The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Early ERK1/2 activation promotes DRP1-dependent mitochondrial fission necessary for cell reprogramming
Open accessAbstract
During the process of reprogramming to induced pluripotent stem (iPS) cells, somatic cells switch from oxidative to glycolytic metabolism, a transition associated with profound mitochondrial reorganization. Neither the importance of mitochondrial remodelling for cell reprogramming, nor the molecular mechanisms controlling this process are well understood. Here, we show that an early wave of mitochondrial fragmentation occurs upon expression of reprogramming factors. Reprogramming-induced mitochondrial fission is associated with a minor decrease in mitochondrial mass but not with mitophagy. The pro-fission factor Drp1 is phosphorylated early in reprogramming, and its knockdown and inhibition impairs both mitochondrial fragmentation and generation of iPS cell colonies. Drp1 phosphorylation depends on Erk activation in early reprogramming, which occurs, at least in part, due to downregulation of the MAP kinase phosphatase Dusp6. Taken together, our data indicate that mitochondrial fission controlled by an Erk-Drp1 axis constitutes an early and necessary step in the reprogramming process to pluripotency.
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ERK signalling: A master regulator of cell behaviour, life and fate
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RAF-MEK-ERK pathway in cancer evolution and treatment
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Function and regulation of the divisome for mitochondrial fission
Kraus, F., Roy, K., Pucadyil, T. J., & Ryan, M. T. (2021) · Nature · doi:10.1038/s41586-021-03214-x · Cited by 445
Quality control of the mitochondrion
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Metadata
- Authors
- Prieto, J., León, M., Ponsoda, X., Sendra, R., Bort, R., Ferrer-Lorente, R., Raya, A., López-García, C., & Torres, J.
- Venue
- Nature Communications
- Published
- 2016-03-31
- Volume
- 7
- Issue
- 1
- Pages
- 11124-11124
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2334626778
- Cited by
- 273
- References
- 15
- FWCI
- 12.94
- Type
- journal article
- Language
- en
- Open access
- gold
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- Prieto, J., León, M., Ponsoda, X., Sendra, R., Bort, R., Ferrer-Lorente, R., Raya, A., López-García, C., & Torres, J. (2016). Early ERK1/2 activation promotes DRP1-dependent mitochondrial fission necessary for cell reprogramming. Nature Communications. https://doi.org/10.1038/ncomms11124
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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