The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
A graphene quantum dot photodynamic therapy agent with high singlet oxygen generation
Open accessAbstract
Clinical applications of current photodynamic therapy (PDT) agents are often limited by their low singlet oxygen (1O2) quantum yields, as well as by photobleaching and poor biocompatibility. Here we present a new PDT agent based on graphene quantum dots (GQDs) that can produce 1O2 via a multistate sensitization process, resulting in a quantum yield of ~1.3, the highest reported for PDT agents. The GQDs also exhibit a broad absorption band spanning the UV region and the entire visible region and a strong deep-red emission. Through in vitro and in vivo studies, we demonstrate that GQDs can be used as PDT agents, simultaneously allowing imaging and providing a highly efficient cancer therapy. The present work may lead to a new generation of carbon-based nanomaterial PDT agents with overall performance superior to conventional agents in terms of 1O2 quantum yield, water dispersibility, photo- and pH-stability, and biocompatibility. Photosensitisers are used in cancer therapy to promote the formation of reactive oxygen species on irradiation with light. Here, the authors present a graphene quantum dot photosensitiser with a singlet oxygen quantum yield of approximately 1.3, and investigate its in vitro and in vivoapplications
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Cites
Geim, A. K., & Novoselov, K. S. (2007) · Nature Materials · doi:10.1038/nmat1849 · Cited by 39,979
Graphene: Status and Prospects
Geim, A. K. (2009) · Science · doi:10.1126/science.1158877 · Cited by 13,942
Physical Mechanisms of Generation and Deactivation of Singlet Oxygen
Schweitzer, C., & Schmidt, R. (2003) · Chemical Reviews · doi:10.1021/cr010371d · Cited by 2,123
Cited by
Glowing Graphene Quantum Dots and Carbon Dots: Properties, Syntheses, and Biological Applications
Zheng, X. T., Ananthanarayanan, A., Luo, K. Q., & Chen, P. (2015) · Small · doi:10.1002/smll.201402648 · Cited by 2,190
Georgakilas, V., Perman, J. A., Tucek, J., & Zboril, R. (2015) · Chemical Reviews · doi:10.1021/cr500304f · Cited by 2,147
Self-targeting fluorescent carbon dots for diagnosis of brain cancer cells.
Zheng, M., Ruan, S., Liu, S., Sun, T., Qu, D., Zhao, H., Xie, Z., Gao, H., Jing, X., & Sun, Z. (2015) · ACS Nano · doi:10.1021/acsnano.5b05575 · Cited by 593
New Generation Cadmium-Free Quantum Dots for Biophotonics and Nanomedicine
Xu, G., Zeng, S., Zhang, B., Swihart, M. T., Yong, K.-T., & Prasad, P. N. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00290 · Cited by 587
Carbon-based nanomaterials as an emerging platform for theranostics
Patel, K. D., Singh, R. K., & Kim, H.-W. (2019) · Materials Horizons · doi:10.1039/c8mh00966j · Cited by 555
Metadata
- Authors
- Ge, J., Lan, M., Zhou, B., Liu, W., Guo, L., Wang, H., Jia, Q., Niu, G., Huang, X., Zhou, H., Meng, X., Wang, P., Lee, C.-S., Zhang, W., & Han, X.
- Venue
- Nature Communications
- Published
- 2014-08-08
- Volume
- 5
- Issue
- 1
- Pages
- 4596-4596
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2061824793
- Cited by
- 1,406
- References
- 3
- FWCI
- 43.03
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Ge, J., Lan, M., Zhou, B., Liu, W., Guo, L., Wang, H., Jia, Q., Niu, G., Huang, X., Zhou, H., Meng, X., Wang, P., Lee, C.-S., Zhang, W., & Han, X. (2014). A graphene quantum dot photodynamic therapy agent with high singlet oxygen generation. Nature Communications. https://doi.org/10.1038/ncomms5596
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