The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
The actin homologue MreB organizes the bacterial cell membrane
Open accessAbstract
The eukaryotic cortical actin cytoskeleton creates specific lipid domains, including lipid rafts, which determine the distribution of many membrane proteins. Here we show that the bacterial actin homologue MreB displays a comparable activity. MreB forms membrane-associated filaments that coordinate bacterial cell wall synthesis. We noticed that the MreB cytoskeleton influences fluorescent staining of the cytoplasmic membrane. Detailed analyses combining an array of mutants, using specific lipid staining techniques and spectroscopic methods, revealed that MreB filaments create specific membrane regions with increased fluidity (RIFs). Interference with these fluid lipid domains (RIFs) perturbs overall lipid homeostasis and affects membrane protein localization. The influence of MreB on membrane organization and fluidity may explain why the active movement of MreB stimulates membrane protein diffusion. These novel MreB activities add additional complexity to bacterial cell membrane organization and have implications for many membrane-associated processes.
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Cites
Membrane lipid homeostasis in bacteria
Zhang, Y.-M., & Rock, C. O. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1839 · Cited by 1,393 · cited 1×
“These distinct membrane configurations are predominantly determined by the fatty acid moiety of the lipids 29,30 .”
Spectrofluorometric studies of the lipid probe, nile red.
Greenspan, P., & Fowler, S. D. (1985) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)34307-8 · Cited by 980
Cited by
Daptomycin inhibits cell envelope synthesis by interfering with fluid membrane microdomains
Müller, A., Wenzel, M., Strahl, H., Grein, F., Saaki, T. N. V., Kohl, B., Siersma, T., Bandow, J. E., Sahl, H.-G., Schneider, T., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1611173113 · Cited by 425
Self-citationAnalysis of Antimicrobial-Triggered Membrane Depolarization Using Voltage Sensitive Dyes
te Winkel, J. D., Gray, D. A., Seistrup, K. H., Hamoen, L. W., & Strahl, H. (2016) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2016.00029 · Cited by 326
Self-citationMembrane-partitioned cell wall synthesis in mycobacteria
García-Heredia, A., Kado, T., Sein, C. E., Puffal, J., Osman, S. H., Judd, J., Gray, T. A., Morita, Y. S., & Siegrist, M. S. (2021) · eLife · doi:10.7554/elife.60263 · Cited by 44
Tödter, D., Gunka, K., & Stülke, J. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00883 · Cited by 22
MreB: unraveling the molecular mechanisms of bacterial shape, division, and environmental adaptation
Wang, Y., jiang, Y., Song, Z., Zhu, C., Tang, Y., Peng, J., & Liu, P. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02373-y · Cited by 12
Metadata
- Authors
- Strahl, H., Bürmann, F., & Hamoen, L. W.
- Venue
- Nature Communications
- Published
- 2014-03-07
- Volume
- 5
- Issue
- 1
- Pages
- 3442-3442
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2143279660
- Cited by
- 238
- References
- 2
- FWCI
- 8.64
- Type
- journal article
- Language
- en
- Open access
- hybrid
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