Cited by 407Hydrogels: synthesis, properties, applications3D Printing in Biomedical ResearchImmunotherapy and Immune Responses

Biomaterials and emerging anticancer therapeutics: engineering the microenvironment

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Gu, Luo, Mooney, David J.·2016·Nature Reviews Cancer

Abstract

The microenvironment is increasingly recognized to have key roles in cancer, and biomaterials provide a means to engineer microenvironments both in vitro and in vivo to study and manipulate cancer. In vitro cancer models using 3D matrices recapitulate key elements of the tumour microenvironment and have revealed new aspects of cancer biology. Cancer vaccines based on some of the same biomaterials have, in parallel, allowed for the engineering of durable prophylactic and therapeutic anticancer activity in preclinical studies, and some of these vaccines have moved to clinical trials. The impact of biomaterials engineering on cancer treatment is expected to further increase in importance in the years to come.

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  • Introduction of 3D cell culture approaches aimed at modeling in vivo interactions of tissues and organs has opened new possibilities in studying underlying biochemical and biomechanical signals.

    “The introduction of 3D cell culture approaches aimed at modeling the in vivo interactions of tissues and organs has opened new possibilities in studying the underlying biochemical and biomechanical signals (46,57).”

    From Modeling physiological events in 2D vs. 3D cell culture (2017) · cites this paper as [46]

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Authors
Gu, L., & Mooney, D. J.
Affiliations
Harvard University (US)
Corresponding author
Mooney, David J.
Venue
Nature Reviews Cancer
Published
2015-12-23
Volume
16
Issue
1
Pages
56-66
ISSN
  • 1474-175X (ISSN-L)
  • 1474-1768
OpenAlex
W2208179253
Cited by
407
References
186
Citations by year
2026: 11 · 2025: 20 · 2024: 28 · 2023: 38 · 2022: 42 · 2021: 66 · 2020: 49 · 2019: 36 · 2018: 51 · 2017: 43 · 2016: 23
FWCI
2.72
Type
journal article
Language
en
Open access
Locations
  • Nature reviews. Cancer (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
Funders
National Institute of Biomedical Imaging and Bioengineering (R01EB015498)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords
biomaterials engineering, tumor microenvironment, cancer immunotherapy, 3D cell culture models, cancer vaccines, tumor biology, anticancer agents, bioengineering
MeSH terms
Biocompatible Materials, Humans, Neoplasms, Tissue Engineering, Tumor Microenvironment

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