The DOI matches its Crossref record; 74 of the 74 references it cites were found in a registry or an index.
Plastic roles of pericytes in the blood–retinal barrier
Open accessAbstract
The blood–retinal barrier (BRB) consists of tightly interconnected capillary endothelial cells covered with pericytes and glia, but the role of the pericytes in BRB regulation is not fully understood. Here, we show that platelet-derived growth factor (PDGF)-B/PDGF receptor beta (PDGFRβ) signalling is critical in formation and maturation of BRB through active recruitment of pericytes onto growing retinal vessels. Impaired pericyte recruitment to the vessels shows multiple vascular hallmarks of diabetic retinopathy (DR) due to BRB disruption. However, PDGF-B/PDGFRβ signalling is expendable for maintaining BRB integrity in adult mice. Although selective pericyte loss in stable adult retinal vessels surprisingly does not cause BRB disintegration, it sensitizes retinal vascular endothelial cells (ECs) to VEGF-A, leading to upregulation of angiopoietin-2 (Ang2) in ECs through FOXO1 activation and triggering a positive feedback that resembles the pathogenesis of DR. Accordingly, either blocking Ang2 or activating Tie2 greatly attenuates BRB breakdown, suggesting potential therapeutic approaches to reduce retinal damages upon DR progression.
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Pericytes regulate the blood–brain barrier
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Pericytes are required for blood–brain barrier integrity during embryogenesis
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Blood-Brain Barrier: From Physiology to Disease and Back
Sweeney, M. D., Zhao, Z., Montagne, A., Nelson, A. R., & Zlokovic, B. V. (2019) · Physiological Reviews · doi:10.1152/physrev.00050.2017 · Cited by 2,312
Pathophysiology of diabetic retinopathy: The old and the new
Kusuhara, S., Fukushima, Y., Ogura, S., Inoue, N., & Uemura, A. (2018) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2018.0182 · Cited by 250
Pericytes regulate vascular immune homeostasis in the CNS
Török, O., Schreiner, B., Schaffenrath, J., Tsai, H.-C., Maheshwari, U., Stifter, S. A., Welsh, C., Amorim, A., Sridhar, S., Utz, S. G., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2016587118 · Cited by 166
Angiopoietin-2 exacerbates cardiac hypoxia and inflammation after myocardial infarction
Lee, S.-J., Lee, C.-K., Kang, S., Park, I., Kim, Y. H., Kim, S. K., Hong, S. P., Bae, H., He, Y., Kubota, Y., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci99659 · Cited by 164
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Metadata
- Authors
- Park, D. Y., Lee, J., Kim, J., Kim, K., Hong, S., Han, S., Kubota, Y., Augustin, H. G., Ding, L., Kim, J. W., Kim, H., He, Y., Adams, R. H., & Koh, G. Y.
- Venue
- Nature Communications
- Published
- 2017-05-16
- Volume
- 8
- Issue
- 1
- Pages
- 15296-15296
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2615239588
- Cited by
- 322
- References
- 74
- FWCI
- 11.07
- Type
- journal article
- Language
- en
- Open access
- gold
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- Park, D. Y., Lee, J., Kim, J., Kim, K., Hong, S., Han, S., Kubota, Y., Augustin, H. G., Ding, L., Kim, J. W., Kim, H., He, Y., Adams, R. H., & Koh, G. Y. (2017). Plastic roles of pericytes in the blood–retinal barrier. Nature Communications. https://doi.org/10.1038/ncomms15296
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