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Overcoming the Bottleneck of the Enzymatic Cycle by Steric Frustration

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Multiple Unfolding Pathways of Leucine Binding Protein (LBP) Probed by Single-Molecule Force Spectroscopy (SMFS)

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The metastable states of proteins

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Studying the Structural Dynamics of Bipedal DNA Motors with Single-Molecule Fluorescence Spectroscopy

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Lipid-Protein Interplay in Dimerization of Juxtamembrane Domains of Epidermal Growth Factor Receptor

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Single Molecule Data Analysis: An Introduction

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Effect of ligand binding on a protein with a complex folding landscape

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Multidomain Protein Solves the Folding Problem by Multifunnel Combined Landscape: Theoretical Investigation of a Y-Family DNA Polymerase

Wang, Y., Chu, X., Suo, Z., Wang, E., & Wang, J. (2012) · Journal of the American Chemical Society · doi:10.1021/ja3045663 · Cited by 37 · see citing works

Chaperones Rescue Luciferase Folding by Separating Its Domains

Scholl, Z. N., Yang, W., & Marszałek, P. E. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.582049 · Cited by 34 · see citing works

Structural dynamics of membrane-protein folding from single-molecule FRET

Krainer, G., Keller, S., & Schlierf, M. (2019) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2019.05.025 · Cited by 31 · see citing works

Metal ion induced heterogeneity in RNA folding studied by smFRET

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Novel Liposome-Based Surface-Enhanced Raman Spectroscopy (SERS) Substrate

Lum, W., Bruzas, I., Gorunmez, Z., Unser, S., Beck, T. L., & Sagle, L. B. (2017) · The Journal of Physical Chemistry Letters · doi:10.1021/acs.jpclett.7b00694 · Cited by 31 · see citing works

Extracting Conformational Memory from Single-Molecule Kinetic Data

Pressé, S., Lee, J., & Dill, K. A. (2012) · The Journal of Physical Chemistry B · doi:10.1021/jp309420u · Cited by 31 · see citing works

Nanoscale devices for linkerless long-term single-molecule observation

Banterle, N., & Lemke, E. A. (2016) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2016.02.013 · Cited by 30 · see citing works

An Efficient Path Classification Algorithm Based on Variational Autoencoder to Identify Metastable Path Channels for Complex Conformational Changes

Qiu, Y., O’Connor, M. S., Xue, M., Liu, B., & Huang, X. (2023) · Journal of Chemical Theory and Computation · doi:10.1021/acs.jctc.3c00318 · Cited by 29 · see citing works

Efficient maximum likelihood parameterization of continuous-time Markov processes.

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Two states or not two states: Single-molecule folding studies of protein L

Aviram, H. Y., Pirchi, M., Barak, Y., Riven, I., & Haran, G. (2017) · The Journal of Chemical Physics · doi:10.1063/1.4997584 · Cited by 28 · see citing works

Manipulating the Folding Landscape of a Multidomain Protein

Kantaev, R., Riven, I., Goldenzweig, A., Barak, Y., Dym, O., Peleg, Y., Albeck, S., Fleishman, S. J., & Haran, G. (2018) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.8b04834 · Cited by 26 · see citing works

In the Multi-domain Protein Adenylate Kinase, Domain Insertion Facilitates Cooperative Folding while Accommodating Function at Domain Interfaces

Rao, V. V. H. G., & Gosavi, S. (2014) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1003938 · Cited by 26 · see citing works

Mapping an Equilibrium Folding Intermediate of the Cytolytic Pore Toxin ClyA with Single-Molecule FRET

Dingfelder, F., Benke, S., Nettels, D., & Schuler, B. (2018) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.8b07026 · Cited by 26 · see citing works

Enhanced spontaneous DNA twisting/bending fluctuations unveiled by fluorescence lifetime distributions promote mismatch recognition by the Rad4 nucleotide excision repair complex

Chakraborty, S., Steinbach, P. J., Paul, D., Mu, H., Broyde, S. B., Min, J., & Ansari, A. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx1216 · Cited by 25 · see citing works

Folding pathway of a discontinuous two-domain protein

Agam, G. N., Barth, A., & Lamb, D. C. (2024) · Nature Communications · doi:10.1038/s41467-024-44901-3 · Cited by 23 · see citing works

First passage, looping, and direct transition in expanding and narrowing tubes: Effects of the entropy potential

Berezhkovskii, A. M., Dagdug, L., & Bezrukov, S. M. (2017) · The Journal of Chemical Physics · doi:10.1063/1.4993129 · Cited by 23 · see citing works

Site-specific time-resolved FRET reveals local variations in the unfolding mechanism in an apparently two-state protein unfolding transition

Bhatia, S., Krishnamoorthy, G., & Udgaonkar, J. B. (2017) · Physical Chemistry Chemical Physics · doi:10.1039/c7cp06214a · Cited by 23 · see citing works

Ligand-bound glutamine binding protein assumes multiple metastable binding sites with different binding affinities

Zhang, L., Wu, S., Feng, Y., Wang, D., Jia, X., Liu, Z., Liu, J., & Wang, W. (2020) · Communications Biology · doi:10.1038/s42003-020-01149-z · Cited by 23 · see citing works

Integrating single-molecule spectroscopy and simulations for the study of intrinsically disordered proteins

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Endocytosis-Like Vesicle Fission Mediated by a Membrane-Expanding Molecular Machine Enables Virus Encapsulation for In Vivo Delivery

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Expression and purification of nuclease-free protocatechuate 3,4-dioxygenase for prolonged single-molecule fluorescence imaging

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Spectral rate theory for two-state kinetics

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Position-, disorder-, and salt-dependent diffusion in binding-coupled-folding of intrinsically disordered proteins

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Shedding Light on Protein Folding, Structural and Functional Dynamics by Single Molecule Studies

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Stable trapping of multiple proteins at physiological conditions using nanoscale chambers with macromolecular gates

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Correlated and Anticorrelated Domain Movement of Human Serum Albumin: A Peek into the Complexity of the Crowded Milieu

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Single vesicle biochips for ultra-miniaturized nanoscale fluidics and single molecule bioscience

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Gradual Folding of an Off-Pathway Molten Globule Detected at the Single-Molecule Level

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Analyzing the Dynamics of Single TBP-DNA-NC2 Complexes Using Hidden Markov Models

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Functional, pathogenic, and pharmacological roles of protein folding intermediates

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Trends in Single-Molecule Total Internal Reflection Fluorescence Imaging and Their Biological Applications with Lab-on-a-Chip Technology

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Exploring the top of the protein folding funnel by experiment

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Probing Single-Molecule Protein Spontaneous Folding–Unfolding Conformational Fluctuation Dynamics: The Multiple-State and Multiple-Pathway Energy Landscape

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Meandering Down the Energy Landscape of Protein Folding: Are We There Yet?

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Error-based Extraction of States and Energy Landscapes from Experimental Single-Molecule Time-Series

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Couplings between hierarchical conformational dynamics from multi-time correlation functions and two-dimensional lifetime spectra: Application to adenylate kinase

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Capturing the Mechanical Unfolding Pathway of a Large Protein with Coiled‐Coil Probes

Li, Q., Scholl, Z. N., & Marszałek, P. E. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201407211 · Cited by 17 · see citing works

Absolute absorption cross-section measurement of a submonolayer film on a silica microresonator

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High‐throughput single‐molecule studies of protein–DNA interactions

Robison, A. D., & Finkelstein, I. J. (2014) · FEBS Letters · doi:10.1016/j.febslet.2014.05.021 · Cited by 17 · see citing works

ARTICLE

Haran, G. (2016)

Manipulating the Folding Landscape of a Multidomain Protein

Kantaev, R., Riven, I., Goldenzweig, A., Barak, Y., Dym, O., Peleg, Y., Albeck, S., Fleishman, S. J., & Haran, G. (2018) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.8b04834 · Cited by 26 · see citing works

Two states or not two states: Single-molecule folding studies of protein L

Aviram, H. Y., Pirchi, M., Barak, Y., Riven, I., & Haran, G. (2017) · The Journal of Chemical Physics · doi:10.1063/1.4997584 · Cited by 28 · see citing works

Sub-Millisecond Unfolding Kinetic Spectra Reveals Intermediate Transitions

Sanabria, H., Hemmen, K., Rodnin, D., Rohrbeck, D., Adariani, S. R., Kühnemuth, R., & Seidel, C. A. M. (2016) · Biophysical Journal · doi:10.1016/j.bpj.2015.11.1006

Watching proteins fold one molecule at a time

Rhoades, E. R., Gussakovsky, E. E., & Haran, G. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2628068100 · Cited by 339 · see citing works