Ubiqutination via K27 and K29 chains signals aggregation and neuronal protection of LRRK2 by WSB1

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GTP‐binding inhibitors increase LRRK2‐linked ubiquitination and Lewy body‐like inclusions

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Regulation of LRRK2 mRNA stability by ATIC and its substrate AICAR through ARE‐mediated mRNA decay in Parkinson's disease

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Identification of Histone Acetylation Modification Sites in the Striatum of Subchronically Manganese-Exposed Rats

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WSB1/2 target chromatin-bound lysine-methylated RelA for proteasomal degradation and NF-κB termination

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Posttranslational modification of Aurora A‐NSD2 loop contributes to drug resistance in t(4;14) multiple myeloma

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FOXK2 targeting by the SCF-E3 ligase subunit FBXO24 for ubiquitin mediated degradation modulates mitochondrial respiration

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Protein aggregation identified in olfactory neuronal cells is associated with cognitive impairments in a subset of living schizophrenia patients

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In Vivo Visual Screen for Dopaminergic Rab ↔ LRRK2-G2019S Interactions in Drosophila Discriminates Rab10 from Rab3

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Neuronal death signaling pathways triggered by mutant LRRK2

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WSB1, as an E3 ligase, restrains myocardial ischemia–reperfusion injury by activating β-catenin signaling via promoting GSK3β ubiquitination

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RNF20 contributes to epigenetic immunosuppression through CDK9-dependent LSD1 stabilization

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The parkinsonism-associated protein FBXO7 cooperates with the BAG6 complex in proteasome function and controls the subcellular localization of the complex

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Proteome solubility is differentially reshaped by thermal stress and regulators of ubiquitination

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Role of Genes and Treatments for Parkinson’s Disease

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An Expert-guided Hierarchical Graph Attention Network for Post-traumatic Stress Disorder Highly-associative Genetic Biomarkers IdentificationPreprint

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K11- and K29-ubiquitination-mediated nuclear translocation of glycolytic enzyme aldolase A promotes pancreatic cancer progression by NF-κB activation

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Ubiquitination status does not affect Vps34 degradation

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The ubiquitin-conjugating enzyme UBE2D/eff maintains a youthful proteome and ensures protein quality control during agingPreprint

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Paired copy number variation analysis in siblings discordant for familial Parkinson’s disease

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Decode the Ubiquitinome in Parkinson’s Disease: From Pathological Aggregates to Targeted DUB Therapeutics

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UBA1 knockdown dysregulates UBA1-sensitive proteins and impairs muscle function in models of spinal muscular atrophy X-linked 2

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Machine Learning Analysis of Genomic Factors Influencing Hyperbaric Oxygen Therapy in Parkinson’s Disease

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Identification of Putative LRRK2 Inhibitors in the Pathogensis of Parkinson's Disease: A Drug-Repurposing Approach

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The ubiquitin-conjugating enzyme UBE2D/eff maintains a youthful proteome and ensures protein quality control during agingPreprint

Hunt, L. C., Nyamkondiwa, K., Stephan, A., Jiao, J., Kavdia, K., Pagala, V., Peng, J., & Demontis, F. (2024) · eLife · doi:10.7554/elife.94739.1 · Cited by 2 · see citing works

SFXN2 contributes mitochondrial dysfunction-induced apoptosis as a substrate of Parkin

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The Crosstalk Between CRL5 and APC/C E3 Ligases Regulates Metastasis and Chemosensitivity of Cancer Cells

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TRIM21 facilitates inflammasome assembly and contributes to autoinflammatory disease

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Conformation-specific Antibody Deciphers K27-linked Ubiquitination in Chaperone-Mediated ProteostasisPreprint

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RNF114 suppresses tumour metastasis through the regulation of PARP10Preprint

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USP39-mediated deubiquitination of Cyclin B1 at Lys242 promotes tumor cell cycle G2/M transition and glioma progressionPreprint

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The ubiquitin-conjugating enzyme UBE2D/eff maintains a youthful proteome and ensures protein quality control during agingPreprint

Hunt, L. C., Nyamkondiwa, K., Stephan, A., Jiao, J., Kavdia, K., Pagala, V., Peng, J., & Demontis, F. (2024) · eLife · doi:10.7554/elife.94739

Author response: The ubiquitin-conjugating enzyme UBE2D/eff maintains a youthful proteome and ensures protein quality control during aging

Hunt, L. C., Nyamkondiwa, K., Stephan, A., Jiao, J., Kavdia, K., Pagala, V., Peng, J., & Demontis, F. (2024) · eLife · doi:10.7554/elife.94739.2.sa4

eLife Assessment: The ubiquitin-conjugating enzyme UBE2D/eff maintains a youthful proteome and ensures protein quality control during aging

Wappner, P. (2024) · eLife · doi:10.7554/elife.94739.2.sa3

The ubiquitin-conjugating enzyme UBE2D/eff maintains a youthful proteome and ensures protein quality control during agingPreprint

Hunt, L. C., Nyamkondiwa, K., Stephan, A., Jiao, J., Kavdia, K., Pagala, V., Peng, J., & Demontis, F. (2024) · eLife · doi:10.7554/elife.94739.2

Reviewer #1 (Public Review): The ubiquitin-conjugating enzyme UBE2D/eff maintains a youthful proteome and ensures protein quality control during aging

(2024) · eLife · doi:10.7554/elife.94739.2.sa2

Reviewer #2 (Public Review): The ubiquitin-conjugating enzyme UBE2D/eff maintains a youthful proteome and ensures protein quality control during aging

(2024) · eLife · doi:10.7554/elife.94739.2.sa1

Reviewer #3 (Public Review): The ubiquitin-conjugating enzyme UBE2D/eff maintains a youthful proteome and ensures protein quality control during aging

(2024) · eLife · doi:10.7554/elife.94739.2.sa0

Parkin, a key player in Parkinson's disease pathogenesis: A review

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Additional file 1 of WSB1, as an E3 ligase, restrains myocardial ischemia–reperfusion injury by activating β-catenin signaling via promoting GSK3β ubiquitination

Fang, L., Tao, Y., Che, G., Yun, Y., Ren, M., & Liu, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26685105

Ubiquitylation of DNA polymerase β via atypical K27 chains signals a DNA damage response

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GTP‐binding inhibitors increase LRRK2‐linked ubiquitination and Lewy body‐like inclusions

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Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration

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Polyubiquitin-Proteasomal Degradation of Leucine-Rich Repeat Kinase 2 Wildtype and G2019S

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Novel E3 Ubiquitin Ligase Regulators of Parkinson's Protein LRRK2

Stormo, A. E. D. (2020) · eScholarship (California Digital Library)

A proteomic analysis of LRRK2 binding partners reveals interactions with multiple signaling components of the WNT/PCP pathway

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