The DOI matches its Crossref record; 100 of the 100 references it cites were found in a registry or an index.
Daptomycin inhibits cell envelope synthesis by interfering with fluid membrane microdomains
Open accessAbstract
Significance: To date, simple membrane pore formation resulting in cytoplasmic leakage is the prevailing model for how membrane-active antibiotics kill bacteria and also is one of the main explanations for the activity of the membrane-binding antibiotic daptomycin. However, such models, typically derived from model membrane studies, often depict membranes as homogenous lipid bilayers. They do not take into account the complex architecture of biological membranes, with their many different membrane proteins, or the presence of microdomains with different fluidity properties. Here we report that daptomycin perturbs fluid microdomains in bacterial cell membranes, thereby interfering with membrane-bound cell wall and lipid synthesis processes. Our results add a different perspective as to how membrane-active antibiotics can kill bacteria.
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Cites
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Structural and mechanistic insights into fungal β-1,3-glucan synthase FKS1
Hu, X., Yang, P., Chai, C., Liu, J., Sun, H., Wu, Y., Zhang, M., Zhang, M., Liu, X., & Yu, H. (2023) · Nature · doi:10.1038/s41586-023-05856-5 · Cited by 213
CDP-Diacylglycerol Synthases (CDS): Gateway to Phosphatidylinositol and Cardiolipin Synthesis
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Toxicity of UV filters on marine bacteria: Combined effects with damaging solar radiation
Lozano, C., Matallana-Surget, S., Givens, J., Nouet, S., Arbuckle, L., Lambert, Z., & Lebaron, P. (2020) · Science of The Total Environment · doi:10.1016/j.scitotenv.2020.137803 · Cited by 54
Metadata
- Authors
- Müller, A., Wenzel, M., Strahl, H., Grein, F., Saaki, T. N. V., Kohl, B., Siersma, T., Bandow, J. E., Sahl, H.-G., Schneider, T., & Hamoen, L. W.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2016-10-24
- Volume
- 113
- Issue
- 45
- Pages
- E7077-E7086
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2537852878
- Cited by
- 425
- References
- 100
- FWCI
- 17.15
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Müller, A., Wenzel, M., Strahl, H., Grein, F., Saaki, T. N. V., Kohl, B., Siersma, T., Bandow, J. E., Sahl, H.-G., Schneider, T., & Hamoen, L. W. (2016). Daptomycin inhibits cell envelope synthesis by interfering with fluid membrane microdomains. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1611173113
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