The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
A smart and versatile theranostic nanomedicine platform based on nanoporphyrin
Open accessAbstract
Multifunctional nanoparticles with combined diagnostic and therapeutic functions show great promise towards personalized nanomedicine. However, attaining consistently high performance of these functions in vivo in one single nanoconstruct remains extremely challenging. Here we demonstrate the use of one single polymer to develop a smart ‘all-in-one’ nanoporphyrin platform that conveniently integrates a broad range of clinically relevant functions. Nanoporphyrins can be used as amplifiable multimodality nanoprobes for near-infrared fluorescence imaging (NIRFI), magnetic resonance imaging (MRI), positron emission tomography (PET) and dual modal PET-MRI. Nanoporphyrins greatly increase the imaging sensitivity for tumour detection through background suppression in blood, as well as preferential accumulation and signal amplification in tumours. Nanoporphyrins also function as multiphase nanotransducers that can efficiently convert light to heat inside tumours for photothermal therapy (PTT), and light to singlet oxygen for photodynamic therapy (PDT). Furthermore, nanoporphyrins act as programmable releasing nanocarriers for targeted delivery of drugs or therapeutic radio-metals into tumours. Nanoparticles can be used for therapeutic and diagnostic purposes. Here, the authors report that nanoparticles made of a single chemical building block, called nanoporphyrins, incorporate eight different functionalities, including various types of imaging, drug delivery and cancer therapy.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Quantum Dots for Live Cells, in Vivo Imaging, and Diagnostics
Michalet, X., Pinaud, F. F., Bentolila, L. A., Tsay, J. M., Doose, S., Li, J. J., Sundaresan, G., Wu, A. M., Gambhir, S. S., & Weiss, S. (2005) · Science · doi:10.1126/science.1104274 · Cited by 7,790
Laurent, S., Forge, D., Port, M., Roch, A., Robic, C., Vander Elst, L., & Muller, R. N. (2008) · Chemical Reviews · doi:10.1021/cr068445e · Cited by 6,852
Photodynamic therapy of cancer: An update
Agostinis, P., Berg, K., Cengel, K. A., Foster, T. H., Girotti, A. W., Gollnick, S. O., Hahn, S. M., Hamblin, M. R., Juzeniene, A., Kessel, D., et al. (2011) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.20114 · Cited by 5,145
Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size
Cabral, H., Matsumoto, Y., Mizuno, K., Chen, Q., Murakami, M., Kimura, M., Terada, Y., Kano, M. R., Miyazono, K., Uesaka, M., et al. (2011) · Nature Nanotechnology · doi:10.1038/nnano.2011.166 · Cited by 2,429
Mahmoudi, M., Sant, S., Wang, B., Laurent, S., & Sen, T. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2010.05.006 · Cited by 1,881
Photo-thermal tumor ablation in mice using near infrared-absorbing nanoparticles
O'Neal, D. P., Hirsch, L. R., Halas, N. J., Payne, J. D., & West, J. L. (2004) · Cancer Letters · doi:10.1016/j.canlet.2004.02.004 · Cited by 1,849
In vivo photodynamic therapy using upconversion nanoparticles as remote-controlled nanotransducers
Idris, N. M., Gnanasammandhan, M. K., Zhang, J., Ho, P. C., Mahendran, R., & Zhang, Y. (2012) · Nature Medicine · doi:10.1038/nm.2933 · Cited by 1,464
Nanoparticle-based theranostic agents
Xie, J., Lee, S., & Chen, X. (2010) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2010.07.009 · Cited by 1,422
Multifunctional nanoparticles for multimodal imaging and theragnosis
Lee, D.-E., Koo, H., Sun, I.-C., Ryu, J. H., Kim, K., & Kwon, I. C. (2012) · Chem. Soc. Rev. · doi:10.1039/c2cs15261d · Cited by 1,410
Lovell, J. F., Jin, C. S., Huynh, E., Jin, H., Kim, C., Rubinstein, J. L., Chan, W. C. W., Cao, W., Wang, L. V., & Zheng, G. (2011) · Nature Materials · doi:10.1038/nmat2986 · Cited by 1,362
Multifunctional Nanoparticles: Cost Versus Benefit of Adding Targeting and Imaging Capabilities
Cheng, Z., Al Zaki, A., Hui, J. Z., Muzykantov, V. R., & Tsourkas, A. (2012) · Science · doi:10.1126/science.1226338 · Cited by 1,322
Potential toxicity of superparamagnetic iron oxide nanoparticles (SPION)
Singh, N., Jenkins, G. J. S., Asadi, R., & Doak, S. H. (2010) · Nano Reviews · doi:10.3402/nano.v1i0.5358 · Cited by 1,112
Chauhan, V. P., Stylianopoulos, T., Martin, J. D., Popović, Z., Chen, O., Kamoun, W. S., Bawendi, M. G., Fukumura, D., & Jain, R. K. (2012) · Nature Nanotechnology · doi:10.1038/nnano.2012.45 · Cited by 1,101
Photothermally Enhanced Photodynamic Therapy Delivered by Nano-Graphene Oxide
Tian, B., Wang, C., Zhang, S., Feng, L., & Liu, Z. (2011) · ACS Nano · doi:10.1021/nn201560b · Cited by 1,079
Computationally Guided Photothermal Tumor Therapy Using Long-Circulating Gold Nanorod Antennas
von Maltzahn, G., Park, J.-H., Agrawal, A., Bandaru, N. K., Das, S. K., Sailor, M. J., & Bhatia, S. N. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-4242 · Cited by 1,051
Xiao, K., Li, Y., Luo, J., Lee, J. S., Xiao, W., Gonik, A. M., Agarwal, R. G., & Lam, K. S. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.01.021 · Cited by 1,039
Self-citationSimultaneous PET-MRI: a new approach for functional and morphological imaging
Judenhofer, M. S., Wehrl, H. F., Newport, D. F., Catana, C., Siegel, S. B., Becker, M., Thielscher, A., Kneilling, M., Lichy, M. P., Eichner, M., et al. (2008) · Nature Medicine · doi:10.1038/nm1700 · Cited by 981
Self-citationTheranostic Nanoshells: From Probe Design to Imaging and Treatment of Cancer
Bardhan, R., Lal, S., Joshi, A., & Halas, N. J. (2011) · Accounts of Chemical Research · doi:10.1021/ar200023x · Cited by 917
Jang, B., Park, J.-Y., Tung, C.-H., Kim, I.-H., & Choi, Y. (2011) · ACS Nano · doi:10.1021/nn102722z · Cited by 750
Lee, H.-Y., Li, Z., Chen, K., Hsu, A. R., Xu, C., Xie, J., Sun, S., & Chen, X. (2008) · Journal of Nuclear Medicine · doi:10.2967/jnumed.108.051243 · Cited by 557
Choi, K. Y., Liu, G., Lee, S., & Chen, X. (2012) · Nanoscale · doi:10.1039/c1nr11277e · Cited by 437
Cheng, L., Yang, K., Chen, Q., & Liu, Z. (2012) · ACS Nano · doi:10.1021/nn301539m · Cited by 429
Jin, C. S., Lovell, J. F., Chen, J., & Zheng, G. (2013) · ACS Nano · doi:10.1021/nn3058642 · Cited by 414
Koo, A. N., Lee, H. J., Kim, S. E., Chang, J. H., Park, C., Kim, C., Park, J. H., & Lee, S. C. (2008) · Chemical Communications · doi:10.1039/b815918a · Cited by 395
Li, Y., Xiao, W., Xiao, K., Berti, L., Luo, J., Tseng, H. P., Fung, G., & Lam, K. S. (2012) · Angewandte Chemie International Edition · doi:10.1002/anie.201107144 · Cited by 360
Self-citationWang, J., Zhu, G., You, M., Song, E., Shukoor, M. I., Zhang, K., Altman, M. B., Chen, Y., Zhu, Z., Huang, C. Z., et al. (2012) · ACS Nano · doi:10.1021/nn300694v · Cited by 357
Zhou, K., Liu, H., Zhang, S., Huang, X., Wang, Y., Huang, G., Sumer, B. D., & Gao, J. (2012) · Journal of the American Chemical Society · doi:10.1021/ja300176w · Cited by 344
Matsumoto, S., Christie, R. J., Nishiyama, N., Miyata, K., Ishii, A., Oba, M., Koyama, H., Yamasaki, Y., & Kataoka, K. (2009) · Biomacromolecules · doi:10.1021/bm800985e · Cited by 327
Well-defined, reversible disulfide cross-linked micelles for on-demand paclitaxel delivery
Li, Y., Xiao, K., Luo, J., Xiao, W., Lee, J. S., Gonik, A. M., Kato, J., Dong, T. A., & Lam, K. S. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.05.050 · Cited by 312
Self-citationKuo, W.-S., Chang, Y.-T., Cho, K.-C., Chiu, K.-C., Lien, C.-H., Yeh, C.-S., & Chen, S.-J. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.01.035 · Cited by 305
Simultaneous in vivo positron emission tomography and magnetic resonance imaging
Catana, C., Procissi, D., Wu, Y., Judenhofer, M. S., Qi, J., Pichler, B. J., Jacobs, R. E., & Cherry, S. R. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711622105 · Cited by 272
Self-citationChoi, J., Park, J. C., Nah, H., Woo, S., Oh, J., Kim, K. M., Cheon, G. J., Chang, Y., Yoo, J., & Cheon, J. (2008) · Angewandte Chemie International Edition · doi:10.1002/anie.200801369 · Cited by 222
Emerging application of quantum dots for drug delivery and therapy
Qi, L., & Gao, X. (2008) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.5.3.263 · Cited by 220
Photosensitizer Loaded Nano-Graphene for Multimodality Imaging Guided Tumor Photodynamic Therapy
Rong, P., Yang, K., Srivastan, A., Kiesewetter, D. O., Yue, X., Wang, F., Nie, L., Bhirde, A., Wang, Z., Liu, Z., et al. (2014) · Theranostics · doi:10.7150/thno.8070 · Cited by 218
Chen, X., Gambhir, S. S., & Cheon, J. (2011) · Accounts of Chemical Research · doi:10.1021/ar200231d · Cited by 183
Torres Martin de Rosales, R., Tavaré, R., Paul, R. L., Jauregui‐Osoro, M., Protti, A., Glaria, A., Varma, G., Szanda, I., & Blower, P. J. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201007894 · Cited by 181
Yang, H., Mao, H., Wan, Z., Zhu, A., Guo, M., Li, Y., Li, X., Wan, J., Yang, X., Shuai, X., et al. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.08.022 · Cited by 159
Self-citationLuo, J., Xiao, K., Li, Y., Lee, J. S., Shi, L., Tan, Y.-H., Li, X., Cheng, R. H., Liu, G.-Y., & Lam, K. S. (2010) · Bioconjugate Chemistry · doi:10.1021/bc1000033 · Cited by 151
Self-citationLipid- and Polymer-Based Nanostructures for Cancer Theranostics
Luk, B. T., Fang, R. H., & Zhang, L. (2012) · Theranostics · doi:10.7150/thno.4381 · Cited by 148
Yang, Z., Zheng, S., Harrison, W. J., Harder, J., Wen, X., Gelovani, J. G., Qiao, A., & Li, C. (2007) · Biomacromolecules · doi:10.1021/bm7005399 · Cited by 130
Ng, K. K., Lovell, J. F., Vedadi, A., Hajian, T., & Zheng, G. (2013) · ACS Nano · doi:10.1021/nn400418y · Cited by 127
A novel size-tunable nanocarrier system for targeted anticancer drug delivery
Li, Y., Xiao, K., Luo, J., Lee, J., Pan, S., & Lam, K. S. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.02.027 · Cited by 125
Self-citationXiao, K., Luo, J., Li, Y., Lee, J. S., Fung, G., & Lam, K. S. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.07.018 · Cited by 110
Self-citationLi, Y., Budamagunta, M. S., Luo, J., Xiao, W., Voss, J. C., & Lam, K. S. (2012) · ACS Nano · doi:10.1021/nn302317j · Cited by 105
Self-citationNanoparticle-Based Systems for T1-Weighted Magnetic Resonance Imaging Contrast Agents
Zhu, D., Liu, F., Ma, L., Liu, D., & Wang, Z. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140510591 · Cited by 103
Xiao, K., Li, Y., Lee, J. S., Gonik, A. M., Dong, T., Fung, G., Sanchez, E., Li, X., Cheng, H. R., Luo, J., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-3883 · Cited by 94
Self-citationPhotothermally enhanced photodynamic therapy based on mesoporous Pd@Ag@mSiO2 nanocarriers
Shi, S., Zhu, X., Zhao, Z., Fang, W., Chen, M., Huang, Y., & Chen, X. (2012) · Journal of Materials Chemistry B · doi:10.1039/c2tb00376g · Cited by 65
Novel Gd Nanoparticles Enhance Vascular Contrast for High-Resolution Magnetic Resonance Imaging
Bui, T., Stevenson, J., Hoekman, J., Zhang, S., Maravilla, K. R., & Ho, R. J. Y. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013082 · Cited by 57
Disulfide Cross-Linked Micelles for the Targeted Delivery of Vincristine to B-Cell Lymphoma
Kato, J., Li, Y., Xiao, K., et al. (2012) · Molecular Pharmaceutics · doi:10.1021/mp300128b · Cited by 52
Self-citationPorphyrin and Galactosyl Conjugated Micelles for Targeting Photodynamic Therapy
Wu, D., Li, Z., Li, C., Fan, J., Lu, B., Chang, C., Cheng, S., Zhang, X., & Zhuo, R. (2009) · Pharmaceutical Research · doi:10.1007/s11095-009-9998-8 · Cited by 52
Theranostic Nanomedicine with Functional Nanoarchitecture
Pan, D. (2013) · Molecular Pharmaceutics · doi:10.1021/mp400044j · Cited by 49
Cited by
Nanochemistry and Nanomedicine for Nanoparticle-based Diagnostics and Therapy
Chen, G., Roy, I., Yang, C., & Prasad, P. N. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00148 · Cited by 1,499
Nanomaterials for In Vivo Imaging
Smith, B. R., & Gambhir, S. S. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00073 · Cited by 1,075
Oncologic Photodynamic Therapy: Basic Principles, Current Clinical Status and Future Directions
Van Straten, D., Mashayekhi, V., De Bruijn, H., Oliveira, S., & Robinson, D. (2017) · Cancers · doi:10.3390/cancers9020019 · Cited by 1,012
Polymer–drug conjugate therapeutics: advances, insights and prospects
Ekladious, I., Colson, Y. L., & Grinstaff, M. W. (2019) · Nature Reviews Drug Discovery · doi:10.1038/s41573-018-0005-0 · Cited by 855
Espinosa, A., Di Corato, R., Kolosnjaj-Tabi, J., Flaud, P., Pellegrino, T., & Wilhelm, C. (2016) · ACS Nano · doi:10.1021/acsnano.5b07249 · Cited by 788
Metadata
- Authors
- Li, Y., Lin, T.-Y., Luo, Y., Liu, Q., Xiao, W., Guo, W., Lac, D., Zhang, H., Feng, C., Wachsmann-Hogiu, S., Walton, J. H., Cherry, S. R., Rowland, D. J., Kukis, D., Pan, C., & Lam, K. S.
- Venue
- Nature Communications
- Published
- 2014-08-26
- Volume
- 5
- Issue
- 1
- Pages
- 4712-4712
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W1999313400
- Cited by
- 414
- References
- 51
- FWCI
- 22.68
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
