The DOI matches its Crossref record; 69 of the 69 references it cites were found in a registry or an index.
In vivo conversion of astrocytes to neurons in the injured adult spinal cord
Open accessAbstract
Spinal cord injury (SCI) leads to irreversible neuronal loss and glial scar formation, which ultimately result in persistent neurological dysfunction. Cellular regeneration could be an ideal approach to replenish the lost cells and repair the damage. However, the adult spinal cord has limited ability to produce new neurons. Here we show that resident astrocytes can be converted to doublecortin (DCX)-positive neuroblasts by a single transcription factor, SOX2, in the injured adult spinal cord. Importantly, these induced neuroblasts can mature into synapse-forming neurons in vivo. Neuronal maturation is further promoted by treatment with a histone deacetylase inhibitor, valproic acid (VPA). The results of this study indicate that in situ reprogramming of endogenous astrocytes to neurons might be a potential strategy for cellular regeneration after SCI. Expression of the transcription factor SOX2 reprogrammes astrocytes into neuroblasts in the adult mouse striatum. Here, the authors use the same approach in the injured adult mouse spinal cord to convert resident astrocytes into neuroblasts that can mature into synapse-forming neurons.
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Cited by
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BackgroundDirect cell reprogramming: approaches, mechanisms and progress
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Revisiting astrocyte to neuron conversion with lineage tracing in vivo
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Self-citation2D Laminar Membranes for Selective Water and Ion Transport
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Sox2-mediated conversion of NG2 glia into induced neurons in the injured adult cerebral cortex
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Metadata
- Authors
- Su, Z., Niu, W., Liu, M.-L., Zou, Y., & Zhang, C.-L.
- Venue
- Nature Communications
- Published
- 2014-02-25
- Volume
- 5
- Issue
- 1
- Pages
- 3338-3338
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2074131381
- Cited by
- 416
- References
- 69
- FWCI
- 13.27
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Su, Z., Niu, W., Liu, M.-L., Zou, Y., & Zhang, C.-L. (2014). In vivo conversion of astrocytes to neurons in the injured adult spinal cord. Nature Communications. https://doi.org/10.1038/ncomms4338
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