Network-based in silico drug efficacy screening

Guney, Emre, Menche, Jörg, Vidal, Marc, Barábasi, Albert-László·2016·Nature Communications

Cited by (643)

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  1. Network-based approach highlighting interplay among anti-hypertensives: target coding-genes: diseases
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  2. FAIR and bias-free network modules for mechanism-based disease redefinitions
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  3. Tangible heart, silicon brain
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  4. Lung Disease Network Reveals the Impact of Comorbidity on SARS-CoV-2 Infection and Opportunities of Drug Repurposing
    Asim Bikas Das · 2020 · Research Square
  5. Conclusion
    Sriganesh Srihari, Chern Han Yong, Limsoon Wong · 2017
  6. Faculty Opinions recommendation of A network-based approach to identify deregulated pathways and drug effects in metabolic syndrome.
    Saikat Chakrabarti · 2020 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  7. References
    Sriganesh Srihari, Chern Han Yong, Limsoon Wong · 2017
  8. Preface
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  9. Network medicine approaches to diagnostics and therapeutics
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  21. Network proximity analysis as a theoretical model for identifying potential novel therapies in primary sclerosing cholangitis
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  22. Role of Artificial Intelligence (AI) and Machine Learning (ML) in Drug Purposing
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  23. Study of the role of leukocyte telomere length-related lncRNA NBR2 in Alzheimer’s disease
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  24. HeteroRepur: Efficient Modeling of Heterogeneous Disease Graph for Depression Drug Repurposing using Heterogeneous Graph Neural Networks
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  27. Network Medicine Framework Links Chemical Classes to Physiological System-specific Therapeutic Benefits
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  31. Generating a Trustworthy Hypergraph for Traditional Chinese Medicine Prescription Evaluation and Screening
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  33. Literature data-based de novo candidates for drug repurposing
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  34. Extracellular Matrix-Guided Tumor Stratification and Network Models Reveal Clinical Molecular Grades
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  36. CombDNF: Disease-Specific drug combination predictions with network-based features on clinically validated data
    Pauline Hiort, Bernhard Y. Renard, Katharina Baum · 2025 · IEEE Conference on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB)
  37. Systems Pharmacology Model Predicts Zinc and Copper Can Be Repurposed as Endometriosis Therapies
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  39. Diagnostic Prediction of Progressive Atherosclerosis in High-Fat Meal Consumers and Their Common Pathological Mechanisms
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  40. Additional file 1 of PALMER: improving pathway annotation based on the biomedical literature mining with a constrained latent block model
    Nam, Jin Hyun, Couch, Daniel, Willian A. da Silveira, Yu, Zhenning, Dongjun Chung · 2020 · Figshare
  41. Additional file 2 of Lung disease network reveals impact of comorbidity on SARS-CoV-2 infection and opportunities of drug repurposing
    Asim Bikas Das · 2021 · Figshare
  42. Additional file 7 of Golden bile powder prevents drunkenness and alcohol-induced liver injury in mice via the gut microbiota and metabolic modulation
    Wang, Yarong, Zou, Zhenzhuang, Wang, Sihua, Airong Ren, Zhaolin Ding, Li, Yingying, Wang, Yifang, Qian, Zhengming, Bian, Baolin, Huang, Bo et al. · 2024 · Figshare
  43. Additional file 1 of Task-driven knowledge graph filtering improves prioritizing drugs for repurposing
    Florin Ratajczak, Mitchell Joblin, Martin Ringsquandl, Marcel E. Hildebrandt · 2022 · Figshare
  44. Additional file 2 of Golden bile powder prevents drunkenness and alcohol-induced liver injury in mice via the gut microbiota and metabolic modulation
    Wang, Yarong, Zou, Zhenzhuang, Wang, Sihua, Airong Ren, Zhaolin Ding, Li, Yingying, Wang, Yifang, Qian, Zhengming, Bian, Baolin, Huang, Bo et al. · 2024 · Figshare
  45. Additional file 5 of Lung disease network reveals impact of comorbidity on SARS-CoV-2 infection and opportunities of drug repurposing
    Asim Bikas Das · 2021 · Figshare
  46. Additional file 1 of Golden bile powder prevents drunkenness and alcohol-induced liver injury in mice via the gut microbiota and metabolic modulation
    Wang, Yarong, Zou, Zhenzhuang, Wang, Sihua, Airong Ren, Zhaolin Ding, Li, Yingying, Wang, Yifang, Qian, Zhengming, Bian, Baolin, Huang, Bo et al. · 2024 · Figshare
  47. Additional file 6 of Lung disease network reveals impact of comorbidity on SARS-CoV-2 infection and opportunities of drug repurposing
    Asim Bikas Das · 2021 · Figshare
  48. Additional file 5 of Integrating animal experiments, mass spectrometry and network-based approach to reveal the sleep-improving effects of Ziziphi Spinosae Semen and γ-aminobutyric acid mixture
    Airong Ren, Tingbiao Wu, Wang, Yarong, Qing Fan, Zhenhao Yang, Zhang, Shixun, Cao, Yongjun, Cui, Guozhen · 2024 · Figshare
  49. Additional file 3 of Task-driven knowledge graph filtering improves prioritizing drugs for repurposing
    Florin Ratajczak, Mitchell Joblin, Martin Ringsquandl, Marcel E. Hildebrandt · 2022 · Figshare
  50. Additional file 6 of scDrugPrio: a framework for the analysis of single-cell transcriptomics to address multiple problems in precision medicine in immune-mediated inflammatory diseases
    Samuel Schäfer, Smelik, Martin, Oleg Sysoev, Zhao, Yelin, Desiré Eklund, Sandra Lilja, Mika Gustafsson, Heyn, Holger, Julia, Antonio, Kovács, István A. et al. · 2024 · Figshare
  51. Additional file 4 of Golden bile powder prevents drunkenness and alcohol-induced liver injury in mice via the gut microbiota and metabolic modulation
    Wang, Yarong, Zou, Zhenzhuang, Wang, Sihua, Airong Ren, Zhaolin Ding, Li, Yingying, Wang, Yifang, Qian, Zhengming, Bian, Baolin, Huang, Bo et al. · 2024 · Figshare
  52. Additional file 2 of Network proximity analysis as a theoretical model for identifying potential novel therapies in primary sclerosing cholangitis
    Jessica Leighton, Jones, David E. J., Jessica Katharine Dyson, Cordell, Heather J. · 2024 · Figshare
  53. Additional file 2 of scDrugPrio: a framework for the analysis of single-cell transcriptomics to address multiple problems in precision medicine in immune-mediated inflammatory diseases
    Samuel Schäfer, Smelik, Martin, Oleg Sysoev, Zhao, Yelin, Desiré Eklund, Sandra Lilja, Mika Gustafsson, Heyn, Holger, Julia, Antonio, István A. Kovács et al. · 2024 · Figshare
  54. Additional file 1 of Integrating animal experiments, mass spectrometry and network-based approach to reveal the sleep-improving effects of Ziziphi Spinosae Semen and γ-aminobutyric acid mixture
    Airong Ren, Tingbiao Wu, Wang, Yarong, Qing Fan, Zhenhao Yang, Zhang, Shixun, Cao, Yongjun, Cui, Guozhen · 2024 · Figshare
  55. Additional file 3 of Integrating animal experiments, mass spectrometry and network-based approach to reveal the sleep-improving effects of Ziziphi Spinosae Semen and γ-aminobutyric acid mixture
    Airong Ren, Tingbiao Wu, Wang, Yarong, Qing Fan, Zhenhao Yang, Zhang, Shixun, Cao, Yongjun, Cui, Guozhen · 2024 · Figshare
  56. Additional file 4 of Lung disease network reveals impact of comorbidity on SARS-CoV-2 infection and opportunities of drug repurposing
    Asim Bikas Das · 2021 · Figshare
  57. Additional file 3 of scDrugPrio: a framework for the analysis of single-cell transcriptomics to address multiple problems in precision medicine in immune-mediated inflammatory diseases
    Samuel Schäfer, Smelik, Martin, Oleg Sysoev, Zhao, Yelin, Desiré Eklund, Sandra Lilja, Mika Gustafsson, Heyn, Holger, Julia, Antonio, Kovács, István A. et al. · 2024 · Figshare
  58. Additional file 4 of scDrugPrio: a framework for the analysis of single-cell transcriptomics to address multiple problems in precision medicine in immune-mediated inflammatory diseases
    Samuel Schäfer, Smelik, Martin, Oleg Sysoev, Zhao, Yelin, Desiré Eklund, Sandra Lilja, Mika Gustafsson, Heyn, Holger, Julia, Antonio, Kovács, István A. et al. · 2024 · Figshare
  59. Additional file 3 of Network proximity analysis as a theoretical model for identifying potential novel therapies in primary sclerosing cholangitis
    Jessica Leighton, Jones, David E. J., Jessica Katharine Dyson, Cordell, Heather J. · 2024 · Figshare
  60. Additional file 1 of Functional module detection through integration of single-cell RNA sequencing data with protein–protein interaction networks
    Florian Klimm, Toledo, Enrique M., Monfeuga, Thomas, Zhang, Fang, Deane, Charlotte M., Reinert, Gesine · 2020 · Figshare
  61. Additional file 5 of Golden bile powder prevents drunkenness and alcohol-induced liver injury in mice via the gut microbiota and metabolic modulation
    Wang, Yarong, Zou, Zhenzhuang, Wang, Sihua, Airong Ren, Zhaolin Ding, Li, Yingying, Wang, Yifang, Qian, Zhengming, Bian, Baolin, Huang, Bo et al. · 2024 · Figshare
  62. Additional file 1 of scDrugPrio: a framework for the analysis of single-cell transcriptomics to address multiple problems in precision medicine in immune-mediated inflammatory diseases
    Samuel Schäfer, Smelik, Martin, Oleg Sysoev, Zhao, Yelin, Desiré Eklund, Sandra Lilja, Mika Gustafsson, Heyn, Holger, Julia, Antonio, István A. Kovács et al. · 2024 · Figshare
  63. Additional file 5 of scDrugPrio: a framework for the analysis of single-cell transcriptomics to address multiple problems in precision medicine in immune-mediated inflammatory diseases
    Samuel Schäfer, Smelik, Martin, Oleg Sysoev, Zhao, Yelin, Desiré Eklund, Sandra Lilja, Mika Gustafsson, Heyn, Holger, Julia, Antonio, István A. Kovács et al. · 2024 · Figshare
  64. Additional file 2 of Integrating animal experiments, mass spectrometry and network-based approach to reveal the sleep-improving effects of Ziziphi Spinosae Semen and γ-aminobutyric acid mixture
    Airong Ren, Tingbiao Wu, Wang, Yarong, Qing Fan, Zhenhao Yang, Zhang, Shixun, Cao, Yongjun, Cui, Guozhen · 2024 · Figshare
  65. Additional file 2 of Task-driven knowledge graph filtering improves prioritizing drugs for repurposing
    Florin Ratajczak, Mitchell Joblin, Martin Ringsquandl, Marcel E. Hildebrandt · 2022 · Figshare
  66. Additional file 7 of Lung disease network reveals impact of comorbidity on SARS-CoV-2 infection and opportunities of drug repurposing
    Asim Bikas Das · 2021 · Figshare
  67. Additional file 6 of Golden bile powder prevents drunkenness and alcohol-induced liver injury in mice via the gut microbiota and metabolic modulation
    Wang, Yarong, Zou, Zhenzhuang, Wang, Sihua, Airong Ren, Zhaolin Ding, Li, Yingying, Wang, Yifang, Qian, Zhengming, Bian, Baolin, Huang, Bo et al. · 2024 · Figshare
  68. Additional file 7 of scDrugPrio: a framework for the analysis of single-cell transcriptomics to address multiple problems in precision medicine in immune-mediated inflammatory diseases
    Samuel Schäfer, Smelik, Martin, Oleg Sysoev, Zhao, Yelin, Desiré Eklund, Sandra Lilja, Mika Gustafsson, Heyn, Holger, Julia, Antonio, Kovács, István A. et al. · 2024 · Figshare
  69. Additional file 1 of Lung disease network reveals impact of comorbidity on SARS-CoV-2 infection and opportunities of drug repurposing
    Asim Bikas Das · 2021 · Figshare
  70. Additional file 8 of Lung disease network reveals impact of comorbidity on SARS-CoV-2 infection and opportunities of drug repurposing
    Asim Bikas Das · 2021 · Figshare
  71. Additional file 3 of Lung disease network reveals impact of comorbidity on SARS-CoV-2 infection and opportunities of drug repurposing
    Asim Bikas Das · 2021 · Figshare
  72. Additional file 10 of Lung disease network reveals impact of comorbidity on SARS-CoV-2 infection and opportunities of drug repurposing
    Asim Bikas Das · 2021 · Figshare
  73. Additional file 3 of Golden bile powder prevents drunkenness and alcohol-induced liver injury in mice via the gut microbiota and metabolic modulation
    Wang, Yarong, Zou, Zhenzhuang, Wang, Sihua, Airong Ren, Zhaolin Ding, Li, Yingying, Wang, Yifang, Qian, Zhengming, Bian, Baolin, Huang, Bo et al. · 2024 · Figshare
  74. Additional file 4 of Integrating animal experiments, mass spectrometry and network-based approach to reveal the sleep-improving effects of Ziziphi Spinosae Semen and γ-aminobutyric acid mixture
    Airong Ren, Tingbiao Wu, Wang, Yarong, Qing Fan, Zhenhao Yang, Zhang, Shixun, Cao, Yongjun, Cui, Guozhen · 2024 · Figshare
  75. Additional file 9 of Lung disease network reveals impact of comorbidity on SARS-CoV-2 infection and opportunities of drug repurposing
    Asim Bikas Das · 2021 · Figshare
  76. Additional file 1 of Network proximity analysis as a theoretical model for identifying potential novel therapies in primary sclerosing cholangitis
    Jessica Leighton, Jones, David E. J., Jessica Katharine Dyson, Cordell, Heather J. · 2024 · Figshare
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