Cited by 17Advanced biosensing and bioanalysis techniquesDNA and Nucleic Acid ChemistryDNA and Biological Computing

Enhanced SNP-sensing using DNA-templated reactions through confined hybridization of minimal substrates (CHOMS)

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Kim, Ki Tae, Winssinger, Nicolas·2020·Chemical Science

Abstract

Confined hybridization of a minimal substrate: striking the right balance between specificity and turnover

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Integrity signals

Registry

Crossref · 10.1039/d0sc00741b

Cites

66 of 66 references verified0 citation errors · 0 not checkable

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  • An additional 4-mer hybridizing adjacent to the 4-mer participating in primer extension improved the rate of reaction and fidelity of primer extension.

    “This further improved the rate of reaction and fidelity of primer extension (Figure 3D), consistent with prior work.9,40”

    From Sequencing of <scp>d</scp>/<scp>l</scp>-DNA and XNA by Templated-Synthesis (2025) · cites this paper as [40]

    The Results and discussion section reports that adjacent hybridization made a DNA-templated reaction with a short substrate faster than a reaction with a three-nucleotide gap. It does not test an additional 4-mer beside a primer-extension 4-mer or report improved primer-extension fidelity; its reaction is a ruthenium-photocatalyzed fluorescence assay. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

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Research works printed but not linked: 2

  1. Minamoto T. Mai M. Ronai Z. Cancer Detect. Prev. 2000 24 1 12 10757118
  2. McLornan D. Percy M. McMullin M. F. Ulster Med. J. 2006 75 112 119 16755940 PMC1891745

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Authors
Kim, K. T., & Winssinger, N.
Affiliations
University of Geneva (CH)
Corresponding author
Winssinger, Nicolas
Venue
Chemical Science
Published
2020
Volume
11
Issue
16
Pages
4150-4157
ISSN
  • 2041-6520 (ISSN-L)
  • 2041-6539
OpenAlex
W3013247789
Cited by
17
References
66
Citations by year
2026: 1 · 2025: 2 · 2024: 2 · 2023: 1 · 2022: 5 · 2021: 6
FWCI
0.97
Type
journal article
Language
en
Open access
Locations
  • Chemical Science (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Archive ouverte UNIGE (University of Geneva) (publishedVersion, other-oa)
  • Archive ouverte UNIGE (University of Geneva) (submittedVersion, other-oa)
Funders
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (200020_169141, 200020_188406)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Biological Computing
Keywords
single nucleotide polymorphism detection, signal amplification, single-nucleotide discrimination, π-π stacking, oncogenic mutations, nucleic acid sensing

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