The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Integrating artificial with natural cells to translate chemical messages that direct E. coli behaviour
Open accessAbstract
Previous efforts to control cellular behaviour have largely relied upon various forms of genetic engineering. Once the genetic content of a living cell is modified, the behaviour of that cell typically changes as well. However, other methods of cellular control are possible. All cells sense and respond to their environment. Therefore, artificial, non-living cellular mimics could be engineered to activate or repress already existing natural sensory pathways of living cells through chemical communication. Here we describe the construction of such a system. The artificial cells expand the senses of Escherichia coli by translating a chemical message that E. coli cannot sense on its own to a molecule that activates a natural cellular response. This methodology could open new opportunities in engineering cellular behaviour without exploiting genetically modified organisms.
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Kostka, J. E., Prakash, O., Overholt, W. A., Green, S. J., Freyer, G., Canion, A., Delgardio, J., Norton, N., Hazen, T. C., & Huettel, M. (2011) · Applied and Environmental Microbiology · doi:10.1128/aem.05402-11 · Cited by 875
d -Amino Acids Trigger Biofilm Disassembly
Kolodkin-Gal, I., Romero, D., Cao, S., Clardy, J., Kolter, R., & Losick, R. (2010) · Science · doi:10.1126/science.1188628 · Cited by 874
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van Roekel, H. W. H., Rosier, B. J. H. M., Meijer, L. H. H., Hilbers, P. A. J., Markvoort, A. J., Huck, W. T. S., & de Greef, T. F. A. (2015) · Chemical Society Reviews · doi:10.1039/c5cs00361j · Cited by 171
Metadata
- Authors
- Lentini, R., Santero, S. P., Chizzolini, F., Cecchi, D., Fontana, J., Marchioretto, M., Del Bianco, C., Terrell, J. L., Spencer, A. C., Martini, L., Forlin, M., Assfalg, M., Serra, M. D., Bentley, W. E., & Mansy, S. S.
- Venue
- Nature Communications
- Published
- 2014-05-30
- Volume
- 5
- Issue
- 1
- Pages
- 4012-4012
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2056289501
- Cited by
- 253
- References
- 2
- FWCI
- 9.93
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
