Adult Mammalian Neural Stem Cells and Neurogenesis: Five Decades Later
Open accessAbstract
Adult somatic stem cells in various organs maintain homeostatic tissue regeneration and enhance plasticity. Since its initial discovery five decades ago, investigations of adult neurogenesis and neural stem cells have led to an established and expanding field that has significantly influenced many facets of neuroscience, developmental biology, and regenerative medicine. Here we review recent progress and focus on questions related to adult mammalian neural stem cells that also apply to other somatic stem cells. We further discuss emerging topics that are guiding the field toward better understanding adult neural stem cells and ultimately applying these principles to improve human health.
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Radial glial cells, stem cell precursors, and astrocytes all express GFAP and are found in the dentate gyrus.
“Radial glial cells, stem cell precursors, and astrocytes - all reported to express GFAP (reviewed in ref.26) - are found in the dentate gyrus2,27,28.”
From Therapeutically viable generation of neurons with antisense oligonucleotide suppression of PTB (2021) · cites this paper as [2]
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Radial glial cells in the adult dentate gyrus: what are they and where do they come from?
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Reviewing the Role of the Endocannabinoid System in the Pathophysiology of Depression
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The spinal ependymal zone as a source of endogenous repair cells across vertebrates
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CTNNB1 in neurodevelopmental disorders
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Modeling synaptogenesis in schizophrenia and autism using human iPSC derived neurons
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Metabolic regulation of neurodifferentiation in the adult brain
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- Authors
- Bond, A. M., Ming, G.-L., & Song, H.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Song, Hongjun
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2015-10
- Volume
- 17
- Issue
- 4
- Pages
- 385-395
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- PMC
- PMC4683085
- OpenAlex
- W1828558002
- Cited by
- 791
- References
- 113
- Citations by year
- 2026: 41 · 2025: 61 · 2024: 68 · 2023: 76 · 2022: 74 · 2021: 105 · 2020: 90 · 2019: 93 · 2018: 67 · 2017: 67 · 2016: 43 · 2015: 4 · 2014: 1
- FWCI
- 7.53
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell stem cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (MH105128, R01MH105128)
- National Institute of Neurological Disorders and Stroke (NS 048271, R01NS047344, NS 047344, R01NS048271, R21NS093772, R37NS047344, NS093772, NS09538, R56NS047344)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- adult neural stem cells, adult neurogenesis, adult stem cells, tissue regeneration, stem cell plasticity, regenerative medicine, stem cell niche
- MeSH terms
- Adult, Animals, Homeostasis, Humans, Regenerative Medicine, Adult Stem Cells, Neurogenesis, Neural Stem Cells
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