Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology

Mederacke, Ingmar, Hsu, Christine C., Troeger, Juliane S., Huebener, Peter, Mu, Xueru, Dapito, Dianne H., Pradere, Jean-Philippe, Schwabe, Robert F.·2013·Nature Communications

DOI 10.1038/ncomms3823

Cited by (1,001)

Items 601–700 of 1,001

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Hongjun Zhang, Baoling Ju, Xiaoli Zhang, Yanfei Zhu, Ying Nie, Yuanhong Xu, Qiuxia Lei · 2016 · Basic & Clinical Pharmacology & Toxicology
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Erawan Borkham‐Kamphorst, Bettina Therese Steffen, Eddy Van de Leur, Ute Haas, Ralf Weiskirchen · 2018 · Cellular Signalling
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Mirko Manetti, Eloisa Romano, Irene Rosa, Bianca Saveria Fioretto, Emanuela Praino, Serena Guiducci, Florenzo Iannone, Lidia Ibba‐Manneschi, Marco Matucci‐Cerinic · 2019 · Journal of Clinical Medicine
Mechanisms of hepatic stellate cell activation as a therapeutic target for the treatment of non-alcoholic steatohepatitis
Takuma Tsuchida · 2019 · Folia Pharmacologica Japonica
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David Højland Ipsen, Pernille Tveden‐Nyborg · 2021 · Biomedicines
Vitamin E pretreated Wharton’s jelly-derived mesenchymal stem cells attenuate CCl4-induced hepatocyte injury in vitro and liver fibrosis in vivo
Maria Tayyab Baig, Hafiz Ghufran, Azra Mehmood, Maryam Azam, Shamsa Humayun, Sheikh Amer Riazuddin · 2021 · Biochemical Pharmacology
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Olga Zbodakova, Karel Chalupský, Jolana Turečková, Radislav Sedláček · 2017 · Metalloproteinases In Medicine
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Feifan Xu, Sidan Lu, Xin Jia, Yajun Zhou · 2023 · Toxicology Letters
Metastasis ‘systems’ biology: how are macro-environmental signals transmitted into microenvironmental cues for disseminated tumor cells?
Candice Alexandra Grzelak, Cyrus Michael Ghajar · 2017 · Current Opinion in Cell Biology
Mesenchymal perivascular cells in immunity and disease
Adam Benabid, Lucie Peduto · 2020 · Current Opinion in Immunology
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Jing Chen, Si-Jia Ge, Hai-Juan Feng, Shu-Zhen Wu, Ran Ji, Wei-Rong Huang, Wei Huang, Cui-Hua Lu · 2021 · Journal of Clinical and Translational Hepatology
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Somayeh Mahdinloo, Salar Hemmati, Hadi Valizadeh, Mohammad Mahmoudian, Javad Mahmoudi, Leyla Roshangar, Muhammad Sarfraz, Parvin Zakeri‐Milani · 2022 · International Journal of Pharmaceutics
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Kyounghee Min, Batuhan Yenilmez, Mark Kelly, Dimas Echeverria, Michael Elleby, Lawrence M. Lifshitz, Naideline Raymond, Emmanouela Tsagkaraki, Shauna M. Harney, Chloe DiMarzio et al. · 2023 · eLife
Stem cell heterogeneity, plasticity, and regulation
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Moritz J. Strowitzki, Johanna Kirchberg, Christopher Tuffs, Maximilian Schiedeck, Alina S. Ritter, Marvin Biller, Jonathan M. Harnoss, Felix Lasitschka, Thomas Schmidt, Praveen Radhakrishnan et al. · 2018 · American Journal Of Pathology
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Lei Peng, George O. Agogo, Jianqiang Guo, Ming Yan · 2019 · Neuropeptides
The multi-faceted immune modulatory role of S100A4 in cancer and chronic inflammatory disease
Thomas K. S. Wong, Reece Kang, Kyuson Yun · 2025 · Frontiers in Immunology
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Hao Xiong, Guo J · 2025 · Pharmaceuticals
Biomimetic nanoparticles for targeted therapy of liver disease
Veena Vijayan, Janitha M. Unagolla, Dhruvisha Panchal, Judith E. Okoh, Siddharth S. Menon, Jyothi U. Menon · 2025 · RSC Pharmaceutics
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Qing Zhou, Tengfei Gu, Yong Zhang, Hongda Li, Xue-Mei ZhuanSun, Sanrong Xu, Yuting Kuang · 2021 · BioMed Research International
Role of Innate lymphoid Cells in Obesity and Insulin Resistance
Hong Chen, Lijun Sun, Lu Feng, Yue Yin, Weizhen Zhang · 2022 · Frontiers in Endocrinology
The New Paradigm of Non-Alcoholic Fatty Liver Disease: Phenotypic Diversity of Metabolically Associated Fatty Liver Disease
Ye.V. Vinnitskaya, Yu.G. Sandler, Dmitry S. Bordin · 2020 · Effective Pharmacotherapy
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Cristina Ortiz, Sabine Klein, Winfried Reul, Fernando Magdaleno, Stefanie Gröschl, Peter Dietrich, Robert Schierwagen, Frank Erhard Uschner, Sandra Torres, Christoph Hieber et al. · 2023 · Cell Reports
The total polyphenolic glycoside extract of Lamiophlomis rotata ameliorates hepatic fibrosis through apoptosis by TGF-β/Smad signaling pathway
Guoguo Wan, Zhiwei Chen, Lei Lei, Xiaoyu Geng, Yi Zhang, Congwen Yang, Wenfu Cao, Zheng Pan · 2023 · Chinese Medicine
Liver sinusoidal endothelial S1pr2 regulates experimental liver fibrosis through YAP / TGF ‐β signaling pathway
Yang Liao, Caixia Zhou, Yunhao Duan, Xiuxiang Liu, Jinnan Yue, Xiufen Li, Jinjin Wu, Chaomin Wan, Lin Zhang · 2023 · The FASEB Journal
Artemisia argyi ethanol extract ameliorates nonalcoholic steatohepatitis-induced liver fibrosis by modulating gut microbiota and hepatic signaling
Saruul Erdenebileg, Myungsuk Kim, Yunseong Nam, Kwang Hyun, Tam Thi Le, Sang Hoon Jung, Chu Won Nho · 2024 · Journal of Ethnopharmacology
New Biomarkers in Liver Fibrosis: A Pass through the Quicksand?
Marzia Tagliaferro, Mariapaola Marino, Valerio Basile, Krizia Pocino, Gian Ludovico Rapaccini, Gabriele Ciasca, Umberto Basile, Valeria Carnazzo · 2024 · Journal of Personalized Medicine
Trajectory analysis of hepatic stellate cell differentiation reveals metabolic regulation of cell commitment and fibrosis
Raquel A. Martínez García de la Torre, Júlia Vallverdú, Zhixin Xu, Sílvia Ariño, Raquel Ferrer‐Lorente, Laura Zanatto, María Mercado-Gómez, Beatriz Aguilar‐Bravo, Paloma Ruiz-Blázquez, M. Guadalupe Fernández et al. · 2025 · Nature Communications
Inhibitory effect of dietary capsaicin on liver fibrosis in mice
Shanna Bitencourt, Leslie Stradiot, Stefaan Verhulst, Lien F.R. Thoen, Inge Mannaerts, Leo A. van Grunsven · 2015 · Molecular Nutrition & Food Research
Role of CTGF gene promoter methylation in the development of hepatic fibrosis.
Cuicui Shi, Guangming Li, Yao Tong, Yilin Deng, Jian‐Gao Fan · 2016 · Europe PMC (PubMed Central)
Platelet-derived growth factor receptor α in hepatocellular carcinoma is a prognostic marker independent of underlying liver cirrhosis
Jung Hwan Yu, Joon Mee Kim, Ja Kyung Kim, Suk Jin Choi, Kwan Sik Lee, Jung Il Lee, Hye Young Chang, Jung Il Lee · 2017 · Oncotarget