The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Dual-stimuli responsive and reversibly activatable theranostic nanoprobe for precision tumor-targeting and fluorescence-guided photothermal therapy
Open accessAbstract
The integrated functions of diagnostics and therapeutics make theranostics great potential for personalized medicine. Stimulus-responsive therapy allows spatial control of therapeutic effect only in the site of interest, and offers promising opportunities for imaging-guided precision therapy. However, the imaging strategies in previous stimulus-responsive therapies are ‘always on’ or irreversible ‘turn on’ modality, resulting in poor signal-to-noise ratios or even ‘false positive’ results. Here we show the design of dual-stimuli-responsive and reversibly activatable nanoprobe for precision tumour-targeting and fluorescence-guided photothermal therapy. We fabricate the nanoprobe from asymmetric cyanine and glycosyl-functionalized gold nanorods (AuNRs) with matrix metalloproteinases (MMPs)-specific peptide as a linker to achieve MMPs/pH synergistic and pH reversible activation. The unique activation and glycosyl targetibility makes the nanoprobe bright only in tumour sites with negligible background, while AuNRs and asymmetric cyanine give synergistic photothermal effect. This work paves the way to designing efficient nanoprobes for precision theranostics.
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Cites
New functions for the matrix metalloproteinases in cancer progression
Egeblad, M., & Werb, Z. (2002) · Nature Reviews Cancer · doi:10.1038/nrc745 · Cited by 6,108
Matrix Metalloproteinases: Regulators of the Tumor Microenvironment
Kessenbrock, K., Plaks, V., & Werb, Z. (2010) · Cell · doi:10.1016/j.cell.2010.03.015 · Cited by 5,151
Cited by
Stimuli-responsive nanocarriers for drug delivery, tumor imaging, therapy and theranostics
Mi, P. (2020) · Theranostics · doi:10.7150/thno.38069 · Cited by 830
Recent progress in drug delivery
Li, C., Wang, J., Wang, Y., Gao, H., Wei, G., Huang, Y., Yu, H., Gan, Y., Wang, Y., Mei, L., et al. (2019) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2019.08.003 · Cited by 818
Tian, H., Zhang, T., Qin, S., Huang, Z., Zhou, L., Shi, J., Nice, E. C., Xie, N., Huang, C., & Shen, Z. (2022) · Journal of Hematology & Oncology · doi:10.1186/s13045-022-01320-5 · Cited by 426
Shao, J., Ruan, C., Xie, H., Li, Z., Wang, H., Chu, P. K., & Yu, X. (2018) · Advanced Science · doi:10.1002/advs.201700848 · Cited by 367
Dong, S., Dong, Y., Zhao, Z., Liu, J., Liu, S., Feng, L., He, F., Gai, S., Xie, Y., & Yang, P. (2023) · Journal of the American Chemical Society · doi:10.1021/jacs.2c09608 · Cited by 267
Metadata
- Authors
- Zhao, X., Yang, C.-X., Chen, L.-G., & Yan, X.-P.
- Venue
- Nature Communications
- Published
- 2017-05-19
- Volume
- 8
- Issue
- 1
- Pages
- 14998-14998
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2614666068
- Cited by
- 247
- References
- 2
- FWCI
- 13.27
- Type
- journal article
- Language
- en
- Open access
- gold
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- Zhao, X., Yang, C.-X., Chen, L.-G., & Yan, X.-P. (2017). Dual-stimuli responsive and reversibly activatable theranostic nanoprobe for precision tumor-targeting and fluorescence-guided photothermal therapy. Nature Communications. https://doi.org/10.1038/ncomms14998
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