Accelerating the search for the missing proteins in the human proteome
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The Human Proteome Project (HPP) aims to discover high-stringency data for all proteins encoded by the human genome. Currently, ∼18% of the proteins in the human proteome (the missing proteins) do not have high-stringency evidence (for example, mass spectrometry) confirming their existence, while much additional information is available about many of these missing proteins. Here, we present MissingProteinPedia as a community resource to accelerate the discovery and understanding of these missing proteins. The Human Proteome Project aims to catalogue the ∼20,000 proteins encoded by the human genome. In this review, Bakeret al. focus on the missing proteins, proteins that lack high stringency proteomic evidence, and launch MissingProteinPedia, a database aimed at accelerating the search for missing proteins.
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The human proteome project reports that an estimated ~20% of genes yield protein products that are not detected by mass spectrometry.
“For example, the human proteome project reports that an estimated ~20% of genes yield protein products that are not detected by mass spectrometry, an analytic platform for protein quantification (Paik et al., 2012; Baker et al., 2017).”
From Missing data in multi-omics integration: Recent advances through artificial intelligence (2023) · cites this paper as Baker et al., 2017
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“For example, the human proteome project reports that an estimated ∼ 20% of genes yield protein products that are not detected by mass spectrometry, an analytic platform for protein quantification (Paik et al., 2012; Baker et al., 2017).”
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- Authors
- Baker, M. S., Ahn, S. B., Mohamedali, A., Islam, M. T., Cantor, D., Verhaert, P. D., Fanayan, S., Sharma, S., Nice, E. C., Connor, M., & Ranganathan, S.
- Affiliations
- Macquarie University (AU)
- University of Antwerp (BE)
- Monash University (AU)
- Corresponding author
- Baker, Mark S.
- ORCID
- Venue
- Nature Communications
- Published
- 2017-01-24
- Volume
- 8
- Issue
- 1
- Pages
- 14271-14271
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC5286205
- OpenAlex
- W2580329791
- Cited by
- 100
- References
- 59
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 5 · 2023: 4 · 2022: 3 · 2021: 9 · 2020: 16 · 2019: 27 · 2018: 17 · 2017: 14
- FWCI
- 2.32
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- Monash University Research Portal (Monash University) (publishedVersion, other-oa)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Australian Government
- Macquarie University
- Topics
- Physical Sciences › Chemistry › Spectroscopy › Advanced Proteomics Techniques and Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Keywords
- missing proteins, human proteome, Human Proteome Project, proteomics database, protein discovery, human genome
- MeSH terms
- Proteogenomics, Chromosome Mapping, Chromosomes, Human, Humans, Genome, Human, Proteome, Databases, Protein, Receptors, G-Protein-Coupled
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