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Cited by 231

The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.

Hypomethylation of smoking-related genes is associated with future lung cancer in four prospective cohorts

Open access
Fasanelli, Francesca, Baglietto, Laura, Ponzi, Erica, Guida, Florence, Campanella, Gianluca, Johansson, Mattias, Grankvist, Kjell, Johansson, Mikael, Assumma, Manuela Bianca, Naccarati, Alessio, Chadeau-Hyam, Marc, Ala, Ugo, Faltus, Christian, Kaaks, Rudolf, Risch, Angela, De Stavola, Bianca, Hodge, Allison, Giles, Graham G., Southey, Melissa C., Relton, Caroline L., Haycock, Philip C., Lund, Eiliv, Polidoro, Silvia, Sandanger, Torkjel M., Severi, Gianluca, Vineis, Paolo·2015·Nature Communications
DOI 10.1038/ncomms10192
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Abstract

DNA hypomethylation in certain genes is associated with tobacco exposure but it is unknown whether these methylation changes translate into increased lung cancer risk. In an epigenome-wide study of DNA from pre-diagnostic blood samples from 132 case–control pairs in the NOWAC cohort, we observe that the most significant associations with lung cancer risk are for cg05575921 in AHRR (OR for 1 s.d.=0.37, 95% CI: 0.31–0.54, P -value=3.3 × 10 −11 ) and cg03636183 in F2RL3 (OR for 1 s.d.=0.40, 95% CI: 0.31–0.56, P -value=3.9 × 10 −10 ), previously shown to be strongly hypomethylated in smokers. These associations remain significant after adjustment for smoking and are confirmed in additional 664 case–control pairs tightly matched for smoking from the MCCS, NSHDS and EPIC HD cohorts. The replication and mediation analyses suggest that residual confounding is unlikely to explain the observed associations and that hypomethylation of these CpG sites may mediate the effect of tobacco on lung cancer risk.

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Metadata

Authors
Fasanelli, F., Baglietto, L., Ponzi, E., Guida, F., Campanella, G., Johansson, M., Grankvist, K., Johansson, M., Assumma, M. B., Naccarati, A., Chadeau-Hyam, M., Ala, U., Faltus, C., Kaaks, R., Risch, A., De Stavola, B., Hodge, A., Giles, G. G., Southey, M. C., Relton, C. L., Haycock, P. C., Lund, E., Polidoro, S., Sandanger, T. M., Severi, G., & Vineis, P.
Venue
Nature Communications
Publisher
Springer Science and Business Media LLC
Published
2015-12-15
Volume
6
Issue
1
Pages
10192-10192
ISSN
2041-1723 (ISSN-L)
DOI
10.1038/ncomms10192
OpenAlex
W2204204249
Cited by
231
References
10
FWCI
8.23
Type
journal article
Language
en
Open access
gold

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