Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology
Mederacke, Ingmar, Hsu, Christine C., Troeger, Juliane S., Huebener, Peter, Mu, Xueru, Dapito, Dianne H., Pradere, Jean-Philippe, Schwabe, Robert F.·2013·Nature Communications
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- Hepatic progenitor cells in liver regeneration: current advances and clinical perspectivesAezam Katoonizadeh, Hossein Poustchi, Reza Malekzadeh · 2014 · Liver International
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