The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
The lipid sensor GPR120 promotes brown fat activation and FGF21 release from adipocytes
Open accessAbstract
The thermogenic activity of brown adipose tissue (BAT) and browning of white adipose tissue are important components of energy expenditure. Here we show that GPR120, a receptor for polyunsaturated fatty acids, promotes brown fat activation. Using RNA-seq to analyse mouse BAT transcriptome, we find that the gene encoding GPR120 is induced by thermogenic activation. We further show that GPR120 activation induces BAT activity and promotes the browning of white fat in mice, whereas GRP120-null mice show impaired cold-induced browning. Omega-3 polyunsaturated fatty acids induce brown and beige adipocyte differentiation and thermogenic activation, and these effects require GPR120. GPR120 activation induces the release of fibroblast growth factor-21 (FGF21) by brown and beige adipocytes, and increases blood FGF21 levels. The effects of GPR120 activation on BAT activation and browning are impaired in FGF21-null mice and cells. Thus, the lipid sensor GPR120 activates brown fat via a mechanism that involves induction of FGF21.
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RNA-Seq: a revolutionary tool for transcriptomics
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FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis
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Development of obesity in transgenic mice after genetic ablation of brown adipose tissue
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“Our data indicate that GPR120 activation plays a dual role, namely: (1) it promotes the differentiation of pre-adipocytes into the brown and beige lineages; and (2) it promotes thermogenic activation in differentiated brown and beige adipocytes.”
BackgroundTranscriptome genetics using second generation sequencing in a Caucasian population
Montgomery, S. B., Sammeth, M., Gutierrez-Arcelus, M., Lach, R. P., Ingle, C., Nisbett, J., Guigo, R., & Dermitzakis, E. T. (2010) · Nature · doi:10.1038/nature08903 · Cited by 797
Thermogenic Activation Induces FGF21 Expression and Release in Brown Adipose Tissue
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Self-citationHondares, E., Rosell, M., Gonzalez, F. J., Giralt, M., Iglesias, R., & Villarroya, F. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.02.001 · Cited by 377
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Kimura, I., Ichimura, A., Ohue-Kitano, R., & Igarashi, M. (2020) · Physiological Reviews · doi:10.1152/physrev.00041.2018 · Cited by 1,018
Diversity and versatility of p38 kinase signalling in health and disease
Canovas, B., & Nebreda, A. R. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00322-w · Cited by 657
PPAR Agonists and Metabolic Syndrome: An Established Role?
Botta, M., Audano, M., Sahebkar, A., Sirtori, C., Mitro, N., & Ruscica, M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19041197 · Cited by 253
Cereijo, R., Gavaldà-Navarro, A., Cairó, M., Quesada-López, T., Villarroya, J., Morón-Ros, S., Sánchez-Infantes, D., Peyrou, M., Iglesias, R., Mampel, T., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.07.015 · Cited by 236
Self-citationHan, Y.-H., Shin, K.-O., Kim, J.-Y., Khadka, D. B., Kim, H.-J., Lee, Y.-M., Cho, W.-J., Cha, J.-Y., Lee, B.-J., & Lee, M.-O. (2019) · Journal of Clinical Investigation · doi:10.1172/jci124219 · Cited by 154
Metadata
- Authors
- Quesada-López, T., Cereijo, R., Turatsinze, J.-V., Planavila, A., Cairó, M., Gavaldà-Navarro, A., Peyrou, M., Moure, R., Iglesias, R., Giralt, M., Eizirik, D. L., & Villarroya, F.
- Venue
- Nature Communications
- Published
- 2016-11-17
- Volume
- 7
- Issue
- 1
- Pages
- 13479-13479
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2554388788
- Cited by
- 231
- References
- 13
- FWCI
- 15.29
- Type
- journal article
- Language
- en
- Open access
- gold
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