The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.
A Pseudomonas T6SS effector recruits PQS-containing outer membrane vesicles for iron acquisition
Open accessAbstract
Iron sequestration by host proteins contributes to the defence against bacterial pathogens, which need iron for their metabolism and virulence. A Pseudomonas aeruginosa mutant lacking all three known iron acquisition systems retains the ability to grow in media containing iron chelators, suggesting the presence of additional pathways involved in iron uptake. Here we screen P. aeruginosa mutants defective in growth in iron-depleted media and find that gene PA2374, proximal to the type VI secretion system H3 (H3-T6SS), functions synergistically with known iron acquisition systems. PA2374 (which we have renamed TseF) appears to be secreted by H3-T6SS and is incorporated into outer membrane vesicles (OMVs) by directly interacting with the iron-binding Pseudomonas quinolone signal (PQS), a cell–cell signalling compound. TseF facilitates the delivery of OMV-associated iron to bacterial cells by engaging the Fe(III)-pyochelin receptor FptA and the porin OprF. Our results reveal links between type VI secretion, cell–cell signalling and classic siderophore receptors for iron acquisition in P. aeruginosa.
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Pena, R. T., Blasco, L., Ambroa, A., González-Pedrajo, B., Fernández-García, L., López, M., Bleriot, I., Bou, G., García-Contreras, R., Wood, T. K., et al. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.01100 · Cited by 299
Bahr, G., González, L. J., & Vila, A. J. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00138 · Cited by 266
Coordination of fungal biofilm development by extracellular vesicle cargo
Zarnowski, R., Noll, A., Chevrette, M. G., Sanchez, H., Jones, R., Anhalt, H., Fossen, J., Jaromin, A., Currie, C., Nett, J. E., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26525-z · Cited by 123
A common vesicle proteome drives fungal biofilm development
Zarnowski, R., Sanchez, H., Jaromin, A., Zarnowska, U. J., Nett, J. E., Mitchell, A. P., & Andes, D. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2211424119 · Cited by 63
Metadata
- Authors
- Lin, J., Zhang, W., Cheng, J., Yang, X., Zhu, K., Wang, Y., Wei, G., Qian, P.-Y., Luo, Z.-Q., & Shen, X.
- Venue
- Nature Communications
- Published
- 2017-03-28
- Volume
- 8
- Issue
- 1
- Pages
- 14888-14888
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2597760097
- Cited by
- 316
- References
- 66
- FWCI
- 9.80
- Type
- journal article
- Language
- en
- Open access
- gold
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- Lin, J., Zhang, W., Cheng, J., Yang, X., Zhu, K., Wang, Y., Wei, G., Qian, P.-Y., Luo, Z.-Q., & Shen, X. (2017). A Pseudomonas T6SS effector recruits PQS-containing outer membrane vesicles for iron acquisition. Nature Communications. https://doi.org/10.1038/ncomms14888
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