The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Tumour angiogenesis regulation by the miR-200 family
Open accessAbstract
The miR-200 family is well known to inhibit the epithelial–mesenchymal transition, suggesting it may therapeutically inhibit metastatic biology. However, conflicting reports regarding the role of miR-200 in suppressing or promoting metastasis in different cancer types have left unanswered questions. Here we demonstrate a difference in clinical outcome based on miR-200’s role in blocking tumour angiogenesis. We demonstrate that miR-200 inhibits angiogenesis through direct and indirect mechanisms by targeting interleukin-8 and CXCL1 secreted by the tumour endothelial and cancer cells. Using several experimental models, we demonstrate the therapeutic potential of miR-200 delivery in ovarian, lung, renal and basal-like breast cancers by inhibiting angiogenesis. Delivery of miR-200 members into the tumour endothelium resulted in marked reductions in metastasis and angiogenesis, and induced vascular normalization. The role of miR-200 in blocking cancer angiogenesis in a cancer-dependent context defines its utility as a potential therapeutic agent. The microRNA-200 family members have a role in regulating tumour angiogenesis but the underlying mechanism is unclear. In this study, Pecot et al.demonstrate that miR-200 affects angiogenesis by altering endothelial and cancer cell cytokine secretion.
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Self-citationChronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma
Thaker, P. H., Han, L. Y., Kamat, A. A., Arevalo, J. M., Takahashi, R., Lu, C., Jennings, N. B., Armaiz-Pena, G., Bankson, J. A., Ravoori, M., et al. (2006) · Nature Medicine · doi:10.1038/nm1447 · Cited by 1,320
Self-citationA CXCL1 Paracrine Network Links Cancer Chemoresistance and Metastasis
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Rupaimoole, R., & Slack, F. J. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.246 · Cited by 4,741
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Nucleic acid delivery for therapeutic applications
Gupta, A., Andresen, J. L., Manan, R. S., & Langer, R. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.113834 · Cited by 331
The Roles of MicroRNA in Lung Cancer
Wu, K.-L., Tsai, Y.-M., Lien, C.-T., Kuo, P.-L., & Hung, J.-Y. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20071611 · Cited by 284
Emerging role of tumor cell plasticity in modifying therapeutic response
Qin, S., Jiang, J., Lu, Y., Nice, E. C., Huang, C., Zhang, J., & He, W. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00313-5 · Cited by 268
Metadata
- Authors
- Pecot, C. V., Rupaimoole, R., Yang, D., Akbani, R., Ivan, C., Lu, C., Wu, S., Han, H.-D., Shah, M. Y., Rodriguez-Aguayo, C., Bottsford-Miller, J., Liu, Y., Kim, S. B., Unruh, A., Gonzalez-Villasana, V., Huang, L., Zand, B., Moreno-Smith, M., Mangala, L. S., Taylor, M., Dalton, H. J., Sehgal, V., Wen, Y., Kang, Y., Baggerly, K. A., Lee, J.-S., Ram, P. T., Ravoori, M. K., Kundra, V., Zhang, X., Ali-Fehmi, R., Gonzalez-Angulo, A.-M., Massion, P. P., Calin, G. A., Lopez-Berestein, G., Zhang, W., & Sood, A. K.
- Venue
- Nature Communications
- Published
- 2013-09-10
- Volume
- 4
- Issue
- 1
- Pages
- 2427-2427
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2007881573
- Cited by
- 402
- References
- 8
- FWCI
- 13.66
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Tumour angiogenesis regulation by the miR-200 family. https://app.cochat.ai/papers/10.1038/ncomms3427
- The paper
- Pecot, C. V., Rupaimoole, R., Yang, D., Akbani, R., Ivan, C., Lu, C., Wu, S., Han, H.-D., Shah, M. Y., Rodriguez-Aguayo, C., Bottsford-Miller, J., Liu, Y., Kim, S. B., Unruh, A., Gonzalez-Villasana, V., Huang, L., Zand, B., Moreno-Smith, M., Mangala, L. S., . . . Sood, A. K. (2013). Tumour angiogenesis regulation by the miR-200 family. Nature Communications. https://doi.org/10.1038/ncomms3427
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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