Network-based in silico drug efficacy screening

Guney, Emre, Menche, Jörg, Vidal, Marc, Barábasi, Albert-László·2016·Nature Communications
DOI 10.1038/ncomms10331

Cited by (643)

Items 601–643 of 643

  1. Artificial Intelligence-Driven Construction of Predictive and Druggable Frameworks to an In Silico Bioengineering Evidence Support for Therapy of Esophageal Squamous Cell Carcinoma Patients: Insights from a Toll-like Receptor Signal with Th17 and T Helper Microenvironment
    Bo Liu, Jiazhou Xiao, Xuan Tao, Xu Li · 2026 · Bioengineering
  2. Role of Artificial Intelligence (AI) Enabled Tools in Healthcare and Drug Discovery Process: A Narrative Review
    Vipul Dhanjibhai Prajapati · 2026 · Apollo Medicine
  3. A Hypoxia-Apoptosis Stress-Adaptation State Defines Immune-Low Melanoma and Predicts Metastatic Risk
    Saige Yin, Dan Xu · 2026 · Cancers
  4. Computational Pipelines for Disease-Specific Drug Repurposing
    Mena Abdelsayed · 2026 · Pharmaceutical science.
  5. Multi-omics mechanistic investigation of Yograj Guggulu, an Ayurvedic polyherbal formulation, against MIA-induced osteoarthritis in rats
    Amay Sanjay Redkar, Arun Surendran, Bishal Rajdev, Neethu Prasad, Arun N. Prakash, Dikshita Hazarika, Ilackkeya Bhavananthi, Naveen Kumar, Gajji Babu, Y. R. Sanjaya Kumar et al. · 2026 · Journal of Ethnopharmacology
  6. Network-based analysis identifies shared mechanisms between ischemic stroke and myocardial infarction and therapeutic ingredients of Buyang Huanwu Decoction
    Shuaixin Zhang, Yue Lin, Wenke Xiao, Wei Chen, Sanyin Zhang · 2026 · Frontiers in Genetics
  7. Integrated Bioinformatics and Explainable Machine Learning Analyses Reveal Mesenchymal Stem Cell Exosome-Related Biomarkers for Diabetic Retinopathy
    Liu Zheng, Jiaojiao Jiang, Jinqing Li, Xingyu Su, Shixiong Peng, Zhixiang DING · 2026 · Journal of Ocular Pharmacology and Therapeutics
  8. Network-based prediction of drug combinations with quantum annealing
    Diogo Ramos, Bruno Coelho Coutinho, Duarte Magano · 2026 · Quantum Machine Intelligence
  9. Drug repurposing using docking approaches
    Disha Roy, Manoj Kumar Jana, Suryaprakash Tripathy, Deepesh Joshi, Piyal Mukherjee, Dipti Yadav, Sahar Qazi, Sayantam Jana, Sudip Das, Neeraj Mohan Gupta · 2026 · Elsevier eBooks
  10. Peroxisomal interactome mapping enables network-based modelling of function and disease
    Søren W. Gersting, Julia V Cramer, Philipp Guder, Amelie Sophia Lotz-Havla, Barbara Wolf, Heidi Noll‐Puchta, Ralf Erdmann, Ania Carolina Muntau, Mathias Woidy · 2026 · Life Science Alliance
  11. Network-based machine learning to identify biomarkers for systemic lupus erythematosus
    Minhyuk Park, Donghyo Kim, Juhun Lee, Jaegyun Noh, Chan Johng Kim, Youngchul Oh, C S Suh, Ji-Won Kim, Sin‐Hyeog Im, Sanguk Kim et al. · 2026 · BMC Biology
  12. Context-Aware Multilevel Classification of Semantic Relations in Drug-Adverse Drug Reaction (ADR) Networks–Predicting Drug-Induced Liver Injury (DILI) as a Case Study
    Rein Vos, Erik M. van Mulligen, Jan A. Kors · 2026 · Chemical Research in Toxicology
  13. Stepwise multifunctional metal-polyphenol nanomodulator for sequential antibacterial, anti-inflammatory, and anti-DIC therapy in sepsis
    Yancen Li, Guang Xin, Chengyu Wan, Tao Wang, Qilong Zhou, Zeliang Wei, Tingyu Wen, W Q Huang · 2026 · Chemical Engineering Journal
  14. A Hybrid Graph-Based Framework for Synergistic Drug Combination Discovery and Polypharmacy Side Effect Risk Profiling
    B Vishnu Vardhan, E Shelian Gladis, Ch Sri Lakshmi Meghana, G Lakshmi Priyanka · 2026 · International Conference on Cognitive Computing and Networking Systems (ICC-CNS)
  15. AI-Driven Drug Repurposing Strategies for Precision Therapy in Breast Cancer
    Bharath Kumar Jakkula, Perugu Shyam · 2026 · Pharmaceutical science.
  16. A Network Medicine Framework Identifies Dihydroisotanshinone I as a SKP2-Targeting Anti-Breast Cancer Agent with Potent Activity in Triple-Negative Breast Cancer
    Sai-Sai Tian, Jinyuan Lu, Chengyang Guo, Wenjing Gu, Pengli Huang, Xi-Ke Xu, Qun Wang, Wei-Dong Zhang · 2026 · Engineering
  17. Proteome-Level Autophagy–Lysosome Remodelling Marks Ageing in Human Dermal Fibroblasts and Nominates Hydroxytyrosol as a Candidate Nutraceutical
    Meng Cai, Meihong Xu · 2026 · International Journal of Molecular Sciences
  18. AI-based strategies for diagnosis and therapeutic discovery in pulmonary fibrosis
    Yue Lin, Qianqian Liu, Xiang-Yi Lei, Hui-Yu Cao, Peng-Mian Feng, Yue-Mei Wang, Dan Sun, Guang Xin, Sanyin Zhang, Wei Chen · 2026 · Chinese Herbal Medicines
  19. Deciphering the polypharmacology of a traditional Chinese formula for MASLD: Network proximity to identifying Akt-modulating active ingredients
    Zhongyu Zhang, Min Wang, Wenkui Yang, Shuang Li, Yuanyuan Cai, Jiajia Chen, Xuewen Chen, Minhua Gu, Yong Gu · 2026 · Journal of Ethnopharmacology
  20. Using Biological Networks to Guide Biomedical Prediction
    Xiaoyu Zhao, JungHo Kong, Karen Pu, Christopher Churas, Jillian A. Parker, Trey E. Ideker · 2026 · Methods in molecular biology
  21. Integrative multi-omics and network biology in cardiovascular disease: a systems-level framework for translational discovery
    Vanesa Brecher, Vasiliki A. Androutsopoulou, Serge Sicouri, Basel Ramlawi, Dimitrios V. Avgerinos, Thanos Athanasiou, Dimitrios E. Magouliotis · 2026 · Frontiers in Systems Biology
  22. GraphPert: A graph autoencoder framework for network-based drug repurposing using transcriptional signatures—A case study on melanoma
    Germán Andrés Conti, José Leonardo Gómez Chávez, Ernesto Rafael Pérez, Emilio Angelina · 2026 · Computers in Biology and Medicine
  23. Leveraging neural network models for drug repurposing: a case study on cardiac hypertrophy
    Rasmus Magnusson, Markus Johansson, Sepideh Hagvall, Jane Synnergren · 2026 · Scientific Reports
  24. A novel multiomics machine learning signature identifies rapid progression in clinically low risk prostate cancer
    Alexandra Rafeletou, Faezeh Fathi, Tatjana Kiseļova, Golnaz Taheri, Arian Lundberg · 2026 · npj Digital Medicine
  25. Mechanism-aware and safety-validated AI for drug repurposing: a critical review and translational pharmacology framework
    Moumita Hazra, Harishchander Anandaram · 2026 · Frontiers in Pharmacology
  26. BRIDGE-AD reveals Alzheimer’s disease effectors through interpretable large-scale omics integration
    Greta Baltušytė, Jonas Cerneckis, Harry Convey, Guoqiang Sun, Zyrille C. E. Abela, Miguel Ramirez, Daniel Wang, Guihua Sun, Tao Zhou, David R. Spring et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  27. Clinical Efficacy and Mechanisms of ZiyuShuang , an Anti‐Skin Aging Formula Identified Through Network Medicine Framework Analysis
    Yingpeng Tong, 倪香梅, Xuanqi Jiang, Ru Zhang, Pengcheng Guo, Chunbo Feng, Jianxin Wang · 2026 · Journal of Cosmetic Dermatology
  28. A Drug-Referenced Machine-Learning Framework for Prioritizing Korean Herbal Formulations in Hypertension Using Linear SVM and Graph Convolutional Networks
    Dong‐Woo Lim · 2026 · International Journal of Molecular Sciences
  29. Targeting senescence-associated fibrotic signatures identifies syringin as an effective modulator of the ATR/CHK1–p53 axis in idiopathic pulmonary fibrosis
    Yuyang Wang, Guanghui Yin, Mixing Niu, Wei Wang, Zhenyun Liao, Lei Yang, 吴春莉, Yu Cao, Kai Gao, Zhaoxing Dong · 2026 · Chinese Journal of Natural Medicines
  30. MoBC-Net: computing network inter-module distance and module-based betweenness centrality
    Hyekyoung Lee, Hanbi Lee, Yoomi Baek, Ahyoung Choi, Hyunjin Shin · 2026 · Bioinformatics Advances
  31. Drug Repurposing in Cancer Therapy: A Review of Therapeutic Potential Across Diverse Drug Classes
    Vivek Yadav, Viralkumar B. Mandaliya, Umang Shah · 2026 · ChemistrySelect
  32. Network-Based Characterization of Synergistic Drug Combinations in Alzheimer's Disease
    Andrea Álvarez-Pérez, Lucía Prieto Santamaría, Belén Ríos‐Sánchez, Alejandro Rodríguez‐González · 2026 · Proceedings - IEEE Symposium on Computer-Based Medical Systems
  33. Drug Repositioning Through Interpretable Link Prediction in Drug–Disease Networks
    Wagner Luiz da Cunha Ceulin, Rui Carlos Camacho, José Costa Pereira, Inês Dutra · 2026 · Lecture notes in computer science
  34. Malignant and stromal partial EMT programmes and cetuximab outcome in head and neck cancer
    Dania Zuhier Ragheb Alkhatib, Sophia Lunetto, Priyanka Chakraborty, Mohit Kumar Jolly, Michael P. Philpott, Adrian Biddle, Gehad Youssef, Namshik Han · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  35. Interventional Effects and Neurometabolic Regulation of a Panax quinquefolius-Containing Herbal Extract (JYF) in Diazepam Withdrawal Syndrome in Mice
    Yue Jiao, Chang Gao, Peng Li, 刘艳骄, Xiaoliang Zhao, Yang Liu, Zhiguo Wang, Yinglan Nie, Tao Li · 2026 · Pharmaceuticals
  36. Deciphering isonicotinylation and mast cell-associated pathogenic patterns in Duchenne muscular dystrophy: evidence from ensemble learning-driven multi-omics and in vitro validation
    Sunrui Yu, Duojia Xu, Yuting Hua, Hangfeng Mo, Yujin Liu · 2026 · Frontiers in Molecular Biosciences
  37. Artificial intelligence (AI)‐enabled RNA therapeutic design: from molecular optimization to system‐level evaluation
    Yongtian Wang, Jiaqi Wu · 2026 · British Journal of Pharmacology
  38. In Vivo Transcriptomics-Based Framework for Systematic Indication Expansion
    Zsolt Palmer, Shubham Koirala, Nabasmita Talukdar, Xiaodan Zhang, Hannah S. Garver, McKenzie Mahlmeister, Li Huang, Dimitri Joseph, Dmitry R. Leshchiner, Rama Shankar et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  39. Topology-adjusted knockout (TAKO): interpretable in silico single-gene knockout ranking on wild-type single-cell gene regulatory networks
    Hao Wang, Koji Oba · 2026 · Frontiers in Bioinformatics
  40. Physicochemical, Predicted ADME, and Structural Positioning of Azelaic Acid Within an Endocrine Oncology Reference Framework
    Elena-Daniela Jurj, Adrian Voicu, Daiana Colibăşanu, Mirela Voicu, Mirela F. Nicolov, Lucreția Udrescu · 2026 · Pharmaceuticals
  41. AI-Driven Drug Repurposing for Multidrug-Resistant Infections: Computational Rigor, Translational Realities, and Strategic Future Directions
    Kingsley Chukwuka Amaihunwa, Daniel Kelechi Egbule, Augustina Oghenevwaerhe Jewo, Felix Oghenemaro Enwa · 2026 · Acta Microbiologica Hellenica
  42. Can autonomous Agentic-AI systems accelerate drug discovery and development in the next decade?
    Navaneet Chaturvedi, Shafiul Haque, Vijay Kumar · 2026 · Briefings in Bioinformatics
  43. AI-enabled drug repurposing in Alzheimer’s disease: from computational nomination to pharmacological proof
    Xinzhong Li, Illana Gozes · 2026 · Frontiers in Pharmacology