The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Sulfhydration mediates neuroprotective actions of parkin
Open accessAbstract
Increases in S-nitrosylation and inactivation of the neuroprotective ubiquitin E3 ligase, parkin, in the brains of patients with Parkinson’s disease are thought to be pathogenic and suggest a possible mechanism linking parkin to sporadic Parkinson’s disease. Here we demonstrate that physiologic modification of parkin by hydrogen sulfide, termed sulfhydration, enhances its catalytic activity. Sulfhydration sites are identified by mass spectrometry analysis and are investigated by site-directed mutagenesis. Parkin sulfhydration is markedly depleted in the brains of patients with Parkinson’s disease, suggesting that this loss may be pathologic. This implies that hydrogen sulfide donors may be therapeutic. The gasotransmitter hydrogen sulfide signals by sulfide modification of target proteins. Vandiver and colleagues study the sulfhydration of parkin by hydrogen sulfide and find that sulfhydration stimulates its activity, and that this activity is reduced in patients with Parkinson’s disease.
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Cites
PARIS (ZNF746) Repression of PGC-1α Contributes to Neurodegeneration in Parkinson's Disease
Shin, J.-H., Ko, H. S., Kang, H., Lee, Y., Lee, Y.-I., Pletinkova, O., Troconso, J. C., Dawson, V. L., & Dawson, T. M. (2011) · Cell · doi:10.1016/j.cell.2011.02.010 · Cited by 953
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Self-citationThe Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease
Pickrell, A. M., & Youle, R. J. (2015) · Neuron · doi:10.1016/j.neuron.2014.12.007 · Cited by 2,310
Chemical Biology of H2S Signaling through Persulfidation
Filipovic, M. R., Zivanovic, J., Alvarez, B., & Banerjee, R. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00205 · Cited by 1,046
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Mishanina, T. V., Libiad, M., & Banerjee, R. (2015) · Nature Chemical Biology · doi:10.1038/nchembio.1834 · Cited by 615
Structure of Parkin Reveals Mechanisms for Ubiquitin Ligase Activation
Trempe, J.-F., Sauvé, V., Grenier, K., Seirafi, M., Tang, M. Y., Ménade, M., Al-Abdul-Wahid, S., Krett, J., Wong, K., Kozlov, G., et al. (2013) · Science · doi:10.1126/science.1237908 · Cited by 523
Metadata
- Authors
- Vandiver, M. S., Paul, B. D., Xu, R., Karuppagounder, S., Rao, F., Snowman, A. M., Seok Ko, H., Il Lee, Y., Dawson, V. L., Dawson, T. M., Sen, N., & Snyder, S. H.
- Venue
- Nature Communications
- Published
- 2013-03-27
- Volume
- 4
- Issue
- 1
- Pages
- 1626-1626
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W1975797060
- Cited by
- 343
- References
- 5
- FWCI
- 15.77
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Vandiver, M. S., Paul, B. D., Xu, R., Karuppagounder, S., Rao, F., Snowman, A. M., Seok Ko, H., Il Lee, Y., Dawson, V. L., Dawson, T. M., Sen, N., & Snyder, S. H. (2013). Sulfhydration mediates neuroprotective actions of parkin. Nature Communications. https://doi.org/10.1038/ncomms2623
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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