The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Rational Engineering of a Dynamic, Entropy‐Driven DNA Nanomachine for Intracellular MicroRNA Imaging
Abstract
We rationally engineered an elegant entropy‐driven DNA nanomachine with three‐dimensional track and applied it for intracellular miRNAs imaging. The proposed nanomachine is activated by target miRNA binding to drive a walking leg tethered to gold nanoparticle with a high density of DNA substrates. The autonomous and progressive walk on the DNA track via the entropy‐driven catalytic reaction of intramolecular toehold‐mediated strand migration leads to continuous disassembly of DNA substrates, accompanied by the recovery of fluorescence signal due to the specific release of a dye‐labeled substrate from DNA track. Our nanomachine outperforms the conventional intermolecular reaction‐based gold nanoparticle design in the context of an improved sensitivity and kinetics, attributed to the enhanced local effective concentrations of working DNA components from the proximity‐induced intramolecular reaction. Moreover, the nanomachine was applied for miRNA imaging inside living cells.
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Cites
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Engineering Entropy-Driven Reactions and Networks Catalyzed by DNA
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MicroRNA-34a regulates cardiac ageing and function.
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Nano-Flares: Probes for Transfection and mRNA Detection in Living Cells
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A microRNA-initiated DNAzyme motor operating in living cells
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A Multicolor Nanoprobe for Detection and Imaging of Tumor‐Related mRNAs in Living Cells
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Metadata
- Authors
- Liang, C., Ma, P., Liu, H., Guo, X., Yin, B., & Ye, B.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2017-06-28
- Volume
- 56
- Issue
- 31
- Pages
- 9077-9081
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2625437134
- Cited by
- 389
- References
- 18
- FWCI
- 15.04
- Type
- journal article
- Language
- en
- Open access
- closed
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