The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Real-time reliable determination of binding kinetics of DNA hybridization using a multi-channel graphene biosensor
Open accessAbstract
Reliable determination of binding kinetics and affinity of DNA hybridization and single-base mismatches plays an essential role in systems biology, personalized and precision medicine. The standard tools are optical-based sensors that are difficult to operate in low cost and to miniaturize for high-throughput measurement. Biosensors based on nanowire field-effect transistors have been developed, but reliable and cost-effective fabrication remains a challenge. Here, we demonstrate that a graphene single-crystal domain patterned into multiple channels can measure time- and concentration-dependent DNA hybridization kinetics and affinity reliably and sensitively, with a detection limit of 10 pM for DNA. It can distinguish single-base mutations quantitatively in real time. An analytical model is developed to estimate probe density, efficiency of hybridization and the maximum sensor response. The results suggest a promising future for cost-effective, high-throughput screening of drug candidates, genetic variations and disease biomarkers by using an integrated, miniaturized, all-electrical multiplexed, graphene-based DNA array.
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Cites
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Piezoelectric Biomaterials for Sensors and Actuators
Chorsi, M. T., Curry, E. J., Chorsi, H. T., Das, R., Baroody, J., Purohit, P. K., Ilies, H., & Nguyen, T. D. (2019) · Advanced Materials · doi:10.1002/adma.201802084 · Cited by 865
Electrically-Transduced Chemical Sensors Based on Two-Dimensional Nanomaterials
Meng, Z., Stolz, R. M., Mendecki, L., & Mirica, K. A. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00311 · Cited by 773
Graphene-Based Materials for Biosensors: A Review
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Metadata
- Authors
- Xu, S., Zhan, J., Man, B., Jiang, S., Yue, W., Gao, S., Guo, C., Liu, H., Li, Z., Wang, J., & Zhou, Y.
- Venue
- Nature Communications
- Published
- 2017-03-21
- Volume
- 8
- Issue
- 1
- Pages
- 14902-14902
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2603262868
- Cited by
- 437
- References
- 54
- FWCI
- 16.69
- Type
- journal article
- Language
- en
- Open access
- gold
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