 · Cited by 2,083
Self-citationMechanism of auxin perception by the TIR1 ubiquitin ligase
Tan, X., Calderon-Villalobos, L. I. A., Sharon, M., Zheng, C., Robinson, C. V., Estelle, M., & Zheng, N. (2007) · Nature · doi:10.1038/nature05731 · Cited by 1,688
Self-citationAn auxin-based degron system for the rapid depletion of proteins in nonplant cells
Nishimura, K., Fukagawa, T., Takisawa, H., Kakimoto, T., & Kanemaki, M. (2009) · Nature Methods · doi:10.1038/nmeth.1401 · Cited by 1,663
Plant Development Is Regulated by a Family of Auxin Receptor F Box Proteins
Dharmasiri, N., Dharmasiri, S., Weijers, D., Lechner, E., Yamada, M., Hobbie, L., Ehrismann, J. S., Jürgens, G., & Estelle, M. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.05.014 · Cited by 997
Self-citationAuxin Perception--Structural Insights
Calderon-Villalobos, L. I., Tan, X., Zheng, N., & Estelle, M. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005546 · Cited by 177
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Cited by
Leyser, O. (2018) · Plant Physiology · doi:10.1104/pp.17.00765 · Cited by 715
SAUR Proteins as Effectors of Hormonal and Environmental Signals in Plant Growth
Ren, H., & Gray, W. M. (2015) · Molecular Plant · doi:10.1016/j.molp.2015.05.003 · Cited by 579
SCFTIR1/AFB-Based Auxin Perception: Mechanism and Role in Plant Growth and Development
Salehin, M., Bagchi, R., & Estelle, M. (2015) · The Plant Cell · doi:10.1105/tpc.114.133744 · Cited by 462
Self-citationAuxin activity: Past, present, and future
Enders, T. A., & Strader, L. C. (2015) · American Journal of Botany · doi:10.3732/ajb.1400285 · Cited by 355
Diversity and specificity: auxin perception and signaling through the TIR1/AFB pathway
Wang, R., & Estelle, M. (2014) · Current Opinion in Plant Biology · doi:10.1016/j.pbi.2014.06.006 · Cited by 290
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Metadata
- Authors
- Calderón Villalobos, L. I. A., Lee, S., De Oliveira, C., Ivetac, A., Brandt, W., Armitage, L., Sheard, L. B., Tan, X., Parry, G., Mao, H., Zheng, N., Napier, R., Kepinski, S., & Estelle, M.
- Venue
- Nature Chemical Biology
- Published
- 2012-04-01
- Volume
- 8
- Issue
- 5
- Pages
- 477-485
- ISSN
- 1552-4450 (ISSN-L)
- 1552-4469
- OpenAlex
- W2067478074
- Cited by
- 590
- References
- 6
- FWCI
- 57.02
- Type
- journal article
- Language
- en
- Open access
- green
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- Calderón Villalobos, L. I. A., Lee, S., De Oliveira, C., Ivetac, A., Brandt, W., Armitage, L., Sheard, L. B., Tan, X., Parry, G., Mao, H., Zheng, N., Napier, R., Kepinski, S., & Estelle, M. (2012). A combinatorial TIR1/AFB–Aux/IAA co-receptor system for differential sensing of auxin. Nature Chemical Biology. https://doi.org/10.1038/nchembio.926
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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