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Cited by 523

The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.

Structure of Parkin Reveals Mechanisms for Ubiquitin Ligase Activation

Trempe, Jean-François, Sauvé, Véronique, Grenier, Karl, Seirafi, Marjan, Tang, Matthew Y., Ménade, Marie, Al-Abdul-Wahid, Sameer, Krett, Jonathan, Wong, Kathy, Kozlov, Guennadi, Nagar, Bhushan, Fon, Edward A., Gehring, Kalle·2013·Science
DOI 10.1126/science.1237908
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Abstract

Parkin Enhanced?: Inactivation of parkin, an E3 ubiquitin ligase, is responsible for a familial form of Parkinson's disease and may be involved in sporadic forms as well. Trempe et al. (p. 1451 , published online 9 May) present the crystal structure of full-length parkin in an autoinhibited configuration. Guided by the structure, mutations were designed that activated parkin both in vitro and in cells. Because parkin is neuroprotective, the structure provides a framework for enhancing parkin function as a therapeutic strategy in Parkinson's disease.

Overview

Integrity signals

Registry

Crossref · 10.1126/science.1237908

Cites

8 of 8 references verified0 citation errors · 0 not checkable

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Verification

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Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • USP8 deubiquitinating activity is specific toward parkin, as it was much less efficient at deubiquitinating other E3s, including HHARI.

    “The DUB activity of USP8 appeared to be specific toward parkin, as it was much less efficient at deubiquitinating other E3s, including HHARI, an RBR family E3 Ub-ligase structurally very similar to parkin (Fig 3D) (Duda et al, 2013;Trempe et al, 2013).”

    From USP8 regulates mitophagy by removing K6‐linked ubiquitin conjugates from parkin (2014) · cites this paper as Trempe et al, 2013

  • Parkin activity is auto-inhibited at baseline.

    “However, parkin activity is auto-inhibited at baseline (Trempe et al, 2013;Wauer & Komander, 2013), and understanding how PINK1-mediated phosphorylation of Ub and parkin triggers its activation and recruitment to mitochondria is incomplete (Kondapalli et al, 2012;Kane et al, 2014;Kazlauskaite et al, 2014;Koyano et al, 2014).”

    From USP8 regulates mitophagy by removing K6‐linked ubiquitin conjugates from parkin (2014) · cites this paper as Trempe et al, 2013

Citations

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Research works printed but not linked: 32

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  24. A. G. W. Leslie H. R. Powell in Evolving Methods for Macromolecular Crystallography R. J. Read J. L. Sussman Eds. (Springer New York 2007) pp. 41–51. · DOI
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Metadata

Authors
Trempe, J.-F., Sauvé, V., Grenier, K., Seirafi, M., Tang, M. Y., Ménade, M., Al-Abdul-Wahid, S., Krett, J., Wong, K., Kozlov, G., Nagar, B., Fon, E. A., & Gehring, K.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
2013-06-21
Volume
340
Issue
6139
Pages
1451-1455
ISSN
  • 0036-8075
  • 1095-9203
DOI
10.1126/science.1237908
Cited by
523
References
8
Language
en

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