The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Primate evolution of the recombination regulator PRDM9
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Homology inference methods usually struggle to align genes with naturally low alignment scores due to their biological properties, such as fast-evolving genes like immunity genes or hybrid sterility genes (Trachana et al. 2011, Schwartz et al. 2014, Vinkler et al. 2023).”
From Annotation matters: the effect of structural gene annotation on orthology inference (2025) · cites this paper as Schwartz et al. 2014
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The complete genome sequence of a Neanderthal from the Altai Mountains
Prüfer, K., Racimo, F., Patterson, N., Jay, F., Sankararaman, S., Sawyer, S., Heinze, A., Renaud, G., Sudmant, P. H., de Filippo, C., et al. (2014) · Nature · doi:10.1038/nature12886 · Cited by 2,254
Self-citationA high-coverage genome sequence from an archaic denisovan individual
Meyer, M., Kircher, M., Gansauge, M.-T., Li, H., Racimo, F., Mallick, S., Schraiber, J. G., Jay, F., Prüfer, K., de Filippo, C., et al. (2012) · Science · doi:10.1126/science.1224344 · Cited by 1,967
Self-citationA histone H3 methyltransferase controls epigenetic events required for meiotic prophase
Hayashi, K., Yoshida, K., & Matsui, Y. (2005) · Nature · doi:10.1038/nature04112 · Cited by 472
Berg, I. L., Neumann, R., Lam, K.-W. G., Sarbajna, S., Odenthal-Hesse, L., May, C. A., & Jeffreys, A. J. (2010) · Nature Genetics · doi:10.1038/ng.658 · Cited by 315
Research works printed but not linked: 25
- Mihola, O., Trachtulec, Z., Vlcek, C., Schimenti, J. C. & Forejt, J. A mouse speciation gene encodes a meiotic histone H3 methyltransferase. Science 323, 373–375 (2009). · DOI
- Baudat, F. et al. PRDM9 is a major determinant of meiotic recombination hotspots in humans and mice. Science 327, 836–840 (2010). · DOI · Paper page
- Myers, S. et al. Drive against hotspot motifs in primates implicates the PRDM9 gene in meiotic recombination. Science 327, 876–879 (2010). · DOI · Paper page
- Parvanov, E. D., Petkov, P. M. & Paigen, K. Prdm9 controls activation of mammalian recombination hotspots. Science 327, 835 (2010). · DOI · Paper page
- Grey, C. et al. Mouse PRDM9 DNA-binding specificity determines sites of histone H3 lysine 4 trimethylation for initiation of meiotic recombination. PLoS Biol. 9, e1001176 (2011). · DOI
- Oliver, P. L. et al. Accelerated evolution of the Prdm9 speciation gene across diverse metazoan taxa. PLoS Genet. 5, e1000753 (2009). · DOI
- Irie, S. et al. Single-nucleotide polymorphisms of the PRDM9 (MEISETZ) gene in patients with nonobstructive azoospermia. J. Androl. 30, 426–431 (2009). · DOI
- Auton, A. et al. A fine-scale chimpanzee genetic map from population sequencing. Science 336, 193–198 (2012). · DOI
- Groeneveld, L. F., Atencia, R., Garriga, R. M. & Vigilant, L. High diversity at PRDM9 in chimpanzees and bonobos. PLoS ONE 7, e39064 (2012). · DOI
- Thomas, J. H., Emerson, R. O. & Shendure, J. Extraordinary molecular evolution in the PRDM9 fertility gene. PLoS ONE 4, e8505 (2009). · DOI
- Persikov, A. V., Osada, R. & Singh, M. Predicting DNA recognition by Cys2His2 zinc finger proteins. Bioinformatics 25, 22–29 (2009). · DOI
- Grant, C. E., Bailey, T. L. & Noble, W. S. FIMO: scanning for occurrences of a given motif. Bioinformatics 27, 1017–1018 (2011). · DOI · Paper page
- Rudd, M. K., Wray, G. A. & Willard, H. F. The evolutionary dynamics of alpha-satellite. Genome Res. 16, 88–96 (2006). · DOI
- Jeffreys, A. J., Cotton, V. E., Neumann, R. & Lam, K. W. Recombination regulator PRDM9 influences the instability of its own coding sequence in humans. Proc. Natl Acad. Sci. USA 110, 600–605 (2013). · DOI
- Ptak, S. E. et al. Fine-scale recombination patterns differ between chimpanzees and humans. Nat. Genet. 37, 429–434 (2005). · DOI
- Prado-Martinez, J. et al. Great ape genetic diversity and population history. Nature 499, 471–475 (2013). · DOI
- Botstein, D., White, R. L., Skolnick, M. & Davis, R. W. Construction of a genetic linkage map in man using restriction fragment length polymorphisms. Am. J. Hum. Genet. 32, 314–331 (1980).
- Nagy, S. et al. PICcalc: an online program to calculate polymorphic information content for molecular genetic studies. Biochem. Genet. 50, 670–672 (2012). · DOI
- Horton, R. et al. Gene map of the extended human MHC. Nat. Rev. Genet. 5, 889–899 (2004). · DOI
- Zuniga, J. et al. HLA class I and class II conserved extended haplotypes and their fragments or blocks in Mexicans: implications for the study of genetic diversity in admixed populations. PLoS ONE 8, e74442 (2013). · DOI
- Hach, F. et al. mrsFAST: a cache-oblivious algorithm for short-read mapping. Nat. Methods 7, 576–577 (2010). · DOI
- Sievers, F. & Higgins, D. G. Clustal Omega, accurate alignment of very large numbers of sequences. Methods Mol. Biol. 1079, 105–116 (2014). · DOI
- Yang, Z. PAML. 4: phylogenetic analysis by maximum likelihood. Mol. Biol. Evol. 24, 1586–1591 (2007). · DOI · Paper page
- Guindon, S. et al. New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0. Syst. Biol. 59, 307–321 (2010). · DOI · Paper page
- Bazinet, A. L., Zwickl, D. J. & Cummings, M. P. A gateway for phylogenetic analysis powered by grid computing featuring GARLI 2.0. Syst. Biol doi:10.1093/sysbio/syu031. · DOI
Cited by
Sorted by citations
Recombination rate evolution and the origin of species
Ortiz-Barrientos, D., Engelstädter, J., & Rieseberg, L. H. (2016) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2015.12.016 · Cited by 202
Strong, E., Butcher, D. T., Singhania, R., Mervis, C. B., Morris, C. A., De Carvalho, D., Weksberg, R., & Osborne, L. R. (2015) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2015.05.019 · Cited by 71
Multimer Formation Explains Allelic Suppression of PRDM9 Recombination Hotspots
Baker, C. L., Petkova, P., Walker, M., Flachs, P., Mihola, O., Trachtulec, Z., Petkov, P. M., & Paigen, K. (2015) · PLOS Genetics · doi:10.1371/journal.pgen.1005512 · Cited by 54
Annotation matters: the effect of structural gene annotation on orthology inference
Prieto-Baños, S., Nevers, Y., Altenhoff, A., Warwick Vesztrocy, A., Dessimoz, C., & Glover, N. M. (2025) · Bioinformatics · doi:10.1093/bioinformatics/btaf365 · Cited by 19
Metadata
- Authors
- Schwartz, J. J., Roach, D. J., Thomas, J. H., & Shendure, J.
- Venue
- Nature Communications
- Published
- 2014-07-08
- Volume
- 5
- Issue
- 1
- ISSN
- 2041-1723
- PMC
- PMC4110516
- Cited by
- 92
- References
- 4
- Language
- en
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
