A double‐blind, placebo‐controlled study to assess the mitochondria‐targeted antioxidant MitoQ as a disease‐modifying therapy in Parkinson's disease
Abstract
Multiple lines of evidence point to mitochondrial oxidative stress as a potential pathogenic cause for Parkinson's disease (PD). MitoQ is a powerful mitochondrial antioxidant. It is absorbed orally and concentrates within mitochondria where it has been shown to protect against oxidative damage. We enrolled 128 newly diagnosed untreated patients with PD in a double‐blind study of two doses of MitoQ compared with placebo to explore the hypothesis that, over 12 months, MitoQ would slow the progression of PD as measured by clinical scores, particularly the Unified Parkinson Disease Rating Scale. We showed no difference between MitoQ and placebo on any measure of PD progression. MitoQ does not slow the progression of PD, and this finding should be taken into account when considering the oxidative stress hypothesis for the pathogenesis of PD. © 2010 Movement Disorder Society
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MitoQ has been through two phase II trials for other conditions.
“MitoQ has been though two phase II trials for other conditions”
From The mitochondria-targeted antioxidant MitoQ prevents loss of spatial memory retention and early neuropathology in a transgenic mouse model of Alzheimer’s disease (2011) · cites this paper as Snow et al., 2010
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- Authors
- Snow, B. J., Rolfe, F. L., Lockhart, M. M., Frampton, C. M., O'Sullivan, J. D., Fung, V., Smith, R. A. J., Murphy, M. P., Taylor, K. M., & On behalf of the Protect Study Group
- Affiliations
- Auckland District Health Board (NZ)
- Christchurch Hospital (NZ)
- The University of Sydney (AU)
- University of Otago (NZ)
- MRC Mitochondrial Biology Unit (GB)
- Corresponding author
- Snow, Barry J.
- Venue
- Movement Disorders
- Publisher
- Wiley
- Published
- 2010-08-15
- Volume
- 25
- Issue
- 11
- Pages
- 1670-1674
- ISSN
- 0885-3185 (ISSN-L)
- 1531-8257
- OpenAlex
- W2020585998
- Cited by
- 606
- References
- 5
- Citations by year
- 2026: 44 · 2025: 44 · 2024: 35 · 2023: 48 · 2022: 48 · 2021: 39 · 2020: 79 · 2019: 23 · 2018: 43 · 2017: 35 · 2016: 38 · 2015: 30 · 2014: 22 · 2013: 26 · 2012: 28
- FWCI
- 14.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Movement Disorders (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Keywords
- MitoQ, Parkinson's disease, mitochondrial antioxidants, mitochondrial oxidative stress, disease-modifying therapy, disease progression, Unified Parkinson's Disease Rating Scale, oxidative stress hypothesis
- MeSH terms
- Adult, Aged, Antioxidants, Dose-Response Relationship, Drug, Double-Blind Method, Female, Humans, Male, Middle Aged, Organophosphorus Compounds, Parkinson Disease, Time Factors, Ubiquinone, Treatment Outcome
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