Basic and Therapeutic Aspects of Angiogenesis
Open accessAbstract
Blood vessels form extensive networks that nurture all tissues in the body. Abnormal vessel growth and function are hallmarks of cancer and ischemic and inflammatory diseases, and they contribute to disease progression. Therapeutic approaches to block vascular supply have reached the clinic, but limited efficacy and resistance pose unresolved challenges. Recent insights establish how endothelial cells communicate with each other and with their environment to form a branched vascular network. The emerging principles of vascular growth provide exciting new perspectives, the translation of which might overcome the current limitations of pro- and antiangiogenic medicine.
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ECM is essential for efficient delivery of growth factors for induction of blood vessel growth.
“These studies have also confirmed the essential role of the ECM for efficient delivery of growth factors for induction of blood vessel growth (141, 143).”
From Wound repair and regeneration: Mechanisms, signaling, and translation (2014) · cites this paper as [141]
Because of abnormally high and continuous expression levels of angiogenic factors in cancer, the vasculature becomes ill-defined; vessel wall unstable and highly permeable, architecture tortuous and irregularly shaped, and density increased.
“Because of the abnormally high and continuous expression levels of angiogenic factors in cancer, the vasculature becomes illdefined; the vessel wall is unstable and remains highly permeable, architecture of the vessel is tortuous and irregularly shaped, and the density of the vasculature is increased [50][51][52][53].”
From Cancer-on-chip models for metastasis: importance of the tumor microenvironment (2024) · cites this paper as [52]
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- Authors
- Potente, M., Gerhardt, H., & Carmeliet, P.
- Affiliations
- Goethe University Frankfurt (DE)
- Cancer Research UK (GB)
- KU Leuven (BE)
- Corresponding author
- Carmeliet, Peter
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2011-09
- Volume
- 146
- Issue
- 6
- Pages
- 873-887
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2074196937
- Cited by
- 2,771
- References
- 101
- Citations by year
- 2026: 113 · 2025: 147 · 2024: 194 · 2023: 173 · 2022: 221 · 2021: 258 · 2020: 242 · 2019: 224 · 2018: 179 · 2017: 215 · 2016: 174 · 2015: 188 · 2014: 188 · 2013: 149 · 2012: 97
- FWCI
- 12.77
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
- Funders
- Belgische Federale Overheidsdiensten
- Cancer Research UK
- Lister Institute of Preventive Medicine
- Deutsche Forschungsgemeinschaft
- Vlaamse regering
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Keywords
- angiogenesis, vascular network formation, endothelial cells, tumor angiogenesis, ischemic diseases, inflammatory diseases, anti-angiogenic therapy, treatment resistance, vascular development
- MeSH terms
- Animals, Blood Vessels, Humans, Inflammation, Neovascularization, Pathologic, Neovascularization, Physiologic, Angiogenesis Inhibitors, Endothelial Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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