Cited by 792Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene RegulationNeuroinflammation and Neurodegeneration Mechanisms

Adult Mammalian Neural Stem Cells and Neurogenesis: Five Decades Later

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Bond, Allison M., Ming, Guo-li, Song, Hongjun·2015·Cell Stem Cell

Abstract

Adult somatic stem cells in various organs maintain homeostatic tissue regeneration and enhance plasticity. Since its initial discovery five decades ago, investigations of adult neurogenesis and neural stem cells have led to an established and expanding field that has significantly influenced many facets of neuroscience, developmental biology, and regenerative medicine. Here we review recent progress and focus on questions related to adult mammalian neural stem cells that also apply to other somatic stem cells. We further discuss emerging topics that are guiding the field toward better understanding adult neural stem cells and ultimately applying these principles to improve human health.

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Crossref · 10.1016/j.stem.2015.09.003

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Authors
Bond, A. M., Ming, G.-L., & Song, H.
Affiliations
Johns Hopkins University (US)
Corresponding author
Song, Hongjun
Venue
Cell Stem Cell
Publisher
Elsevier BV
Published
2015-10
Volume
17
Issue
4
Pages
385-395
ISSN
  • 1875-9777 (ISSN-L)
  • 1934-5909
OpenAlex
W1828558002
Cited by
791
References
113
Citations by year
2026: 41 · 2025: 61 · 2024: 68 · 2023: 76 · 2022: 74 · 2021: 105 · 2020: 90 · 2019: 93 · 2018: 67 · 2017: 67 · 2016: 43 · 2015: 4 · 2014: 1
FWCI
7.53
Type
journal article
Language
en
Open access
Locations
  • Cell stem cell (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of Mental Health (MH105128, R01MH105128)
  • National Institute of Neurological Disorders and Stroke (NS 048271, R01NS047344, NS 047344, R01NS048271, R21NS093772, R37NS047344, NS093772, NS09538, R56NS047344)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
adult neural stem cells, adult neurogenesis, adult stem cells, tissue regeneration, stem cell plasticity, regenerative medicine, stem cell niche
MeSH terms
Adult, Animals, Homeostasis, Humans, Regenerative Medicine, Adult Stem Cells, Neurogenesis, Neural Stem Cells

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