The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
CO2 fixation by anaerobic non-photosynthetic mixotrophy for improved carbon conversion
Open accessAbstract
Maximizing the conversion of biogenic carbon feedstocks into chemicals and fuels is essential for fermentation processes as feedstock costs and processing is commonly the greatest operating expense. Unfortunately, for most fermentations, over one-third of sugar carbon is lost to CO 2 due to the decarboxylation of pyruvate to acetyl-CoA and limitations in the reducing power of the bio-feedstock. Here we show that anaerobic, non-photosynthetic mixotrophy, defined as the concurrent utilization of organic (for example, sugars) and inorganic (for example, CO 2) substrates in a single organism, can overcome these constraints to increase product yields and reduce overall CO 2 emissions. As a proof-of-concept, Clostridium ljungdahlii was engineered to produce acetone and achieved a mass yield 138% of the previous theoretical maximum using a high cell density continuous fermentation process. In addition, when enough reductant (that is, H 2) is provided, the fermentation emits no CO 2. Finally, we show that mixotrophy is a general trait among acetogens.
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Cites
Non-fermentative pathways for synthesis of branched-chain higher alcohols as biofuels
Atsumi, S., Hanai, T., & Liao, J. C. (2008) · Nature · doi:10.1038/nature06450 · Cited by 1,945
Leang, C., Ueki, T., Nevin, K. P., & Lovley, D. R. (2013) · Applied and Environmental Microbiology · doi:10.1128/aem.02891-12 · Cited by 202
Converting carbon dioxide to butyrate with an engineered strain of Clostridium ljungdahlii
Ueki, T., Nevin, K. P., Woodard, T. L., & Lovley, D. R. (2014) · mBio · doi:10.1128/mbio.01636-14 · Cited by 175
Nagarajan, H., Sahin, M., Nogales, J., Latif, H., Lovley, D. R., Ebrahim, A., & Zengler, K. (2013) · Microbial Cell Factories · doi:10.1186/1475-2859-12-118 · Cited by 170
Acetone production with metabolically engineered strains of Acetobacterium woodii
Hoffmeister, S., Gerdom, M., Bengelsdorf, F. R., Linder, S., Flüchter, S., Öztürk, H., Blümke, W., May, A., Fischer, R.-J., Bahl, H., et al. (2016) · Metabolic Engineering · doi:10.1016/j.ymben.2016.03.001 · Cited by 139
Lactose-inducible system for metabolic engineering of Clostridium ljungdahlii
Banerjee, A., Leang, C., Ueki, T., Nevin, K. P., & Lovley, D. R. (2014) · Applied and Environmental Microbiology · doi:10.1128/aem.03666-13 · Cited by 126
Cited by
Technical photosynthesis involving CO2 electrolysis and fermentation
Haas, T., Krause, R., Weber, R., Demler, M., & Schmid, G. (2018) · Nature Catalysis · doi:10.1038/s41929-017-0005-1 · Cited by 649
Carbon-negative production of acetone and isopropanol by gas fermentation at industrial pilot scale
Liew, F. E., Nogle, R., Abdalla, T., Rasor, B. J., Canter, C., Jensen, R. O., Wang, L., Strutz, J., Chirania, P., De Tissera, S., et al. (2022) · Nature Biotechnology · doi:10.1038/s41587-021-01195-w · Cited by 481
Transformation technologies for CO2 utilisation: Current status, challenges and future prospects
Kamkeng, A. D. N., Wang, M., Hu, J., Du, W., & Qian, F. (2021) · Chemical Engineering Journal · doi:10.1016/j.cej.2020.128138 · Cited by 475
Third-generation biorefineries as the means to produce fuels and chemicals from CO2
Liu, Z., Wang, K., Chen, Y., Tan, T., & Nielsen, J. (2020) · Nature Catalysis · doi:10.1038/s41929-019-0421-5 · Cited by 469
Recent advances in single cell protein use as a feed ingredient in aquaculture
Jones, S. W., Karpol, A., Friedman, S., Maru, B. T., & Tracy, B. P. (2020) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2019.12.026 · Cited by 353
Self-citation
Metadata
- Authors
- Jones, S. W., Fast, A. G., Carlson, E. D., Wiedel, C. A., Au, J., Antoniewicz, M. R., Papoutsakis, E. T., & Tracy, B. P.
- Venue
- Nature Communications
- Published
- 2016-09-30
- Volume
- 7
- Issue
- 1
- Pages
- 12800-12800
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2526367077
- Cited by
- 197
- References
- 6
- FWCI
- 6.17
- Type
- journal article
- Language
- en
- Open access
- gold
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- Jones, S. W., Fast, A. G., Carlson, E. D., Wiedel, C. A., Au, J., Antoniewicz, M. R., Papoutsakis, E. T., & Tracy, B. P. (2016). CO2 fixation by anaerobic non-photosynthetic mixotrophy for improved carbon conversion. Nature Communications. https://doi.org/10.1038/ncomms12800
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
