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Notch signaling: switching an oncogene to a tumor suppressor

Lobry, C., Oh, P., Mansour, M. R., Look, A. T., & Aifantis, I. (2014) · Blood · doi:10.1182/blood-2013-08-355818 · Cited by 249 · see citing works

Throwing the cancer switch: reciprocal roles of polycomb and trithorax proteins

Mills, A. A. (2010) · Nature reviews. Cancer · doi:10.1038/nrc2931 · Cited by 249 · see citing works

NOTCH1/FBXW7 mutation identifies a large subgroup with favorable outcome in adult T-cell acute lymphoblastic leukemia (T-ALL): a Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL) study

Asnafi, V., Buzyn, A., Noir, S. L., Baleydier, F., Simon, A., Beldjord, K., Reman, O., Witz, F., Fagot, T., Tavernier, E., et al. (2008) · Blood · doi:10.1182/blood-2008-10-184069 · Cited by 245 · see citing works

Targeted Nanoparticles for Imaging Incipient Pancreatic Ductal Adenocarcinoma

Kelly, K. A., Bardeesy, N. M., Anbazhagan, R., Gurumurthy, S., Berger, J. H., Alencar, H., DePinho, R. A., Mahmood, U., & Weissleder, R. (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050085 · Cited by 242 · see citing works

Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formation

Guo, W., Lasky, J. L., Chang, C.-J., Mosessian, S., Lewis, X., Xiao, Y., Yeh, J., Chen, J. Y., Iruela‐Arispe, M. L., Varella‐Garcia, M., et al. (2008) · Nature · doi:10.1038/nature06933 · Cited by 241 · see citing works

Cell competition is a tumour suppressor mechanism in the thymus

Martins, V. C., Busch, K., Juraeva, D., Blum, C., Ludwig, C., Rasche, V., Lasitschka, F., Mastitsky, S. E., Brors, B., Hielscher, T., et al. (2014) · Nature · doi:10.1038/nature13317 · Cited by 231 · see citing works

The role of the PTEN/AKT Pathway in NOTCH1-induced leukemia

Palomero, T., Domínguez, M., & Ferrando, A. A. (2008) · Cell Cycle · doi:10.4161/cc.7.8.5753 · Cited by 224 · see citing works

Human cancer cell lines: Experimental models for cancer cells in situ? For cancer stem cells?

van Staveren, W. C. G., Solís, D. Y. W., Hébrant, A., Detours, V., Dumont, J. E., & Maenhaut, C. (2009) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2008.12.004 · Cited by 222 · see citing works

Telomerase Reactivation following Telomere Dysfunction Yields Murine Prostate Tumors with Bone Metastases

Ding, Z., Wu, C.-J., Jaskelioff, M., Ivanova, E., Kost-Alimova, M., Protopopov, A., Chu, G. C., Wang, G., Lu, X., Labrot, E. S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.01.039 · Cited by 220 · see citing works

Telomere Dynamics in Mice and Humans

Calado, R. T., & Dumitriu, B. (2013) · Seminars in Hematology · doi:10.1053/j.seminhematol.2013.03.030 · Cited by 214 · see citing works

Genetically Engineered Mouse Models in Cancer Research

Walrath, J. C., Hawes, J. J., Dyke, T. V., & Reilly, K. M. (2010) · Advances in cancer research · doi:10.1016/s0065-230x(10)06004-5 · Cited by 210 · see citing works

mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization

Gan, B., Sahin, E., Jiang, S., Sánchez‐Aguilera, A., Scott, K. L., Chin, L., Williams, D. A., Kwiatkowski, D. J., & DePinho, R. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810584105 · Cited by 200 · see citing works

The Quest for the 1p36 Tumor Suppressor

Bagchi, A., & Mills, A. A. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-2095 · Cited by 196 · see citing works

Mutational landscape of <i>EGFR-</i> , <i>MYC-</i> , and <i>Kras-</i> driven genetically engineered mouse models of lung adenocarcinoma

McFadden, D. G., Politi, K., Bhutkar, A., Chen, F. K., Song, X., Pirun, M., Santiago, P. M., Kim-Kiselak, C., Platt, J. T., Lee, E., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1613601113 · Cited by 194 · see citing works

An iPSC Line from Human Pancreatic Ductal Adenocarcinoma Undergoes Early to Invasive Stages of Pancreatic Cancer Progression

Kim, J., Hoffman, J. P., Alpaugh, R. K., Rhim, A. D., Reichert, M., Stanger, B. Z., Furth, E. E., Sepulveda, A. R., Yuan, C., Won, K., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.05.036 · Cited by 188 · see citing works

DLC1 is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinomaPreprint

Xue, W., Krasnitz, A., Lucito, R., Sordella, R., Aelst, L. V., Cordon‐Cardo, C., Singer, S., Kuehnel, F., Wigler, M. H., Powers, S., et al. (2008) · Genes & Development · doi:10.1101/gad.1672608 · Cited by 188 · see citing works

KPT ‐330 inhibitor of CRM 1 ( XPO 1)‐mediated nuclear export has selective anti‐leukaemic activity in preclinical models of T ‐cell acute lymphoblastic leukaemia and acute myeloid leukaemia

Etchin, J., Sanda, T., Mansour, M. R., Kentsis, A., Montero, J., Le, B. T., Christie, A. L., McCauley, D., Rodig, S. J., Kauffman, M. G., et al. (2013) · British Journal of Haematology · doi:10.1111/bjh.12231 · Cited by 182 · see citing works

Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALLPreprint

Matsuoka, S., Oike, Y., Onoyama, I., Iwama, A., Arai, F., Takubo, K., Mashimo, Y., Oguro, H., Nitta, E., Ito, K., et al. (2008) · Genes & Development · doi:10.1101/gad.1621808 · Cited by 183 · see citing works

Non-germline genetically engineered mouse models for translational cancer research

Heyer, J., Kwong, L. N., Lowe, S. W., & Chin, L. (2010) · Nature reviews. Cancer · doi:10.1038/nrc2877 · Cited by 179 · see citing works

Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7

Thompson, B. J., Janković, V., Gao, J., Buonamici, S., Vest, A., Lee, J. M., Zavadil, J., Nimer, S. D., & Aifantis, I. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080277 · Cited by 171 · see citing works

Merkel Cell Polyomavirus Small T Antigen Controls Viral Replication and Oncoprotein Expression by Targeting the Cellular Ubiquitin Ligase SCFFbw7

Kwun, H. J., Shuda, M., Feng, H., Camacho, C. J., Moore, P. S., & Chang, Y. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.06.008 · Cited by 170 · see citing works

High-level IGF1R expression is required for leukemia-initiating cell activity in T-ALL and is supported by Notch signaling

Medyouf, H., Gusscott, S., Wang, H., Tseng, J., Wai, C., Nemirovsky, O., Trumpp, A., Pflumio, F., Carboni, J. M., Gottardis, M. M., et al. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20110121 · Cited by 167 · see citing works

Notch signalling in T‐cell lymphoblastic leukaemia/lymphoma and other haematological malignancies

Aster, J. C., Blacklow, S. C., & Pear, W. S. (2010) · The Journal of Pathology · doi:10.1002/path.2789 · Cited by 163 · see citing works

Notch pathway activation targets AML-initiating cell homeostasis and differentiation

Lobry, C., Ntziachristos, P., Ndiaye‐Lobry, D., Oh, P., Cimmino, L., Zhu, N., Araldi, E., Hu, W., Freund, J. E., Abdel-Wahab, O. I., et al. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20121484 · Cited by 159 · see citing works

The TLX1 oncogene drives aneuploidy in T cell transformation

Keersmaecker, K. D., Real, P. J., Gatta, G. D., Palomero, T., Sulis, M. L., Tosello, V., Vlierberghe, P. V., Barnes, K., Castillo-Martín, M., Solé, X., et al. (2010) · Nature Medicine · doi:10.1038/nm.2246 · Cited by 158 · see citing works

c-Myc inhibition prevents leukemia initiation in mice and impairs the growth of relapsed and induction failure pediatric T-ALL cells

Roderick, J. E., Tesell, J., Shultz, L. D., Brehm, M. A., Greiner, D. L., Harris, M. H., Silverman, L. B., Sallan, S. E., Gutiérrez, A., Look, A. T., et al. (2014) · Blood · doi:10.1182/blood-2013-08-522698 · Cited by 157 · see citing works

IFN-γ is required for cytotoxic T cell-dependent cancer genome immunoediting

Takeda, K., NAKAYAMA, M., Hayakawa, Y., Kojima, Y., Ikeda, H., Imai, N., Ogasawara, K., Okumura, K., Thomas, D. M., & Smyth, M. J. (2017) · Nature Communications · doi:10.1038/ncomms14607 · Cited by 156 · see citing works

Molecular‐genetic insights in paediatric T‐cell acute lymphoblastic leukaemia

Vlierberghe, P. V., Pieters, R., Beverloo, H. B., & Meijerink, J. P. P. (2008) · British Journal of Haematology · doi:10.1111/j.1365-2141.2008.07314.x · Cited by 155 · see citing works

Integrating high-throughput technologies in the quest for effective biomarkers for ovarian cancer

Kulasingam, V., Pavlou, M. P., & Diamandis, E. P. (2010) · Nature reviews. Cancer · doi:10.1038/nrc2831 · Cited by 150 · see citing works

Chromosomes and cancer cells

Thompson, S. L., & Compton, D. A. (2010) · Chromosome Research · doi:10.1007/s10577-010-9179-y · Cited by 153 · see citing works

‘One medicine—one pathology': are veterinary and human pathology prepared?

Cardiff, R. D., Ward, J. M., & Barthold, S. W. (2007) · Laboratory Investigation · doi:10.1038/labinvest.3700695 · Cited by 150 · see citing works

Genome-wide profiling of genetic alterations in acute lymphoblastic leukemia: recent insights and future directions

Mullighan, C. G., & Downing, J. R. (2009) · Leukemia · doi:10.1038/leu.2009.18 · Cited by 147 · see citing works

Negative Regulation of the Stability and Tumor Suppressor Function of Fbw7 by the Pin1 Prolyl Isomerase

Min, S. H., Lau, A. W., Lee, T. H., Inuzuka, H., Wei, S., Huang, P., Shaik, S., Lee, D. Y., Finn, G., Balaštík, M., et al. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.04.012 · Cited by 146 · see citing works

Exonuclease-1 Deletion Impairs DNA Damage Signaling and Prolongs Lifespan of Telomere-Dysfunctional Mice

Schaetzlein, S., Nalapareddy, K., Ju, Z., Lechel, A., Stępczyńska, A., Lilli, D. R., Clark, A. B., Rudolph, C., Kühnel, F., Wei, K., et al. (2007) · Cell · doi:10.1016/j.cell.2007.08.029 · Cited by 144 · see citing works

Histone deacetylase 1 and 2 are essential for normal T-cell development and genomic stability in mice

Dovey, O. M., Foster, C. T., Conte, N., Edwards, S. A., Edwards, J. M., Singh, R., Vassiliou, G. S., Bradley, A., & Cowley, S. M. (2013) · Blood · doi:10.1182/blood-2012-07-441949 · Cited by 143 · see citing works

A new domestic cat genome assembly based on long sequence reads empowers feline genomic medicine and identifies a novel gene for dwarfism

Buckley, R. M., Davis, B. W., Brashear, W. A., Farias, F. G., Kuroki, K., Graves, T., Hillier, L., Kremitzki, M., Li, G., Middleton, R. P., et al. (2020) · PLoS Genetics · doi:10.1371/journal.pgen.1008926 · Cited by 140 · see citing works

Targeting the Notch1 and mTOR pathways in a mouse T-ALL model

Cullion, K., Draheim, K., Hermance, N. M., Tammam, J. G., Sharma, V. M., Ware, C. M., Nikov, G. N., Krishnamoorthy, V., Majumder, P. K., & Kelliher, M. A. (2009) · Blood · doi:10.1182/blood-2008-02-136762 · Cited by 139 · see citing works

The TAL1 complex targets the FBXW7 tumor suppressor by activating miR-223 in human T cell acute lymphoblastic leukemia

Mansour, M. R., Sanda, T., Lawton, L. N., Li, X., Kreslavsky, T., Novina, C. D., Brand, M., Gutiérrez, A., Kelliher, M. A., Jamieson, C. H. M., et al. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20122516 · Cited by 135 · see citing works

HtrA Serine Proteases as Potential Therapeutic Targets in Cancer

CHIEN, J. R., Campioni, M., Shridhar, V., & Baldi, A. (2009) · Current Cancer Drug Targets · doi:10.2174/156800909788486704 · Cited by 134 · see citing works

NOTCH1 and FBXW7 mutations have a favorable impact on early response to treatment, but not on outcome, in children with T-cell acute lymphoblastic leukemia (T-ALL) treated on EORTC trials 58881 and 58951

Clappier, E., Collette, S., Grardel, N., Girard, S., Suarez, L., Brunie, G., Kaltenbach, S., Yakouben, K., Mazingue, F., Robert, A., et al. (2010) · Leukemia · doi:10.1038/leu.2010.205 · Cited by 128 · see citing works

Role of telomeres and telomerase in genomic instability, senescence and cancer

Deng, Y., & Chang, S. S. (2007) · Laboratory Investigation · doi:10.1038/labinvest.3700673 · Cited by 125 · see citing works

The favorable effect of activating NOTCH1 receptor mutations on long-term outcome in T-ALL patients treated on the ALL–BFM 2000 protocol can be separated from FBXW7 loss of function

Kox, C., Zimmermann, M., Stanulla, M., Leible, S., Schrappe, M., Ludwig, W.-D., Koehler, R., Tolle, G., Bandapalli, O. R., Breit, S., et al. (2010) · Leukemia · doi:10.1038/leu.2010.203 · Cited by 127 · see citing works

Mechanisms of transcription factor deregulation in lymphoid cell transformation

O’Neil, J., & Look, A. T. (2007) · Oncogene · doi:10.1038/sj.onc.1210766 · Cited by 122 · see citing works

The significance of PTEN and AKT aberrations in pediatric T-cell acute lymphoblastic leukemia

Zuurbier, L. C., Petricoin, E. F., Vuerhard, M., Calvert, V. S., Kooi, C., Buijs-Gladdines, J. G. C. A. M., Smits, W. K., Sonneveld, E., Veerman, A. J. P., Kamps, W. A., et al. (2012) · Haematologica · doi:10.3324/haematol.2011.059030 · Cited by 122 · see citing works

Inactivation of LEF1 in T-cell acute lymphoblastic leukemia

Gutiérrez, A., Sanda, T., Ma, W., Zhang, J., Grebliunaite, R., Dahlberg, S. E., Neuberg, D. S., Protopopov, A. I., Winter, S. S., Larson, R. A., et al. (2010) · Blood · doi:10.1182/blood-2009-07-234377 · Cited by 120 · see citing works

Vital roles of mTOR complex 2 in Notch-driven thymocyte differentiation and leukemia

Lee, K., Nam, K. T., Cho, S. H., Gudapati, P., Hwang, Y., Park, D., Potter, R. M., Chen, J., Volanakis, E. J., & Boothby, M. R. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20111470 · Cited by 120 · see citing works

Feedback Circuit among INK4 Tumor Suppressors Constrains Human Glioblastoma Development

Wiedemeyer, R., Brennan, C. W., Heffernan, T. P., Xiao, Y., Mahoney, J. E., Protopopov, A. I., Zheng, H., Bignell, G. R., Furnari, F. B., Cavenee, W. K., et al. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.02.010 · Cited by 119 · see citing works

Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver

Onoyama, I., Suzuki, A., Matsumoto, A., Tomita, K., Katagiri, H., Oike, Y., Nakayama, K., & Nakayama, K. (2010) · Journal of Clinical Investigation · doi:10.1172/jci40725 · Cited by 118 · see citing works

Prognostic Implications of NOTCH1 and FBXW7 Mutations in Adults With T-Cell Acute Lymphoblastic Leukemia Treated on the MRC UKALLXII/ECOG E2993 Protocol

Mansour, M. R., Sulis, M. L., Duke, V. M., Foroni, L., Jenkinson, S., Koo, K., Allen, C. G., Gale, R. E., Buck, G. A. N., Richards, S. M., et al. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2009.22.0996 · Cited by 115 · see citing works

Regulation of cell differentiation by the DNA damage response

Sherman, M. H., Bassing, C. H., & Teitell, M. A. (2011) · Trends in Cell Biology · doi:10.1016/j.tcb.2011.01.004 · Cited by 112 · see citing works

The ubiquitous nature of cancer: the role of the SCFFbw7 complex in development and transformation

Moran-Crusio, K., King, B., Reavie, L. B., & Aifantis, I. (2010) · Oncogene · doi:10.1038/onc.2010.222 · Cited by 111 · see citing works

The Fbw7 and BetaTRCP E3 ubiquitin ligases and their roles in tumorigenesis

Alan, W. L. (2012) · Frontiers in bioscience · doi:10.2741/4045 · Cited by 112 · see citing works

STAR RNA-binding protein Quaking suppresses cancer via stabilization of specific miRNAPreprint

Chen, A.-J., Paik, J.-H., Zhang, H., Shukla, S. A., Mortensen, R., HU, J. L., Ying, H., Hu, B., Hurt, J. A., Farny, N. G., et al. (2012) · Genes & Development · doi:10.1101/gad.189001.112 · Cited by 111 · see citing works

The Biology of F-box Proteins: The SCF Family of E3 Ubiquitin Ligases

Nguyen, K. M., & Busino, L. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-981-15-1025-0_8 · Cited by 106 · see citing works

Activation of β‐Catenin in mouse prostate causes HGPIN and continuous prostate growth after castration

Yu, X., Wang, Y., Jiang, M., Bierie, B., Roy‐Burman, P., Shen, M. M., Taketo, M. M., Wills, M. L., & Matusik, R. J. (2008) · The Prostate · doi:10.1002/pros.20877 · Cited by 107 · see citing works

Role of the ubiquitin ligase Fbw7 in cancer progression

Cheng, Y., & Li, G. (2011) · Cancer and Metastasis Reviews · doi:10.1007/s10555-011-9330-z · Cited by 105 · see citing works

Mouse Models of Prostate Cancer

Valkenburg, K. C., & Williams, B. O. (2011) · Prostate Cancer · doi:10.1155/2011/895238 · Cited by 107 · see citing works

Notch1 inhibition targets the leukemia-initiating cells in a Tal1/Lmo2 mouse model of T-ALL

Tatarek, J., Cullion, K., Ashworth, T. D., Gerstein, R. M., Aster, J. C., & Kelliher, M. A. (2011) · Blood · doi:10.1182/blood-2010-08-300343 · Cited by 104 · see citing works

Fenton reaction induced cancer in wild type rats recapitulates genomic alterations observed in human cancer

Akatsuka, S., Yamashita, Y., Ohara, H., Liu, Y.-T., Izumiya, M., Abe, K., Ochiai, M., Jiang, L., Nagai, H., Okazaki, Y., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043403 · Cited by 102 · see citing works

1p36 Tumor Suppression—A Matter of Dosage?

Henrich, K., Schwab, M., & Westermann, F. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-2230 · Cited by 101 · see citing works

Negative prognostic impact of PTEN mutation in pediatric T-cell acute lymphoblastic leukemia

Jotta, P. Y., Ganazza, M., SILVA, A. A. A. D., Viana, M. B., da Silva, M. J., Zambaldi, L. D. J. G., Barata, J. T., Brandalise, S. R., & Yunes, J. A. (2009) · Leukemia · doi:10.1038/leu.2009.209 · Cited by 99 · see citing works

Oncogenesis of T-ALL and nonmalignant consequences of overexpressing intracellular NOTCH1

Li, X., Gounari, F., Protopopov, A. I., Khazaie, K., & von Boehmer, H. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20081561 · Cited by 97 · see citing works

Prkar1a is an osteosarcoma tumor suppressor that defines a molecular subclass in mice

Molyneux, S. D., Grappa, M. A. D., Beristain, A. G., McKee, T. D., Wai, D., Paderova, J., Kashyap, M., Hu, P., Maiuri, T., Narala, S., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci42391 · Cited by 98 · see citing works

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Somatic mutations in murine models of leukemia and lymphoma: Disease specificity and clinical relevance

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Unraveling human cancer in the mouse: recent refinements to modeling and analysis

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Development and Application of MiMouse, a Comprehensive Genomic Profiling Panel for Credentialing Mouse Tumor Models

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