PTEN regulates EG5 to control spindle architecture and chromosome congression during mitosis

In-gel digestion for mass spectrometric characterization of proteins and proteomes

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A mechanism linking extra centrosomes to chromosomal instability

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PTEN and the PI3-Kinase Pathway in Cancer

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Essential role for nuclear PTEN in maintaining chromosomal integrity

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Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo

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Acetylation Is Indispensable for p53 Activation

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A standardized kinesin nomenclature

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Ubiquitination regulates PTEN nuclear import and tumor suppression

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NEDD4-1 Is a Proto-Oncogenic Ubiquitin Ligase for PTEN

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The bipolar mitotic kinesin Eg5 moves on both microtubules that it crosslinks

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Mitotic spindle organization by a plus-end-directed microtubule motor

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Microtubule motors in mitosis

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Mutation of a gene that encodes a kinesin-like protein blocks nuclear division in A. nidulans

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Two Saccharomyces cerevisiae kinesin-related gene products required for mitotic spindle assembly.

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PTEN: a new guardian of the genome

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Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers

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Nuclear PTEN Regulates the APC-CDH1 Tumor-Suppressive Complex in a Phosphatase-Independent Manner

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Mechanisms of Mitotic Spindle Assembly and Function

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Lack of PTEN sequesters CHK1 and initiates genetic instability

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The Bipolar Kinesin, KLP61F, Cross-links Microtubules within Interpolar Microtubule Bundles of Drosophila Embryonic Mitotic Spindles

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Force and Length in the Mitotic Spindle

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Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formation

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The Xenopus laevis aurora-related protein kinase pEg2 associates with and phosphorylates the kinesin-related protein XlEg5

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The tumor suppressor PTEN has a critical role in antiviral innate immunity

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Mitotic functions of kinesin-5

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Chromosome Congression by Kinesin-5 Motor-Mediated Disassembly of Longer Kinetochore Microtubules

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The NIMA-family kinase Nek6 phosphorylates the kinesin Eg5 at a novel site necessary for mitotic spindle formation

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Phosphorylation by p34cdc2 Protein Kinase Regulates Binding of the Kinesin-related Motor HsEg5 to the Dynactin Subunit p150Glued

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CREB Is a Novel Nuclear Target of PTEN Phosphatase

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The molecular cloning and identification of a gene product specifically required for nuclear movement in Aspergillus nidulans.

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Cell Cycle-dependent Dynamics and Regulation of Mitotic Kinesins in Drosophila S2 Cells

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PTEN Interacts with Histone H1 and Controls Chromatin Condensation

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PTEN Protein Phosphatase Activity Correlates with Control of Gene Expression and Invasion, a Tumor-Suppressing Phenotype, But Not with AKT Activity

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Phosphorylation by Cdk1 Increases the Binding of Eg5 to Microtubules In Vitro and in Xenopus Egg Extract Spindles

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PTEN C-Terminal Deletion Causes Genomic Instability and Tumor Development

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PTEN regulates DNA replication progression and stalled fork recovery

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Suppression of leukemia development caused by PTEN loss

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Transient defects of mitotic spindle geometry and chromosome segregation errors

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Phospho-regulation of kinesin-5 during anaphase spindle elongation

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Mutations in the bimC box of Cut7 indicate divergence of regulation within the bimC family of kinesin related proteins

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Protein expression and cellular localization in two prognostic subgroups of diffuse large B-cell lymphoma: Higher expression of ZAP70 and PKC-β II in the non-germinal center group and poor survival in patients deficient in nuclear PTEN

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How Mitotic Errors Contribute to Karyotypic Diversity in Cancer

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B-Cyclin/CDKs Regulate Mitotic Spindle Assembly by Phosphorylating Kinesins-5 in Budding Yeast

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PTEN stabilizes TOP2A and regulates the DNA decatenation

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Tissue Proteomics by One-Dimensional Gel Electrophoresis Combined with Label-Free Protein Quantification

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Highly specific capture and direct MALDI-MS analysis of phosphorylated peptides using novel multifunctional chitosan-GMA-IDA-Fe (III) nanosphere

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Genome maintenance in the context of 4D chromatin condensation

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Walking, hopping, diffusing and braking modes of kinesin-5

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Mechanisms of Chromosome Congression during Mitosis

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Kinesin-5 Regulation and Function in Mitosis

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Cell Cycle Control by PTEN

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Permeabilizing Cell Membranes with Electric Fields

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PTEN Nuclear FunctionsPreprint

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PTEN Regulates Glucose Transporter Recycling by Impairing SNX27 Retromer Assembly

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PTEN in the maintenance of genome integrity: From DNA replication to chromosome segregation

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The Mechanisms of lncRNA-Mediated Multidrug Resistance and the Clinical Application Prospects of lncRNAs in Breast Cancer

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Recurrent Glioblastoma—Molecular Underpinnings and Evolving Treatment Paradigms

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Mitotic Functions and Characters of KIF11 in Cancers

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PTEN mutations predict benefit from tumor treating fields (TTFields) therapy in patients with recurrent glioblastoma

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Kinesin Family of Proteins Kif11 and Kif21B Act as Inhibitory Constraints of Excitatory Synaptic Transmission Through Distinct Mechanisms

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PTEN at the interface of immune tolerance and tumor suppression

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PTEN as a Guardian of the Genome: Pathways and TargetsPreprint

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Src family kinase phosphorylation of the motor domain of the human kinesin‐5, Eg5

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Non-canonical function of nuclear PTEN and its implication on tumorigenesis

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Non‐canonical functions of the mitotic kinesin Eg5

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Circulating Tumor Cells in Breast Cancer Patients: A Balancing Act between Stemness, EMT Features and DNA Damage Responses

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The phosphorylation and dephosphorylation switch of VCP/p97 regulates the architecture of centrosome and spindle

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Loss of function of KIF1B impairs oocyte meiotic maturation and early embryonic development in mice

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UHRF1 promotes spindle assembly and chromosome congression by catalyzing EG5 polyubiquitination

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Double Duty: Mitotic Kinesins and Their Post-Mitotic Functions in Neurons

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The Impact of Genetic Variants on PTEN Molecular Functions and Cellular PhenotypesPreprint

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HSP70 regulates Eg5 distribution within the mitotic spindle and modulates the cytotoxicity of Eg5 inhibitors

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PTP-3 phosphatase promotes intramolecular folding of SYD-2 to inactivate kinesin-3 UNC-104 in neurons

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Phosphorylation of XPD drives its mitotic role independently of its DNA repair and transcription functions

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Potential Roles of PTEN on Longevity in Two Closely Related Argopecten Scallops With Distinct Lifespans

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Molecular Motor KIF3B Acts as a Key Regulator of Dendritic Architecture in Cortical Neurons

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The balance of forces generated by kinesins controls spindle polarity and chromosomal heterogeneity in tetraploid cells

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Genome organization during the cell cycle: unity in division

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Computational study of the motor neuron protein KIF5A to identify nsSNPs, bioactive compounds, and its key regulators

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Knockdown of TACC3 inhibits tumor cell proliferation and increases chemosensitivity in pancreatic cancer

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Kinesin Spindle Protein (KIF11) in Mitosis and Cancer

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Nuclear Isoforms of Neurofibromin Are Required for Proper Spindle Organization and Chromosome Segregation

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Luminal A breast cancer resistance mechanisms and emerging treatments

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Polar chromosomes are rescued from missegregation by spindle elongation-driven microtubule pivoting

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Both phosphorylation and phosphatase activity of PTEN are required to prevent replication fork progression during stress by inducing heterochromatin

Misra, S., Chowdhury, S. G., Ghosh, G., Mukherjee, A., & Karmakar, P. (2022) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2022.111800 · Cited by 6 · see citing works

Polar chromosomes are rescued from missegregation by spindle elongation-driven microtubule pivotingPreprint

Koprivec, I., Štimac, V., Đura, M., Vukušić, K., Mikec, P., & Tolić, I. M. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.16.599200 · Cited by 6 · see citing works

CFAP100 couples microtubule glutamylation to spindle pole integrity in keratinocytes to promote epidermal development

Sun, S., Wang, Z., Xu, Z., Wang, Z., Sun, J., Li, K., Liu, M., Zhao, H., Liu, P., & Zhou, J. Y. (2025) · Nature Communications · doi:10.1038/s41467-025-60677-6 · Cited by 4 · see citing works

Deficiency of PTEN leads to aberrant chromosome segregation through downregulation of MAD2

Sun, Z., Lu, J., Wu, M., Li, M., Bai, L., Shi, Z., Hao, L., & Wu, Y. (2019) · Molecular Medicine Reports · doi:10.3892/mmr.2019.10668 · Cited by 4 · see citing works

Multitasking Proteins: Exploring Noncanonical Functions of Proteins during Mitosis.

Piano, V. (2025) · Biochemistry · doi:10.1021/acs.biochem.5c00083 · Cited by 2 · see citing works

PTEN Protein Phosphatase Activity Is Not Required for Tumour Suppression in the Mouse Prostate

Wise, H. M., Harris, A., Kriplani, N., Schofield, A., Caldwell, H., Arends, M. J., Overton, I. M., & Leslie, N. R. (2022) · Biomolecules · doi:10.3390/biom12101511 · Cited by 2 · see citing works

Crosstalk Between Plk1 and PTEN in Mitosis Affects Chromosomal Stability

Li, W., Wang, X., Liu, J., Liu, B., & Hao, Y. (2025) · DNA and Cell Biology · doi:10.1089/dna.2024.0246 · Cited by 2 · see citing works

The role of the kinesin superfamily proteins in the pathogenesis and progression of multiple diseases

Yang, W., Liu, H., Wang, L., & Zhu, Y. (2017) · Chinese Science Bulletin (Chinese Version) · doi:10.1360/n972016-01265 · Cited by 2 · see citing works

Monastrol Targeted KIF11 Showed Potential Treatment Effective of Small Cell Lung CancerPreprint

Wang, X., Jiang, S., Zhou, B., Liu, Z., & Liu, Z. (2019) · doi:10.21203/rs.2.17513/v1 · Cited by 2 · see citing works

Multiple Regulatory Mechanisms of Post-Translational Modifications and Therapeutic Potential of Mitotic Catastrophe

Zhang, Q., Chen, X., Li, S., Cao, L.-Z., Wang, S.-Y., He, Y.-J., Zhang, X., Liu, J., & Liu, X. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27083370 · Cited by 1 · see citing works

Evidence That the Protein Phosphatase Activity of PTEN Contributes to Embryonic Development and Tumor Suppression

Tibarewal, P., Spinelli, L., Kriplani, N., Wise, H. M., Poncet, N., Marzano, G., Anderson, K. E., Grzes, K. M., Varyova, Z., Adil, M., et al. (2026) · Cancer Science · doi:10.1111/cas.70476 · Cited by 1 · see citing works

Two Tails for Neurofibromin: A Tale of Two Microtubule-Associated Proteins

Peta, C., Tsirimonaki, E., Fedonidis, C., Koliou, X., Sakellaridis, N., & Mangoura, D. A. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.97574 · Cited by 1 · see citing works

Unmasking PTEN's nuclear functions

Dai, W. H. (2016) · Cell Cycle · doi:10.1080/15384101.2016.1241606 · Cited by 1 · see citing works

Caracterização do genoma e da resposta imune no microambiente tumoral de neoplasias PTEN-deficientes

Vidotto, T. (2019) · doi:10.11606/t.17.2019.tde-29072019-142549 · Cited by 1 · see citing works

PTP-3(LAR PTPR) promotes intramolecular folding of SYD-2(liprin-α) to inactivate UNC-104(KIF1A) in neuronsPreprint

Shanmugam, M. M., Barmaver, S. N., Huang, H., & Wagner, O. I. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/723288

PTEN: Sumoylation Function is the Key to the Maintenance of Genomic Stability of Cell

Ghosh, G., Misra, S., & Karmakar, P. (2022) · Nano LIFE · doi:10.1142/s1793984422500039

PTEN regulates actin filaments to shape cell cortex architecturePreprint

Ho, K., Patel, S. S., Sullivan, E., Chang, A., Lin, G. H., Lv, M., Fan, X., Naufal, E. R., & Shen, W. H. (2023) · Research Square · doi:10.21203/rs.3.rs-2375922/v1

Comprehensive pan-cancer analysis reveals the importance of SPATS2 in the development of hepatocellular carcinomaPreprint

Ding, J., Li, L., Yu, W., Deng, H., Chen, L., Li, T. F., & Zhang, Y. C. (2023) · Research Square · doi:10.21203/rs.3.rs-2852186/v1

Evidence that the protein phosphatase activity of PTEN contributes to embryonic development and tumour suppression in micePreprint

Tibarewal, P., Spinelli, L., Kriplani, N., Wise, H. M., Poncet, N., Marzano, G., Anderson, K. E., Grzes, K. M., Varyova, Z., Adil, M., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.03.14.711778

PTEN homozygous deletion is a negative prognostic factor in tumor treating fields‐treated glioblastoma, IDH wildtype patients

Nückles, J., Jelgersma, C., Siewert, C., Osberg, B., Schmid, S., Koch, A., Pérez, E., Teichmann, D., Misch, M., Karbe, A.-G., et al. (2026) · Brain Pathology · doi:10.1111/bpa.70143

Characterisation of pathogenic PTEN variants that retain AKT suppressive activity

Spinelli, L., Tibarewal, P., Maccario, H., Marzano, G., Berglund, F., Varyova, Z., Adil, M., Vanhaesebroeck, B., & Leslie, N. R. (2026) · Advances in Biological Regulation · doi:10.1016/j.jbior.2026.101185

Phosphatase-dependent function of PTEN in maintaining mitotic chromatin condensation

Li, K., Hou, S., Fan, X., & Shen, W. H. (2023) · BIOS · doi:10.1893/bios-d-21-00013

Overexpression of Eg5 Causes Genomic Instability and Tumor Formation in Mice

Castillo, A., Morse, H. C., Godfrey, V., Naeem, R., & Justice, M. J. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0326 · Cited by 150 · see citing works

Perturbation of Eg5 reveals insights into mitotic spindle structure and mechanics.

Kollu, S. (2010) · doi:10.1349/ddlp.396

Dynamic reorganization of Eg5 in the mammalian spindle throughout mitosis requires dynein and TPX2

Gable, A., Qiu, M., Titus, J., Balchand, S. K., Ferenz, N. P., Ma, N., Collins, E., Fagerstrom, C. J., Ross, J. L., Yang, G., et al. (2012) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-09-0820 · Cited by 55 · see citing works

TPX2 regulates the localization and activity of Eg5 in the mammalian mitotic spindle

Ma, N., Titus, J., Gable, A., Ross, J. L., & Wadsworth, P. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201106149 · Cited by 107 · see citing works