Biomaterials and emerging anticancer therapeutics: engineering the microenvironment
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The microenvironment is increasingly recognized to have key roles in cancer, and biomaterials provide a means to engineer microenvironments both in vitro and in vivo to study and manipulate cancer. In vitro cancer models using 3D matrices recapitulate key elements of the tumour microenvironment and have revealed new aspects of cancer biology. Cancer vaccines based on some of the same biomaterials have, in parallel, allowed for the engineering of durable prophylactic and therapeutic anticancer activity in preclinical studies, and some of these vaccines have moved to clinical trials. The impact of biomaterials engineering on cancer treatment is expected to further increase in importance in the years to come.
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Introduction of 3D cell culture approaches aimed at modeling in vivo interactions of tissues and organs has opened new possibilities in studying underlying biochemical and biomechanical signals.
“The introduction of 3D cell culture approaches aimed at modeling the in vivo interactions of tissues and organs has opened new possibilities in studying the underlying biochemical and biomechanical signals (46,57).”
From Modeling physiological events in 2D vs. 3D cell culture (2017) · cites this paper as [46]
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3D Bioprinting of Tumor Models for Cancer Research
Kang, Y., Datta, P., Shanmughapriya, S., & Ozbolat, I. T. (2020) · ACS Applied Bio Materials · doi:10.1021/acsabm.0c00791 · Cited by 112 · see citing works
Delivery Strategies for Immune Checkpoint Blockade
Chen, Q., Wang, C., Chen, G., Hu, Q., & Gu, Z. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201800424 · Cited by 90 · see citing works
Dynamic Microenvironment Induces Phenotypic Plasticity of Esophageal Cancer Cells Under Flow
Calibasi Kocal, G., Güven, S., Foygel, K., Goldman, A., Chen, P., Sengupta, S., Paulmurugan, R., Baskin, Y., & Demirci, U. (2016) · Scientific Reports · doi:10.1038/srep38221 · Cited by 52 · see citing works
- Authors
- Gu, L., & Mooney, D. J.
- Affiliations
- Harvard University (US)
- Corresponding author
- Mooney, David J.
- Venue
- Nature Reviews Cancer
- Published
- 2015-12-23
- Volume
- 16
- Issue
- 1
- Pages
- 56-66
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- PMC
- PMC4790726
- OpenAlex
- W2208179253
- Cited by
- 407
- References
- 186
- Citations by year
- 2026: 11 · 2025: 20 · 2024: 28 · 2023: 38 · 2022: 42 · 2021: 66 · 2020: 49 · 2019: 36 · 2018: 51 · 2017: 43 · 2016: 23
- FWCI
- 2.72
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Cancer (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- Funders
- National Institute of Biomedical Imaging and Bioengineering (R01EB015498)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- biomaterials engineering, tumor microenvironment, cancer immunotherapy, 3D cell culture models, cancer vaccines, tumor biology, anticancer agents, bioengineering
- MeSH terms
- Biocompatible Materials, Humans, Neoplasms, Tissue Engineering, Tumor Microenvironment
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